Parp3 poly (ADP-ribose) polymerase family, member 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Parp3provided by MGI
Official Full Name: poly (ADP-ribose) polymerase family, member 3provided by MGI
Primary source: MGI:MGI:1891258
See related: Ensembl:ENSMUSG00000023249 AllianceGenome:MGI:1891258
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ARTD3; Adprt3; PARP-3; ADPRT-3; Adprtl3; pADPRT-3; A930002C11Rik
Summary: Predicted to enable NAD DNA ADP-ribosyltransferase activity and NAD+-protein ADP-ribosyltransferase activity. Involved in negative regulation of isotype switching. Acts upstream of or within double-strand break repair. Located in site of double-strand break. Is expressed in primordial germ cell of gonad. Orthologous to human PARP3 (poly(ADP-ribose) polymerase family member 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in subcutaneous fat pad adult (RPKM 25.0), bladder adult (RPKM 19.6) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 F1; 9 57.58 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (106347521..106354148, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (106470322..106476949, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Fall of PARP3 restrains Lgr5[+] intestinal stem cells proliferation and mucosal renovation in intestinal aging.
Title: Fall of PARP3 restrains Lgr5(+) intestinal stem cells proliferation and mucosal renovation in intestinal aging.
these data indicate that Parp3 and Parp1 promote rearrangements with distinct phenotypes.
Title: Parp3 promotes long-range end joining in murine cells.
We show that Poly(ADP)ribose polymerase 3 (Parp3), an enzyme recently implicated in DNA repair, contributes to antibody diversification by negatively regulating class switch recombination without affecting somatic hypermutation.
Title: Parp3 negatively regulates immunoglobulin class switch recombination.
PARP-3 has a role in chromosomal DNA double-strand break repair.
Title: PARP-3 and APLF function together to accelerate nonhomologous end-joining.
We cloned and sequenced the cDNAs of the mouse PARP-3 (Adprt3) gene encoding poly(ADP-ribose) polymerase 3 and of the closely linked U3-55k gene coding for the U3 small nucleolar ribonucleoprotein complex-associated 55-kilodalton protein.
Title: Cloning and expression of PARP-3 (Adprt3) and U3-55k, two genes closely linked on mouse chromosome 9.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1) 1 citation
Targeted (2) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables NAD DNA ADP-ribosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables NAD DNA ADP-ribosyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables NAD+-protein ADP-ribosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables NAD+-protein ADP-ribosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables NAD+-protein poly-ADP-ribosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables NAD+-protein poly-ADP-ribosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables NAD+-protein-aspartate ADP-ribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables NAD+-protein-aspartate ADP-ribosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables NAD+-protein-glutamate ADP-ribosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables NAD+-protein-lysine ADP-ribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables NAD+-protein-lysine ADP-ribosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables nucleotidyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA ADP-ribosylation	ISO Inferred from Sequence Orthology more info
involved_in DNA ADP-ribosylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in double-strand break repair	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within double-strand break repair	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within double-strand break repair	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of isotype switching	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of DNA ligation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of double-strand break repair via nonhomologous end joining	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of double-strand break repair via nonhomologous end joining	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein auto-ADP-ribosylation	IEA Inferred from Electronic Annotation more info
involved_in protein auto-ADP-ribosylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization to site of double-strand break	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of mitotic spindle organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within telomere maintenance	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in centriole	IEA Inferred from Electronic Annotation more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in intercellular bridge	IEA Inferred from Electronic Annotation more info
located_in intercellular bridge	ISO Inferred from Sequence Orthology more info
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in site of double-strand break	IBA Inferred from Biological aspect of Ancestor more info
located_in site of double-strand break	IDA Inferred from Direct Assay more info	PubMed
located_in site of double-strand break	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein mono-ADP-ribosyltransferase PARP3

Names: A DP-ribosyltransferase (NAD+; poly (ADP-ribose polymerase)-like 3; ADP-ribosyltransferase (NAD+, poly (ADP-ribose polymerase)-like 3; ADP-ribosyltransferase diphtheria toxin-like 3; DNA ADP-ribosyltransferase PARP3; NAD(+) ADP-ribosyltransferase 3; NAD+ ADP-ribosyltransferase 3; Poly[ADP-ribose] synthetase-3; poly [ADP-ribose] polymerase 3; poly[ADP-ribose] synthase 3

NP_001298079.1

EC 2.4.2.30

NP_663594.2

EC 2.4.2.30

XP_006511781.1

EC 2.4.2.30

XP_006511782.1

EC 2.4.2.30

XP_006511783.1

EC 2.4.2.30

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001311150.1 → NP_001298079.1 protein mono-ADP-ribosyltransferase PARP3 isoform 1

See identical proteins and their annotated locations for NP_001298079.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AF368233, AK044223, AK147868

Consensus CDS

CCDS81066.1

UniProtKB/Swiss-Prot

A0A1L1SRP6, E9PX17, E9Q992, Q3UGL7, Q3ULW8, Q8BHN6, Q8BXU2, Q8CFB8, Q91YR6

Related

ENSMUSP00000108098.3, ENSMUST00000112479.9

Conserved Domains (2) summary

cd01437
Location:181 → 532

parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...

cl01581
Location:56 → 154

WGR; WGR domain
NM_145619.3 → NP_663594.2 protein mono-ADP-ribosyltransferase PARP3 isoform 2

See identical proteins and their annotated locations for NP_663594.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.

Source sequence(s)

AF368233, AK147868

Consensus CDS

CCDS23480.1

UniProtKB/TrEMBL

Q3UGL7, Q8CFB8

Related

ENSMUSP00000064513.8, ENSMUST00000067218.14

Conserved Domains (2) summary

cd01437
Location:176 → 527

parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...

cl01581
Location:56 → 154

WGR; WGR domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

106347521..106354148 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006511719.4 → XP_006511782.1 protein mono-ADP-ribosyltransferase PARP3 isoform X1

See identical proteins and their annotated locations for XP_006511782.1

UniProtKB/Swiss-Prot

A0A1L1SRP6, E9PX17, E9Q992, Q3UGL7, Q3ULW8, Q8BHN6, Q8BXU2, Q8CFB8, Q91YR6

Conserved Domains (2) summary

cd01437
Location:181 → 532

parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...

cl01581
Location:56 → 154

WGR; WGR domain
XM_006511720.2 → XP_006511783.1 protein mono-ADP-ribosyltransferase PARP3 isoform X2

See identical proteins and their annotated locations for XP_006511783.1

UniProtKB/TrEMBL

Q8CFB8

Related

ENSMUSP00000123054.2, ENSMUST00000123555.8

Conserved Domains (2) summary

cd01437
Location:176 → 527

parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...

cl01581
Location:56 → 154

WGR; WGR domain
XM_006511718.1 → XP_006511781.1 protein mono-ADP-ribosyltransferase PARP3 isoform X1

See identical proteins and their annotated locations for XP_006511781.1

UniProtKB/Swiss-Prot

A0A1L1SRP6, E9PX17, E9Q992, Q3UGL7, Q3ULW8, Q8BHN6, Q8BXU2, Q8CFB8, Q91YR6

Conserved Domains (2) summary

cd01437
Location:181 → 532

parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...

cl01581
Location:56 → 154

WGR; WGR domain