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    Zfp579 zinc finger protein 579 [ Mus musculus (house mouse) ]

    Gene ID: 68490, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfp579provided by MGI
    Official Full Name
    zinc finger protein 579provided by MGI
    Primary source
    MGI:MGI:1915740
    See related
    Ensembl:ENSMUSG00000051550 AllianceGenome:MGI:1915740
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Znf579; 1110003A17Rik
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and transcription cis-regulatory region binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in metencephalon part of 4th ventricle choroid plexus. Orthologous to human ZNF579 (zinc finger protein 579). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 40.0), whole brain E14.5 (RPKM 32.1) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp579 in Genome Data Viewer
    Location:
    7 A1; 7 2.88 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (4995851..4999100, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (4992852..4996101, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene SH3-binding domain kinase family, member 2 Neighboring gene SH3 domain binding kinase family, member 3 Neighboring gene predicted gene, 53351 Neighboring gene Flt3 interacting zinc finger protein 1 Neighboring gene STARR-seq mESC enhancer starr_17950

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    2. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription cis-regulatory region binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription cis-regulatory region binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 579

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026741.2 → NP_081017.1  zinc finger protein 579

      See identical proteins and their annotated locations for NP_081017.1

      Status: VALIDATED

      Source sequence(s)
      BC048385, CX205499
      Consensus CDS
      CCDS39744.1
      UniProtKB/Swiss-Prot
      Q80VM4
      Related
      ENSMUSP00000104212.2, ENSMUST00000108572.2
      Conserved Domains (4) summary
      COG5048
      Location:45 → 107
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:384 → 404
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:295 → 317
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:60 → 85
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      4995851..4999100 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006540335.4 → XP_006540398.1  zinc finger protein 579 isoform X1

      See identical proteins and their annotated locations for XP_006540398.1

      UniProtKB/Swiss-Prot
      Q80VM4
      Conserved Domains (4) summary
      COG5048
      Location:45 → 107
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:384 → 404
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:295 → 317
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:60 → 85
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80VM4.1 GenPept UniProtKB/Swiss-Prot:Q80VM4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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