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    Naa30 N(alpha)-acetyltransferase 30, NatC catalytic subunit [ Mus musculus (house mouse) ]

    Gene ID: 70646, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Naa30provided by MGI
    Official Full Name
    N(alpha)-acetyltransferase 30, NatC catalytic subunitprovided by MGI
    Primary source
    MGI:MGI:1922259
    See related
    Ensembl:ENSMUSG00000036282 AllianceGenome:MGI:1922259
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nat12; 4930487N19Rik; 5730533P17Rik
    Summary
    Predicted to enable peptide alpha-N-acetyltransferase activity. Predicted to be involved in protein stabilization. Predicted to be located in cytosol and nucleus. Predicted to be part of NatC complex. Orthologous to human NAA30 (N-alpha-acetyltransferase 30, NatC catalytic subunit). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 8.0), whole brain E14.5 (RPKM 7.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Naa30 in Genome Data Viewer
    Location:
    14 C1; 14 25.42 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (49409703..49428346)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (49172246..49190889)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene exocyst complex component 5 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:49686153-49686414 Neighboring gene adaptor-related protein complex 5, mu 1 subunit Neighboring gene VISTA enhancer mm1570 Neighboring gene STARR-seq mESC enhancer starr_36626 Neighboring gene ribosomal protein L19, pseudogene 3 Neighboring gene STARR-seq mESC enhancer starr_36627 Neighboring gene coiled-coil domain containing 198 Neighboring gene STARR-seq mESC enhancer starr_36630 Neighboring gene solute carrier family 35, member F4 Neighboring gene STARR-seq mESC enhancer starr_36631 Neighboring gene predicted gene, 52146

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase. Groh BS, et al. EMBO Rep, 2016 May. PMID 27113764, Free PMC Article
    2. Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo. Harrison SM, et al. Development, 1995 Aug. PMID 7671812
    3. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables peptide alpha-N-acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptide alpha-N-acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptide alpha-N-acetyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables peptide-methionine-alpha-N-acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein stabilization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of NatC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of NatC complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of NatC complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    N-alpha-acetyltransferase 30
    Names
    N-acetyltransferase 12
    N-acetyltransferase MAK3 homolog
    Nalpha acetyltransferase 30
    natC catalytic subunit
    NP_081768.2
    XP_006519605.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027492.2 → NP_081768.2  N-alpha-acetyltransferase 30

      Status: VALIDATED

      Source sequence(s)
      AC154227, AK015640, BC158065
      Consensus CDS
      CCDS84137.1
      UniProtKB/Swiss-Prot
      B2RY23, Q7TN07, Q8CES0
      UniProtKB/TrEMBL
      B2RXP7
      Related
      ENSMUSP00000121679.2, ENSMUST00000153488.9
      Conserved Domains (2) summary
      COG0456
      Location:211 → 364
      RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]
      pfam00583
      Location:283 → 341
      Acetyltransf_1; Acetyltransferase (GNAT) family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      49409703..49428346
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006519542.5 → XP_006519605.1  N-alpha-acetyltransferase 30 isoform X1

      UniProtKB/TrEMBL
      B2RXP7
      Related
      ENSMUSP00000041450.6, ENSMUST00000037362.6
      Conserved Domains (1) summary
      COG0456
      Location:222 → 375
      RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001081430.1: Suppressed sequence

      Description
      NM_001081430.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CES0.2 GenPept UniProtKB/Swiss-Prot:Q8CES0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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