Kcng4 potassium voltage-gated channel, subfamily G, member 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kcng4provided by MGI
Official Full Name: potassium voltage-gated channel, subfamily G, member 4provided by MGI
Primary source: MGI:MGI:1913983
See related: Ensembl:ENSMUSG00000045246 AllianceGenome:MGI:1913983
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: KV6.3; KV6.4; 4921535I01Rik
Summary: Predicted to enable delayed rectifier potassium channel activity; potassium channel regulator activity; and transmembrane transporter binding activity. Predicted to be involved in action potential; potassium ion transmembrane transport; and regulation of potassium ion transmembrane transport. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in membrane. Is expressed in central nervous system; gut; male reproductive gland or organ; and retina inner nuclear layer. Orthologous to human KCNG4 (potassium voltage-gated channel modifier subfamily G member 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in cerebellum adult (RPKM 22.8), testis adult (RPKM 5.9) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 E1; 8 68.07 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (120350593..120362497, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (119623854..119635680, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

targeted deletion of Kv6.4 in a transgenic mouse model causes male sterility as offspring from homozygous females were only obtained after mating with wild-type or heterozygous males. sterility of the homozygous males was caused by a severe reduction in total sperm-cell count and the absence of motile spermatozoa in the semen. spermatozoa of homozygous mice showed an abnormal morphology, with smaller head and shorter tail
Title: Targeted deletion of the Kv6.4 subunit causes male sterility due to disturbed spermiogenesis.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (3) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables delayed rectifier potassium channel activity	ISO Inferred from Sequence Orthology more info
enables potassium channel regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables potassium channel regulator activity	ISS Inferred from Sequence or Structural Similarity more info
enables transmembrane transporter binding	IEA Inferred from Electronic Annotation more info
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info
enables voltage-gated potassium channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in action potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in protein homooligomerization	IEA Inferred from Electronic Annotation more info
involved_in regulation of potassium ion transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
part_of voltage-gated potassium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated potassium channel complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: voltage-gated potassium channel regulatory subunit KCNG4; potassium voltage-gated channel subfamily G member 4

Names: voltage-gated potassium channel subunit Kv6.3; voltage-gated potassium channel subunit Kv6.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001357210.1 → NP_001344139.1 voltage-gated potassium channel regulatory subunit KCNG4 isoform 2

Status: VALIDATED

Source sequence(s)

AC104882

Conserved Domains (1) summary

cl38908
Location:58 → 167

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
NM_025734.2 → NP_080010.2 voltage-gated potassium channel regulatory subunit KCNG4 isoform 1

See identical proteins and their annotated locations for NP_080010.2

Status: VALIDATED

Source sequence(s)

BC043936

Consensus CDS

CCDS22710.1

UniProtKB/Swiss-Prot

Q80XM3

Related

ENSMUSP00000056552.4, ENSMUST00000061828.10

Conserved Domains (2) summary

cl38908
Location:58 → 167

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

pfam00520
Location:219 → 463

Ion_trans; Ion transport protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

120350593..120362497 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036154242.1 → XP_036010135.1 potassium voltage-gated channel subfamily G member 4 isoform X3

Conserved Domains (1) summary

cl38908
Location:58 → 167

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
XM_006531289.5 → XP_006531352.1 potassium voltage-gated channel subfamily G member 4 isoform X1

See identical proteins and their annotated locations for XP_006531352.1

UniProtKB/Swiss-Prot

Q80XM3

Conserved Domains (2) summary

cl38908
Location:58 → 167

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

pfam00520
Location:219 → 463

Ion_trans; Ion transport protein
XM_036154241.1 → XP_036010134.1 potassium voltage-gated channel subfamily G member 4 isoform X2

Conserved Domains (1) summary

cl38908
Location:58 → 167

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily