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    Trmt112 tRNA methyltransferase 11-2 [ Mus musculus (house mouse) ]

    Gene ID: 67674, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Trmt112provided by MGI
    Official Full Name
    tRNA methyltransferase 11-2provided by MGI
    Primary source
    MGI:MGI:1914924
    See related
    Ensembl:ENSMUSG00000038812 AllianceGenome:MGI:1914924
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Trm112p; 0610038D11Rik
    Summary
    Predicted to enable protein heterodimerization activity; protein methyltransferase activity; and tRNA methyltransferase activator activity. Involved in peptidyl-glutamine methylation. Predicted to be located in nucleoplasm and perinuclear region of cytoplasm. Predicted to be part of tRNA (m2G10) methyltransferase complex. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including brain; gut; limb bud; lung; and sensory organ. Orthologous to human TRMT112 (tRNA methyltransferase activator subunit 11-2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 69.5), adrenal adult (RPKM 52.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Trmt112 in Genome Data Viewer
    Location:
    19 A; 19 5.08 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (6887066..6888396)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (6909698..6911028)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 88B Neighboring gene predicted gene, 54051 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:6946569-6946770 Neighboring gene peroxiredoxin 5 Neighboring gene estrogen related receptor, alpha Neighboring gene microRNA 6990 Neighboring gene STARR-positive B cell enhancer ABC_E780 Neighboring gene cation channel sperm associated auxiliary subunit zeta

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Trmt112 gene expression in mouse embryonic development. Gu T, et al. Acta Histochem Cytochem, 2012 Apr 26. PMID 22685353, Free PMC Article
    2. Substrate Specificity of the HEMK2 Protein Glutamine Methyltransferase and Identification of Novel Substrates. Kusevic D, et al. J Biol Chem, 2016 Mar 18. PMID 26797129, Free PMC Article
    3. A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. Mural RJ, et al. Science, 2002 May 31. PMID 12040188
    4. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article
    5. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein heterodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables tRNA methyltransferase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA methyltransferase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA methyltransferase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in maturation of LSU-rRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maturation of SSU-rRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peptidyl-glutamine methylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in peptidyl-glutamine methylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of rRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of rRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of rRNA processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in rRNA (guanine-N7)-methylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in rRNA (guanine-N7)-methylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in rRNA methylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in rRNA methylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in tRNA methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA methylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transcription initiation-coupled chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transcription initiation-coupled chromatin remodeling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    part_of tRNA (m2G10) methyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    multifunctional methyltransferase subunit TRM112-like protein
    Names
    TRM112-like protein
    tRNA methyltransferase 11-2 homolog
    tRNA methyltransferase 112 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166370.1 → NP_001159842.1  multifunctional methyltransferase subunit TRM112-like protein

      See identical proteins and their annotated locations for NP_001159842.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer and more frequently occurring transcript. Both variants encode the same protein.
      Source sequence(s)
      BC087959, BE951374, DV654053
      Consensus CDS
      CCDS29508.1
      UniProtKB/Swiss-Prot
      Q91YP8, Q9D1N6, Q9DCG9
      UniProtKB/TrEMBL
      Q5M8M3
      Related
      ENSMUSP00000112250.4, ENSMUST00000116551.10
      Conserved Domains (1) summary
      pfam03966
      Location:86 → 112
      Trm112p; Trm112p-like protein

    2. NM_026306.3 → NP_080582.3  multifunctional methyltransferase subunit TRM112-like protein

      See identical proteins and their annotated locations for NP_080582.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks a segment in the 5' UTR, compared to variant 1. Both variants encode the same protein.
      Source sequence(s)
      BC087959, BE951374
      Consensus CDS
      CCDS29508.1
      UniProtKB/Swiss-Prot
      Q91YP8, Q9D1N6, Q9DCG9
      UniProtKB/TrEMBL
      Q5M8M3
      Related
      ENSMUSP00000085591.8, ENSMUST00000088257.14
      Conserved Domains (1) summary
      pfam03966
      Location:86 → 112
      Trm112p; Trm112p-like protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      6887066..6888396
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DCG9.1 GenPept UniProtKB/Swiss-Prot:Q9DCG9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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