Asgr2 asialoglycoprotein receptor 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Asgr2provided by MGI
Official Full Name: asialoglycoprotein receptor 2provided by MGI
Primary source: MGI:MGI:88082
See related: Ensembl:ENSMUSG00000040963 AllianceGenome:MGI:88082
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Asgr; HL-2; ASGPR2; Asgr-2
Summary: This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the less abundant minor subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene [provided by RefSeq, Sep 2015]
Expression: Biased expression in liver adult (RPKM 69.1), liver E18 (RPKM 23.8) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B3; 11 42.99 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (69983470..69997013)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (70092644..70106187)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Enhanced ASGR2 by microplastic exposure leads to resistance to therapy in gastric cancer.
Title: Enhanced ASGR2 by microplastic exposure leads to resistance to therapy in gastric cancer.
the key roles of the ManR and ASGR in controlling circulating levels of numerous glycoproteins critical for regulating reproductive hormones and blood coagulation.
Title: Functional Consequences of Mannose and Asialoglycoprotein Receptor Ablation.
found that the asialoglycoprotein receptor (ASGPR) is involved in hepatocyte recognition of cells predestined for killing, including activated autologous T lymphocytes
Title: Hepatocyte cytotoxicity is facilitated by asialoglycoprotein receptor.
ASGP-R2 mediates the clearance of glycoproteins that bear oligosaccharides terminating with Siaalpha2,6Gal and thereby helps maintain the relative concentrations of these glycoproteins in the blood.
Title: The asialoglycoprotein receptor regulates levels of plasma glycoproteins terminating with sialic acid alpha2,6-galactose.
The Ashwell receptor is composed of type 2 transmembrane glycoproteins termed Asgr1 and Asgr2. Both are predominantly expressed in the liver.
Title: The Ashwell receptor mitigates the lethal coagulopathy of sepsis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Asgr2 (e-PCR), detects polymorphism
- UniSTS:532417

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables D-mannose binding	IBA Inferred from Biological aspect of Ancestor more info
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables fucose binding	IBA Inferred from Biological aspect of Ancestor more info
enables pattern recognition receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in bone mineralization	IEA Inferred from Electronic Annotation more info
involved_in endocytosis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glycoprotein metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lipid homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of protein stability	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum quality control compartment	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: asialoglycoprotein receptor 2

Names: hepatic lectin 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001313925.1 → NP_001300854.1 asialoglycoprotein receptor 2 isoform a

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1, 2, and 3 all encode the same isoform (a).

Source sequence(s)

AI227223, AL596185, X53042

Consensus CDS

CCDS24934.1

UniProtKB/Swiss-Prot

P24721

Conserved Domains (2) summary

cd03590
Location:170 → 295

CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)

pfam03954
Location:29 → 162

Lectin_N; Hepatic lectin, N-terminal domain
NM_001313926.1 → NP_001300855.1 asialoglycoprotein receptor 2 isoform a

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same isoform (a).

Source sequence(s)

AL596185, X53042

Consensus CDS

CCDS24934.1

UniProtKB/Swiss-Prot

P24721

Conserved Domains (2) summary

cd03590
Location:170 → 295

CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)

pfam03954
Location:29 → 162

Lectin_N; Hepatic lectin, N-terminal domain
NM_001313927.1 → NP_001300856.1 asialoglycoprotein receptor 2 isoform b

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (b) with a shorter N-terminus compared to isoform a.

Source sequence(s)

AL596185, X53042

UniProtKB/TrEMBL

J3QMY0

Related

ENSMUSP00000136505.2, ENSMUST00000143772.8

Conserved Domains (2) summary

cd03590
Location:67 → 192

CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)

pfam03954
Location:1 → 59

Lectin_N; Hepatic lectin, N-terminal domain
NM_007493.3 → NP_031519.1 asialoglycoprotein receptor 2 isoform a

See identical proteins and their annotated locations for NP_031519.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same isoform (a).

Source sequence(s)

AL596185

Consensus CDS

CCDS24934.1

UniProtKB/Swiss-Prot

P24721

Related

ENSMUSP00000099632.2, ENSMUST00000102572.8

Conserved Domains (2) summary

cd03590
Location:170 → 295

CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)

pfam03954
Location:29 → 162

Lectin_N; Hepatic lectin, N-terminal domain