Tecpr1 tectonin beta-propeller repeat containing 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tecpr1provided by MGI
Official Full Name: tectonin beta-propeller repeat containing 1provided by MGI
Primary source: MGI:MGI:1917631
See related: Ensembl:ENSMUSG00000066621 AllianceGenome:MGI:1917631
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mKIAA1358; 2210010N04Rik
Summary: Predicted to enable phosphatidylinositol-3-phosphate binding activity. Predicted to be involved in autophagosome maturation and regulation of autophagosome maturation. Predicted to be located in nucleoplasm. Predicted to be active in autophagosome membrane and lysosomal membrane. Is expressed in several structures, including alimentary system; brain; cochlea; ganglia; and vibrissa follicle. Orthologous to human TECPR1 (tectonin beta-propeller repeat containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 45.0), thymus adult (RPKM 42.1) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 G2; 5 83.07 cM

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (144131260..144160433, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (144194442..144223615, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Although Tecpr1-deficient mice appear normal, Tecpr1-deficient mouse embryo fibroblasts were defective for selective autophagy and supported increased intracellular multiplication of Shigella.
Title: A Tecpr1-dependent selective autophagy pathway targets bacterial pathogens.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables phosphatidylinositol-3-phosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-3-phosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-3-phosphate binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in autophagosome maturation	IBA Inferred from Biological aspect of Ancestor more info
involved_in autophagosome maturation	ISO Inferred from Sequence Orthology more info
involved_in autophagosome maturation	ISS Inferred from Sequence or Structural Similarity more info
involved_in autophagy	ISO Inferred from Sequence Orthology more info
involved_in autophagy	ISS Inferred from Sequence or Structural Similarity more info
involved_in macroautophagy	ISO Inferred from Sequence Orthology more info
involved_in regulation of autophagosome maturation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in autophagosome membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in autophagosome membrane	ISO Inferred from Sequence Orthology more info
located_in autophagosome membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in lysosomal membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: tectonin beta-propeller repeat-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001356992.1 → NP_001343921.1 tectonin beta-propeller repeat-containing protein 1 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice junction compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.

Source sequence(s)

AC139636

Conserved Domains (5) summary

smart00694
Location:369 → 402

DysFC; Dysferlin domain, C-terminal region

smart00693
Location:297 → 358

DysFN; Dysferlin domain, N-terminal region

smart00706
Location:242 → 275

TECPR; Beta propeller repeats in Physarum polycephalum tectonins, Limulus lectin L-6 and animal hypothetical proteins

cd13300
Location:85 → 205

PH1_TECPR1; Tectonin beta-propeller repeat-containing protein 1 Pleckstrin homology (PH) domain, repeat 1

pfam19193
Location:431 → 573

Tectonin; Tectonin domain
NM_001356993.1 → NP_001343922.1 tectonin beta-propeller repeat-containing protein 1 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses two alternate splice junctions compared to variant 1. The resulting isoform (3) is shorter at the N-terminus and lacks an internal segment compared to isoform 1.

Source sequence(s)

AC139636

Conserved Domains (5) summary

smart00694
Location:364 → 397

DysFC; Dysferlin domain, C-terminal region

smart00693
Location:292 → 353

DysFN; Dysferlin domain, N-terminal region

smart00706
Location:545 → 570

TECPR; Beta propeller repeats in Physarum polycephalum tectonins, Limulus lectin L-6 and animal hypothetical proteins

cd13300
Location:80 → 200

PH1_TECPR1; Tectonin beta-propeller repeat-containing protein 1 Pleckstrin homology (PH) domain, repeat 1

pfam06462
Location:522 → 550

Hyd_WA; Propeller
NM_027410.2 → NP_081686.1 tectonin beta-propeller repeat-containing protein 1 isoform 1

See identical proteins and their annotated locations for NP_081686.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AC139636, AK040462, AW048569, BC046968

Consensus CDS

CCDS39377.1

UniProtKB/Swiss-Prot

Q80VP0, Q8CHA3, Q8R3E0, Q99KQ5, Q9CVC6

Related

ENSMUSP00000082844.7, ENSMUST00000085701.7

Conserved Domains (6) summary

smart00694
Location:893 → 926

DysFC; Dysferlin domain, C-terminal region

smart00693
Location:64 → 125

DysFN; Dysferlin domain, N-terminal region

smart00706
Location:234 → 270

TECPR; Beta propeller repeats in Physarum polycephalum tectonins, Limulus lectin L-6 and animal hypothetical proteins

cd13300
Location:609 → 729

PH1_TECPR1; Tectonin beta-propeller repeat-containing protein 1 Pleckstrin homology (PH) domain, repeat 1

pfam00169
Location:615 → 721

PH; PH domain

pfam06462
Location:303 → 331

Hyd_WA; Propeller

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

144131260..144160433 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006504864.5 → XP_006504927.1 tectonin beta-propeller repeat-containing protein 1 isoform X1

Conserved Domains (5) summary

smart00694
Location:762 → 795

DysFC; Dysferlin domain, C-terminal region

smart00693
Location:690 → 751

DysFN; Dysferlin domain, N-terminal region

smart00706
Location:103 → 139

TECPR; Beta propeller repeats in Physarum polycephalum tectonins, Limulus lectin L-6 and animal hypothetical proteins

cd13300
Location:478 → 598

PH1_TECPR1; Tectonin beta-propeller repeat-containing protein 1 Pleckstrin homology (PH) domain, repeat 1

pfam06462
Location:171 → 200

Hyd_WA; Propeller
XM_036165488.1 → XP_036021381.1 tectonin beta-propeller repeat-containing protein 1 isoform X2

Conserved Domains (5) summary

smart00694
Location:369 → 402

DysFC; Dysferlin domain, C-terminal region

smart00693
Location:297 → 358

DysFN; Dysferlin domain, N-terminal region

smart00706
Location:242 → 275

TECPR; Beta propeller repeats in Physarum polycephalum tectonins, Limulus lectin L-6 and animal hypothetical proteins

cd13300
Location:85 → 205

PH1_TECPR1; Tectonin beta-propeller repeat-containing protein 1 Pleckstrin homology (PH) domain, repeat 1

pfam19193
Location:431 → 573

Tectonin; Tectonin domain