Slc41a1 solute carrier family 41, member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc41a1provided by MGI
Official Full Name: solute carrier family 41, member 1provided by MGI
Primary source: MGI:MGI:2444823
See related: Ensembl:ENSMUSG00000013275 AllianceGenome:MGI:2444823
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: B230315F01Rik
Summary: Enables inorganic cation transmembrane transporter activity. Involved in cellular response to magnesium ion and magnesium ion transmembrane transport. Predicted to be located in basolateral plasma membrane. Predicted to be part of protein-containing complex. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; mesenteric adipose tissue; and respiratory system. Human ortholog(s) of this gene implicated in nephronophthisis. Orthologous to human SLC41A1 (solute carrier family 41 member 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in ovary adult (RPKM 28.8), heart adult (RPKM 25.2) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 E4; 1 57.2 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (131755236..131776601)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (131828012..131848863)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SLC41A1 knockout mice display normal magnesium homeostasis.
Title: SLC41A1 knockout mice display normal magnesium homeostasis.
Magnesium Homeostasis in Myogenic Differentiation-A Focus on the Regulation of TRPM7, MagT1 and SLC41A1 Transporters.
Title: Magnesium Homeostasis in Myogenic Differentiation-A Focus on the Regulation of TRPM7, MagT1 and SLC41A1 Transporters.
Dietary Mg(2+) Intake and the Na(+)/Mg(2+) Exchanger SLC41A1 Influence Components of Mitochondrial Energetics in Murine Cardiomyocytes.
Title: Dietary Mg(2+) Intake and the Na(+)/Mg(2+) Exchanger SLC41A1 Influence Components of Mitochondrial Energetics in Murine Cardiomyocytes.
Knockdown of SLC41A1 magnesium transporter promotes mineralization and attenuates magnesium inhibition during osteogenesis of mesenchymal stromal cells.
Title: Knockdown of SLC41A1 magnesium transporter promotes mineralization and attenuates magnesium inhibition during osteogenesis of mesenchymal stromal cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI573938 (e-PCR)
- UniSTS:164127

Slc41a1 (e-PCR), detects polymorphism
- UniSTS:547111

RH129649 (e-PCR)
- UniSTS:212946

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables inorganic cation transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables magnesium ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables magnesium:sodium antiporter activity	ISO Inferred from Sequence Orthology more info
enables magnesium:sodium antiporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to magnesium ion	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to magnesium ion	ISO Inferred from Sequence Orthology more info
involved_in intracellular magnesium ion homeostasis	IEA Inferred from Electronic Annotation more info
involved_in intracellular magnesium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in magnesium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in magnesium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in magnesium ion transport	ISO Inferred from Sequence Orthology more info
involved_in metal ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in sodium ion transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: solute carrier family 41 member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_173865.3 → NP_776290.1 solute carrier family 41 member 1

See identical proteins and their annotated locations for NP_776290.1

Status: VALIDATED

Source sequence(s)

AC161805, BC037033, BC116280

Consensus CDS

CCDS15275.1

UniProtKB/Swiss-Prot

Q8BJA2

Related

ENSMUSP00000083747.7, ENSMUST00000086559.7

Conserved Domains (1) summary

pfam01769
Location:138 → 269

MgtE; Divalent cation transporter

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

131755236..131776601

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036154630.1 → XP_036010523.1 solute carrier family 41 member 1 isoform X1

UniProtKB/Swiss-Prot

Q8BJA2

Conserved Domains (1) summary

pfam01769
Location:138 → 269

MgtE; Divalent cation transporter
XM_036154631.1 → XP_036010524.1 solute carrier family 41 member 1 isoform X1

UniProtKB/Swiss-Prot

Q8BJA2

Conserved Domains (1) summary

pfam01769
Location:138 → 269

MgtE; Divalent cation transporter