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    Siglec15 sialic acid binding Ig-like lectin 15 [ Mus musculus (house mouse) ]

    Gene ID: 620235, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Siglec15provided by MGI
    Official Full Name
    sialic acid binding Ig-like lectin 15provided by MGI
    Primary source
    MGI:MGI:3646642
    See related
    Ensembl:ENSMUSG00000091055 AllianceGenome:MGI:3646642
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cd33l3; EG620235; SIGLEC-I
    Summary
    Acts upstream of or within regulation of actin cytoskeleton organization; regulation of bone resorption; and regulation of osteoclast development. Located in plasma membrane. Part of protein-containing complex. Is expressed in eye; immune system; reproductive system; and stomach. Orthologous to human SIGLEC15 (sialic acid binding Ig like lectin 15). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in ovary adult (RPKM 17.6) and thymus adult (RPKM 2.6) See more
    Orthologs
    human all
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    Genomic context

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    See Siglec15 in Genome Data Viewer
    Location:
    18 E3; 18 52.43 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (78085708..78100656, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (78042493..78057441, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA F830208F22 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:78061325-78061621 Neighboring gene proline-serine-threonine phosphatase-interacting protein 2 Neighboring gene STARR-positive B cell enhancer ABC_E2514 Neighboring gene ectopic P-granules 5 autophagy tethering factor Neighboring gene STARR-seq mESC enhancer starr_45139 Neighboring gene solute carrier family 14 (urea transporter), member 1 Neighboring gene predicted gene, 36338 Neighboring gene solute carrier family 14 (urea transporter), member 2 Neighboring gene STARR-positive B cell enhancer mm9_chr18:78408899-78409200 Neighboring gene STARR-seq mESC enhancer starr_45142 Neighboring gene predicted gene, 54027

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Osteoclast-derived apoptotic bodies inhibit naive CD8(+) T cell activation via Siglec15, promoting breast cancer secondary metastasis. Wu Y, et al. Cell Rep Med, 2023 Sep 19. PMID 37607544, Free PMC Article
    2. Siglec-15, a member of the sialic acid-binding lectin, is a novel regulator for osteoclast differentiation. Hiruma Y, et al. Biochem Biophys Res Commun, 2011 Jun 10. PMID 21586272
    3. Impaired osteoclast differentiation and function and mild osteopetrosis development in Siglec-15-deficient mice. Hiruma Y, et al. Bone, 2013 Mar. PMID 23238125
    4. Siglec-15 is a potential therapeutic target for postmenopausal osteoporosis. Kameda Y, et al. Bone, 2015 Feb. PMID 25460183
    5. Sialic acid-binding immunoglobulin-like lectin 15 (Siglec-15) mediates periarticular bone loss, but not joint destruction, in murine antigen-induced arthritis. Shimizu T, et al. Bone, 2015 Oct. PMID 26027508

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Involvement of Siglec-15 in regulating RAP1/RAC signaling in cytoskeletal remodeling in osteoclasts mediated by macrophage colony-stimulating factor.
      Title: Involvement of Siglec-15 in regulating RAP1/RAC signaling in cytoskeletal remodeling in osteoclasts mediated by macrophage colony-stimulating factor.
    2. Osteoclast-derived apoptotic bodies inhibit naive CD8[+] T cell activation via Siglec15, promoting breast cancer secondary metastasis.
      Title: Osteoclast-derived apoptotic bodies inhibit naive CD8(+) T cell activation via Siglec15, promoting breast cancer secondary metastasis.
    3. Siglec-15 Promotes Evasion of Adaptive Immunity in B-cell Acute Lymphoblastic Leukemia.
      Title: Siglec-15 Promotes Evasion of Adaptive Immunity in B-cell Acute Lymphoblastic Leukemia.
    4. Dynamic change in Siglec-15 expression in peritumoral macrophages confers an immunosuppressive microenvironment and poor outcome in glioma.
      Title: Dynamic change in Siglec-15 expression in peritumoral macrophages confers an immunosuppressive microenvironment and poor outcome in glioma.
    5. [Study on the effect and mechanisms of SIGLEC-15 on laryngeal squamous cell carcinoma].
      Title: [Study on the effect and mechanisms of SIGLEC-15 on laryngeal squamous cell carcinoma].
    6. Molecular structure, expression, and the emerging role of Siglec-15 in skeletal biology and cancer.
      Title: Molecular structure, expression, and the emerging role of Siglec-15 in skeletal biology and cancer.
    7. Siglec-15 on Osteoclasts Is Crucial for Bone Erosion in Serum-Transfer Arthritis.
      Title: Siglec-15 on Osteoclasts Is Crucial for Bone Erosion in Serum-Transfer Arthritis.
    8. Siglec-15 is a potential target for normalization cancer immunotherapy.
      Title: Siglec-15 as an immune suppressor and potential target for normalization cancer immunotherapy.
    9. Siglec-15 does not mediate joint destruction in inflammatory arthritis
      Title: Sialic acid-binding immunoglobulin-like lectin 15 (Siglec-15) mediates periarticular bone loss, but not joint destruction, in murine antigen-induced arthritis.
    10. The present findings indicate that Siglec-15 is involved in estrogen deficiency-induced differentiation of osteoclasts and is thus a potential therapeutic target for postmenopausal osteoporosis.
      Title: Siglec-15 is a potential therapeutic target for postmenopausal osteoporosis.
    Submit: New GeneRIF Correction See all GeneRIFs (15)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (9) 
    • Targeted (3)  1 citation

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of bone resorption IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of bone resorption IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of osteoclast development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of osteoclast development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of osteoclast development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sialic acid-binding Ig-like lectin 15
    Names
    CD33 molecule-like 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001101038.2 → NP_001094508.1  sialic acid-binding Ig-like lectin 15 precursor

      See identical proteins and their annotated locations for NP_001094508.1

      Status: VALIDATED

      Source sequence(s)
      AC126553
      Consensus CDS
      CCDS50329.1
      UniProtKB/TrEMBL
      A7E1W8
      Related
      ENSMUSP00000126901.3, ENSMUST00000170760.3
      Conserved Domains (4) summary
      cd00096
      Location:188 → 250
      Ig; Immunoglobulin domain
      smart00410
      Location:49 → 164
      IG_like; Immunoglobulin like
      pfam07679
      Location:169 → 251
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:44 → 149
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      78085708..78100656 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030250561.1 → XP_030106421.1  sialic acid-binding Ig-like lectin 15 isoform X1

      Conserved Domains (2) summary
      cd00096
      Location:187 → 249
      Ig; Immunoglobulin domain
      cl11960
      Location:44 → 149
      Ig; Immunoglobulin domain

    2. XM_036161229.1 → XP_036017122.1  sialic acid-binding Ig-like lectin 15 isoform X3

      Conserved Domains (2) summary
      cd00096
      Location:6 → 10
      Ig; Ig strand A' [structural motif]
      cl11960
      Location:2 → 100
      Ig; Immunoglobulin domain

    3. XM_011247091.3 → XP_011245393.1  sialic acid-binding Ig-like lectin 15 isoform X2

      Conserved Domains (2) summary
      cd00096
      Location:188 → 250
      Ig; Immunoglobulin domain
      cl11960
      Location:44 → 149
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version

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