Zfp212 Zinc finger protein 212 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zfp212provided by MGI
Official Full Name: Zinc finger protein 212provided by MGI
Primary source: MGI:MGI:2682609
See related: Ensembl:ENSMUSG00000052763 AllianceGenome:MGI:2682609
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Znf212; mKIAA3011
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including dendrite development; general adaptation syndrome, behavioral process; and walking behavior. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in central nervous system; early conceptus; and genitourinary system. Orthologous to human ZNF212 (zinc finger protein 212). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in thymus adult (RPKM 8.8), ovary adult (RPKM 7.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 B2.3; 6 22.94 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (47897502..47909573)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (47920568..47932639)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of zinc-finger protein 212 leads to Purkinje cell death and locomotive abnormalities with phospholipase D3 downregulation.
Title: Loss of zinc-finger protein 212 leads to Purkinje cell death and locomotive abnormalities with phospholipase D3 downregulation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within dendrite development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within general adaptation syndrome, behavioral process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuromuscular process controlling balance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to alcohol	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within walking behavior	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IC Inferred by Curator more info	PubMed

General protein information

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Preferred Names: zinc finger protein 212

Names: Zinc finger protein C2H2-150

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001145881.1 → NP_001139353.1 zinc finger protein 212 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in an isoform (2) that is 1 aa shorter than isoform 1

Source sequence(s)

AI646736, AK129476, BC064742, CJ054342

UniProtKB/TrEMBL

Q6ZPF1

Conserved Domains (6) summary

cd07765
Location:142 → 180

KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

smart00355
Location:312 → 334

ZnF_C2H2; zinc finger

COG5048
Location:357 → 473

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:367 → 387

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:425 → 445

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:437 → 462

zf-H2C2_2; Zinc-finger double domain
NM_145576.2 → NP_663551.2 zinc finger protein 212 isoform 1

See identical proteins and their annotated locations for NP_663551.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AI646736, AK129476, BC064742, CF915685, CJ054342

Consensus CDS

CCDS51761.1

UniProtKB/TrEMBL

G3X8R7, Q6ZPF1

Related

ENSMUSP00000009411.8, ENSMUST00000009411.9

Conserved Domains (5) summary

cd07765
Location:142 → 180

KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

COG5048
Location:358 → 474

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:368 → 388

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:426 → 446

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:438 → 463

zf-H2C2_2; Zinc-finger double domain