Capza1 capping actin protein of muscle Z-line subunit alpha 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Capza1provided by MGI
Official Full Name: capping actin protein of muscle Z-line subunit alpha 1provided by MGI
Primary source: MGI:MGI:106227
See related: Ensembl:ENSMUSG00000070372 AllianceGenome:MGI:106227
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CAPZ; CAZ1; Cappa1; capZ alpha-1
Summary: Contributes to actin filament binding activity. Acts upstream of or within barbed-end actin filament capping. Located in several cellular components, including brush border; cell-cell junction; and cortical cytoskeleton. Part of F-actin capping protein complex. Is expressed in early conceptus; head mesenchyme; and lung. Orthologous to human CAPZA1 (capping actin protein of muscle Z-line subunit alpha 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in placenta adult (RPKM 33.2), testis adult (RPKM 31.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F2.2; 3 45.88 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (104730097..104771821, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (104822781..104864505, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The temporal association of CapZ with early endosomes regulates endosomal trafficking and viral entry into host cells.
Title: The temporal association of CapZ with early endosomes regulates endosomal trafficking and viral entry into host cells.
Comparative Analysis of CPI-Motif Regulation of Biochemical Functions of Actin Capping Protein.
Title: Comparative Analysis of CPI-Motif Regulation of Biochemical Functions of Actin Capping Protein.
Here, the authors discover that the C-terminal tail of Twinfilin harbors a capping protein-interacting (CPI) motif, identifying it as a novel CPI-motif protein. Twinfilin binds competitively with CARMIL to capping protein, protecting capping protein from barbed-end displacement by CARMIL.
Title: A novel mode of capping protein-regulation by twinfilin.
These data further support the concept that the cardiac Z-disc protein is a regulator of myofilament function and intracellular signalling transduction.
Title: Identifying a role of the actin capping protein CapZ in β-adrenergic receptor signalling.
Actin-capping protein is a novel regulator of microtubule stability that functions by antagonizing mDia1 activity toward actin filaments.
Title: Actin-capping protein promotes microtubule stability by antagonizing the actin activity of mDia1.
Results demonstrate myofilament regulation by protein phosphatase type 1 alpha and CapZ, and support the concept that cardiac Z-discs are vital components in intracellular signalling.
Title: Cardiac myofilament regulation by protein phosphatase type 1alpha and CapZ.
Mouse homolog of the adaptor protein CARMIL (mCARMIL) binds CP with high affinity and decreases its affinity for the barbed end
Title: Mammalian CARMIL inhibits actin filament capping by capping protein.
CKIP-1 has a role in cell morphology that depends on its interaction with actin-capping protein
Title: The role of CKIP-1 in cell morphology depends on its interaction with actin-capping protein.
actin-capping protein binds to the filament barbed end of myotrophin/V-1
Title: Binding of myotrophin/V-1 to actin-capping protein: implications for how capping protein binds to the filament barbed end.
CapZ is an important component in anchoring PKC-beta(II) at the myofilaments, and for mediating the effects of PKC-beta(II) on myofilament function
Title: Control of cardiac myofilament activation and PKC-betaII signaling through the actin capping protein, CapZ.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Capza1 (e-PCR), detects polymorphism
- UniSTS:499171

U16740 (e-PCR)
- UniSTS:125684

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
contributes_to actin filament binding	IDA Inferred from Direct Assay more info	PubMed
contributes_to protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in barbed-end actin filament capping	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within barbed-end actin filament capping	IDA Inferred from Direct Assay more info	PubMed
involved_in cell junction assembly	ISO Inferred from Sequence Orthology more info
involved_in cell junction assembly	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of F-actin capping protein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of F-actin capping protein complex	IDA Inferred from Direct Assay more info	PubMed
part_of WASH complex	ISO Inferred from Sequence Orthology more info
part_of WASH complex	ISS Inferred from Sequence or Structural Similarity more info
located_in brush border	IDA Inferred from Direct Assay more info	PubMed
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in cortical cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in cortical cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: F-actin-capping protein subunit alpha-1

Names: F-actin capping protein alpha-1 subunit; capping protein (actin filament) muscle Z-line, alpha 1; capping protein alpha 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001355044.1 → NP_001341973.1 F-actin-capping protein subunit alpha-1 isoform 2

Status: VALIDATED

Source sequence(s)

AC171110

Conserved Domains (1) summary

pfam01267
Location:17 → 214

F-actin_cap_A; F-actin capping protein alpha subunit
NM_009797.3 → NP_033927.2 F-actin-capping protein subunit alpha-1 isoform 1

See identical proteins and their annotated locations for NP_033927.2

Status: VALIDATED

Source sequence(s)

AK147049, AK161370, BC085506, BY442029, U16740

Consensus CDS

CCDS38580.1

UniProtKB/Swiss-Prot

P47753, Q91YN7

UniProtKB/TrEMBL

Q3UAS2, Q5RKN9

Related

ENSMUSP00000102381.4, ENSMUST00000094028.10

Conserved Domains (1) summary

pfam01267
Location:14 → 282

F-actin_cap_A; F-actin capping protein alpha subunit