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    Hhatl hedgehog acyltransferase-like [ Mus musculus (house mouse) ]

    Gene ID: 74770, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hhatlprovided by MGI
    Official Full Name
    hedgehog acyltransferase-likeprovided by MGI
    Primary source
    MGI:MGI:1922020
    See related
    Ensembl:ENSMUSG00000032523 AllianceGenome:MGI:1922020
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gup1; Mg56; 1110011D13Rik
    Summary
    Involved in negative regulation of N-terminal protein palmitoylation. Located in endoplasmic reticulum. Orthologous to human HHATL (hedgehog acyltransferase like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in heart adult (RPKM 20.6), mammary gland adult (RPKM 4.7) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Hhatl in Genome Data Viewer
    Location:
    9 F4; 9 72.62 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (121613082..121626604, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (121784016..121792507, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA E530011L22 gene Neighboring gene STARR-positive B cell enhancer ABC_E6812 Neighboring gene zinc finger and BTB domain containing 47 Neighboring gene kelch-like 40 Neighboring gene coiled-coil domain containing 13 Neighboring gene predicted gene, 51698 Neighboring gene STARR-positive B cell enhancer ABC_E3869 Neighboring gene HIG1 domain family, member 1A Neighboring gene predicted gene, 47112

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mitsugumin 56 (hedgehog acyltransferase-like) is a sarcoplasmic reticulum-resident protein essential for postnatal muscle maturation. Van B, et al. FEBS Lett, 2015 Apr 28. PMID 25841338
    2. Mammalian Gup1, a homolog of Saccharomyces cerevisiae glycerol uptake/transporter 1, acts as a negative regulator for N-terminal palmitoylation of Sonic hedgehog. Abe Y, et al. FEBS J, 2008 Jan. PMID 18081866
    3. Isolation of novel heart-specific genes using the BodyMap database. Soejima H, et al. Genomics, 2001 May 15. PMID 11374908
    4. Genesis of muscle fiber-type diversity during mouse embryogenesis relies on Six1 and Six4 gene expression. Richard AF, et al. Dev Biol, 2011 Nov 15. PMID 21884692
    5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MG56 seems essential for postnatal skeletal muscle maturation
      Title: Mitsugumin 56 (hedgehog acyltransferase-like) is a sarcoplasmic reticulum-resident protein essential for postnatal muscle maturation.
    2. results suggest that Gup1 is a negative regulator of N-terminal palmitoylation of Shh and may contribute to the variety of biological actions of Shh
      Title: Mammalian Gup1, a homolog of Saccharomyces cerevisiae glycerol uptake/transporter 1, acts as a negative regulator for N-terminal palmitoylation of Sonic hedgehog.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (1)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of N-terminal protein palmitoylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein-cysteine N-palmitoyltransferase HHAT-like protein
    Names
    Mitsugumin 56
    glycerol uptake/transporter homolog
    hedgehog acyltransferase-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029095.2 → NP_083371.2  protein-cysteine N-palmitoyltransferase HHAT-like protein

      See identical proteins and their annotated locations for NP_083371.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein.
      Source sequence(s)
      AC165080, AK003605, BY232310, BY290483, BY703867
      Consensus CDS
      CCDS23638.1
      UniProtKB/Swiss-Prot
      Q3TZE3, Q8R1K3, Q9D1G3
      Related
      ENSMUSP00000035110.5, ENSMUST00000035110.11
      Conserved Domains (1) summary
      cl00738
      Location:139 → 449
      MBOAT; membrane-bound O-acyltransferase family

    RNA

    1. NR_027967.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate 5' exon, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC165080, AK157924

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      121613082..121626604 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155362.1 → XP_036011255.1  protein-cysteine N-palmitoyltransferase HHAT-like protein isoform X2

      Conserved Domains (1) summary
      cl00738
      Location:86 → 235
      MBOAT; membrane-bound O-acyltransferase family

    2. XM_030244689.2 → XP_030100549.1  protein-cysteine N-palmitoyltransferase HHAT-like protein isoform X1

      UniProtKB/Swiss-Prot
      Q3TZE3, Q8R1K3, Q9D1G3
      Conserved Domains (1) summary
      cl00738
      Location:139 → 449
      MBOAT; membrane-bound O-acyltransferase family

    3. XM_006512380.5 → XP_006512443.1  protein-cysteine N-palmitoyltransferase HHAT-like protein isoform X1

      See identical proteins and their annotated locations for XP_006512443.1

      UniProtKB/Swiss-Prot
      Q3TZE3, Q8R1K3, Q9D1G3
      Conserved Domains (1) summary
      cl00738
      Location:139 → 449
      MBOAT; membrane-bound O-acyltransferase family

    4. XM_006512379.4 → XP_006512442.1  protein-cysteine N-palmitoyltransferase HHAT-like protein isoform X1

      See identical proteins and their annotated locations for XP_006512442.1

      UniProtKB/Swiss-Prot
      Q3TZE3, Q8R1K3, Q9D1G3
      Conserved Domains (1) summary
      cl00738
      Location:139 → 449
      MBOAT; membrane-bound O-acyltransferase family

    5. XM_006512381.4 → XP_006512444.1  protein-cysteine N-palmitoyltransferase HHAT-like protein isoform X1

      See identical proteins and their annotated locations for XP_006512444.1

      UniProtKB/Swiss-Prot
      Q3TZE3, Q8R1K3, Q9D1G3
      Related
      ENSMUSP00000131971.2, ENSMUST00000163981.3
      Conserved Domains (1) summary
      cl00738
      Location:139 → 449
      MBOAT; membrane-bound O-acyltransferase family

    6. XM_011243053.2 → XP_011241355.1  protein-cysteine N-palmitoyltransferase HHAT-like protein isoform X2

      Conserved Domains (1) summary
      cl00738
      Location:86 → 235
      MBOAT; membrane-bound O-acyltransferase family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D1G3.2 GenPept UniProtKB/Swiss-Prot:Q9D1G3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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