Dmrta1 doublesex and mab-3 related transcription factor like family A1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dmrta1provided by MGI
Official Full Name: doublesex and mab-3 related transcription factor like family A1provided by MGI
Primary source: MGI:MGI:2653627
See related: Ensembl:ENSMUSG00000043753 AllianceGenome:MGI:2653627
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Dmrt4
Summary: Enables identical protein binding activity and sequence-specific DNA binding activity. Acts upstream of or within male mating behavior and ovarian follicle development. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; dorsal root ganglion; genitourinary system; gut; and liver. Orthologous to human DMRTA1 (DMRT like family A1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in testis adult (RPKM 2.2), CNS E11.5 (RPKM 1.3) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 C4; 4 42.15 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (89576435..89583003)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (89688198..89694766)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation
Targeted (2) 1 citation

General gene information

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Markers

Dmrta1 (e-PCR), detects polymorphism
- UniSTS:257212

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific double-stranded DNA binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within male mating behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ovarian follicle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in sex differentiation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: doublesex- and mab-3-related transcription factor A1

Names: doublesex and mab-3 related transcription factor 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_175647.3 → NP_783578.1 doublesex- and mab-3-related transcription factor A1

See identical proteins and their annotated locations for NP_783578.1

Status: PROVISIONAL

Source sequence(s)

AL772403

Consensus CDS

CCDS18352.1

UniProtKB/Swiss-Prot

A2AL09, Q8CFG4

UniProtKB/TrEMBL

B2RPV0

Related

ENSMUSP00000057488.3, ENSMUST00000052478.3

Conserved Domains (2) summary

pfam00751
Location:82 → 128

DM; DM DNA binding domain

pfam03474
Location:315 → 350

DMA; DMRTA motif