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    Pou2af2 POU domain, class 2, associating factor 2 [ Mus musculus (house mouse) ]

    Gene ID: 69809, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Pou2af2provided by MGI
    Official Full Name
    POU domain, class 2, associating factor 2provided by MGI
    Primary source
    MGI:MGI:1917059
    See related
    Ensembl:ENSMUSG00000036027 AllianceGenome:MGI:1917059
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Oca-t1; 1810046K07Rik
    Summary
    Predicted to enable sequence-specific DNA binding activity and transcription coactivator activity. Predicted to be involved in positive regulation of DNA-templated transcription. Predicted to be located in cytosol. Predicted to be active in nucleus. Orthologous to human POU2AF2 (POU class 2 homeobox associating factor 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in small intestine adult (RPKM 8.8), duodenum adult (RPKM 8.4) and 10 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pou2af2 in Genome Data Viewer
    Location:
    9 A5.3; 9 28.05 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (51200986..51240224, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (51289686..51328924, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6732 Neighboring gene POU domain, class 2, associating factor 1 Neighboring gene STARR-seq mESC enhancer starr_24127 Neighboring gene predicted gene, 32819 Neighboring gene POU class 2 homeobox associating factor 3 Neighboring gene predicted gene, 39338 Neighboring gene STARR-seq mESC enhancer starr_24128 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:51209953-51210278 Neighboring gene STARR-seq mESC enhancer starr_24129 Neighboring gene STARR-seq mESC enhancer starr_24130 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene ribosomal protein L9 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. OCA-T1 and OCA-T2 are coactivators of POU2F3 in the tuft cell lineage. Wu XS, et al. Nature, 2022 Jul. PMID 35576971, Free PMC Article
    2. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. OCA-T1 and OCA-T2 are coactivators of POU2F3 in the tuft cell lineage.
      Title: OCA-T1 and OCA-T2 are coactivators of POU2F3 in the tuft cell lineage.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables POU domain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coactivator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    POU domain class 2-associating factor 2
    Names
    OCA-B homolog
    POU class 2 homeobox-associating factor 2
    oct coactivator from tuft cells 1
    protein POU2AF2
    uncharacterized protein C11orf53 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001372554.1 → NP_001359483.1  POU domain class 2-associating factor 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC122499, AC160052
      Consensus CDS
      CCDS90567.1
      UniProtKB/Swiss-Prot
      A0A5K1VW51, Q9D8Q6
      Related
      ENSMUSP00000158857.3, ENSMUST00000238450.3
      Conserved Domains (1) summary
      pfam17721
      Location:55 → 287
      DUF5566; Family of unknown function (DUF5566)

    2. NM_001372555.1 → NP_001359484.1  POU domain class 2-associating factor 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC122499, AC160052
      Conserved Domains (1) summary
      pfam17721
      Location:54 → 286
      DUF5566; Family of unknown function (DUF5566)

    3. NM_001372556.1 → NP_001359485.1  POU domain class 2-associating factor 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC122499, AC160052
      Conserved Domains (1) summary
      pfam17721
      Location:54 → 284
      DUF5566; Family of unknown function (DUF5566)

    4. NM_001372557.1 → NP_001359486.1  POU domain class 2-associating factor 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC122499, AC160052
      Consensus CDS
      CCDS52792.1
      Related
      ENSMUSP00000137735.3, ENSMUST00000181366.3
      Conserved Domains (1) summary
      pfam17721
      Location:3 → 235
      DUF5566; Family of unknown function (DUF5566)

    5. NM_027217.2 → NP_081493.1  POU domain class 2-associating factor 2 isoform 4

      See identical proteins and their annotated locations for NP_081493.1

      Status: VALIDATED

      Source sequence(s)
      AC122499, AC160052
      Consensus CDS
      CCDS52792.1
      UniProtKB/Swiss-Prot
      Q9D8Q6
      Related
      ENSMUSP00000036912.5, ENSMUST00000039959.11
      Conserved Domains (1) summary
      pfam17721
      Location:3 → 235
      DUF5566; Family of unknown function (DUF5566)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      51200986..51240224 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006510589.3 → XP_006510652.1  POU domain class 2-associating factor 2 isoform X1

      See identical proteins and their annotated locations for XP_006510652.1

      UniProtKB/Swiss-Prot
      Q9D8Q6
      Conserved Domains (1) summary
      pfam17721
      Location:3 → 235
      DUF5566; Family of unknown function (DUF5566)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D8Q6.2 GenPept UniProtKB/Swiss-Prot:Q9D8Q6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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