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    Rgs8 regulator of G-protein signaling 8 [ Mus musculus (house mouse) ]

    Gene ID: 67792, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Rgs8provided by MGI
    Official Full Name
    regulator of G-protein signaling 8provided by MGI
    Primary source
    MGI:MGI:108408
    See related
    Ensembl:ENSMUSG00000042671 AllianceGenome:MGI:108408
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    6530413N01Rik
    Summary
    Predicted to enable G-protein alpha-subunit binding activity and GTPase activator activity. Predicted to be involved in G protein-coupled acetylcholine receptor signaling pathway; positive regulation of GTPase activity; and regulation of dopamine receptor signaling pathway. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in several cellular components, including cytoplasmic side of plasma membrane; dendrite; and neuronal cell body membrane. Is expressed in central nervous system and retina. Orthologous to human RGS8 (regulator of G protein signaling 8). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 84.0), cortex adult (RPKM 9.6) and 4 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rgs8 in Genome Data Viewer
    Location:
    1 G3; 1 65.41 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (153528612..153573415)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (153652959..153697669)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_02701 Neighboring gene N-acetylneuraminate pyruvate lyase Neighboring gene STARR-seq mESC enhancer starr_02703 Neighboring gene STARR-seq mESC enhancer starr_02704 Neighboring gene STARR-seq mESC enhancer starr_02705 Neighboring gene predicted gene 6652 Neighboring gene STARR-positive B cell enhancer mm9_chr1:155538364-155538664 Neighboring gene STARR-positive B cell enhancer mm9_chr1:155543174-155543475 Neighboring gene RIKEN cDNA C230024C17 gene Neighboring gene regulator of G-protein signaling 16

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Depression-resistant Phenotype in Mice Overexpressing Regulator of G Protein Signaling 8 (RGS8). Kobayashi Y, et al. Neuroscience, 2018 Jul 15. PMID 29758252
    2. Structure of the Regulator of G Protein Signaling 8 (RGS8)-Gαq Complex: MOLECULAR BASIS FOR Gα SELECTIVITY. Taylor VG, et al. J Biol Chem, 2016 Mar 4. PMID 26755720, Free PMC Article
    3. Generation of RGS8 null mutant mice by Cre/loxP system. Kuwata H, et al. Kobe J Med Sci, 2008 Feb 8. PMID 18762722
    4. Ataxin-2 regulates RGS8 translation in a new BAC-SCA2 transgenic mouse model. Dansithong W, et al. PLoS Genet, 2015 Apr. PMID 25902068, Free PMC Article
    5. Altered Purkinje cell miRNA expression and SCA1 pathogenesis. Rodriguez-Lebron E, et al. Neurobiol Dis, 2013 Jun. PMID 23376683, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. these findings suggest that RGS8 participates in modulation of depression-like behavior
      Title: Depression-resistant Phenotype in Mice Overexpressing Regulator of G Protein Signaling 8 (RGS8).
    2. the crystal structure of RGS8 was determined in complex with Galphaq.
      Title: Structure of the Regulator of G Protein Signaling 8 (RGS8)-Gαq Complex: MOLECULAR BASIS FOR Gα SELECTIVITY.
    3. ATXN2 interacted selectively with RGS8 mRNA. This interaction was impaired when ATXN2 harbored an expanded polyglutamine. Mutant ATXN2 also reduced RGS8 expression in an in vitro coupled translation
      Title: Ataxin-2 regulates RGS8 translation in a new BAC-SCA2 transgenic mouse model.
    4. increased miR-150 levels in Spinocerebellar ataxia type 1 Purkinje neurons may modulate disease pathogenesis by targeting the expression of Rgs8 and Vegfa.
      Title: Altered Purkinje cell miRNA expression and SCA1 pathogenesis.
    5. RGS8 null mutant mice were viable, fertile and showed apparently normal development
      Title: Generation of RGS8 null mutant mice by Cre/loxP system.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G-protein alpha-subunit binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTPase activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables GTPase activator activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled acetylcholine receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in G protein-coupled acetylcholine receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of dopamine receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of dopamine receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic side of plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendrite ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in neuronal cell body membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuronal cell body membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    regulator of G-protein signaling 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347115.1 → NP_001334044.1  regulator of G-protein signaling 8 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC154140, CF741546
      Consensus CDS
      CCDS83607.1
      UniProtKB/TrEMBL
      D3Z289
      Related
      ENSMUSP00000107445.2, ENSMUST00000111814.8
      Conserved Domains (1) summary
      cd08711
      Location:44 → 168
      RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein

    2. NM_001357525.1 → NP_001344454.1  regulator of G-protein signaling 8 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC154140
      Consensus CDS
      CCDS15375.1
      UniProtKB/Swiss-Prot
      Q505F2, Q8BXT1
      Related
      ENSMUSP00000107443.2, ENSMUST00000111812.8
      Conserved Domains (1) summary
      cd08711
      Location:46 → 170
      RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein

    3. NM_026380.3 → NP_080656.2  regulator of G-protein signaling 8 isoform 1

      See identical proteins and their annotated locations for NP_080656.2

      Status: VALIDATED

      Source sequence(s)
      BC065056, BY292997
      Consensus CDS
      CCDS15375.1
      UniProtKB/Swiss-Prot
      Q505F2, Q8BXT1
      Related
      ENSMUSP00000045715.6, ENSMUST00000041776.12
      Conserved Domains (1) summary
      cd08711
      Location:46 → 170
      RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      153528612..153573415
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529822.5 → XP_006529885.1  regulator of G-protein signaling 8 isoform X2

      See identical proteins and their annotated locations for XP_006529885.1

      UniProtKB/TrEMBL
      D3Z289
      Conserved Domains (1) summary
      cd08711
      Location:44 → 168
      RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein

    2. XM_006529829.5 → XP_006529892.1  regulator of G-protein signaling 8 isoform X3

      Conserved Domains (1) summary
      cl02565
      Location:10 → 134
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    3. XM_006529821.3 → XP_006529884.1  regulator of G-protein signaling 8 isoform X1

      See identical proteins and their annotated locations for XP_006529884.1

      UniProtKB/Swiss-Prot
      Q505F2, Q8BXT1
      Conserved Domains (1) summary
      cd08711
      Location:46 → 170
      RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein

    4. XM_006529826.4 → XP_006529889.1  regulator of G-protein signaling 8 isoform X2

      See identical proteins and their annotated locations for XP_006529889.1

      UniProtKB/TrEMBL
      D3Z289
      Conserved Domains (1) summary
      cd08711
      Location:44 → 168
      RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein

    5. XM_030242505.1 → XP_030098365.1  regulator of G-protein signaling 8 isoform X1

      UniProtKB/Swiss-Prot
      Q505F2, Q8BXT1
      Related
      ENSMUSP00000107441.2, ENSMUST00000111810.2
      Conserved Domains (1) summary
      cd08711
      Location:46 → 170
      RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein

    6. XM_006529828.3 → XP_006529891.1  regulator of G-protein signaling 8 isoform X2

      See identical proteins and their annotated locations for XP_006529891.1

      UniProtKB/TrEMBL
      D3Z289
      Related
      ENSMUSP00000107446.2, ENSMUST00000111815.8
      Conserved Domains (1) summary
      cd08711
      Location:44 → 168
      RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein

    7. XM_030242507.2 → XP_030098367.1  regulator of G-protein signaling 8 isoform X1

      UniProtKB/Swiss-Prot
      Q505F2, Q8BXT1
      Conserved Domains (1) summary
      cd08711
      Location:46 → 170
      RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein

    8. XM_006529827.4 → XP_006529890.1  regulator of G-protein signaling 8 isoform X2

      See identical proteins and their annotated locations for XP_006529890.1

      UniProtKB/TrEMBL
      D3Z289
      Conserved Domains (1) summary
      cd08711
      Location:44 → 168
      RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein

    9. XM_006529825.4 → XP_006529888.1  regulator of G-protein signaling 8 isoform X2

      See identical proteins and their annotated locations for XP_006529888.1

      UniProtKB/TrEMBL
      D3Z289
      Conserved Domains (1) summary
      cd08711
      Location:44 → 168
      RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein

    10. XM_006529824.5 → XP_006529887.1  regulator of G-protein signaling 8 isoform X2

      See identical proteins and their annotated locations for XP_006529887.1

      UniProtKB/TrEMBL
      D3Z289
      Conserved Domains (1) summary
      cd08711
      Location:44 → 168
      RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein

    11. XM_006529818.5 → XP_006529881.1  regulator of G-protein signaling 8 isoform X1

      See identical proteins and their annotated locations for XP_006529881.1

      UniProtKB/Swiss-Prot
      Q505F2, Q8BXT1
      Conserved Domains (1) summary
      cd08711
      Location:46 → 170
      RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein

    12. XM_006529820.5 → XP_006529883.1  regulator of G-protein signaling 8 isoform X1

      See identical proteins and their annotated locations for XP_006529883.1

      UniProtKB/Swiss-Prot
      Q505F2, Q8BXT1
      Conserved Domains (1) summary
      cd08711
      Location:46 → 170
      RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein

    13. XM_036153199.1 → XP_036009092.1  regulator of G-protein signaling 8 isoform X3

      Conserved Domains (1) summary
      cl02565
      Location:10 → 134
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    14. XM_036153183.1 → XP_036009076.1  regulator of G-protein signaling 8 isoform X1

      UniProtKB/Swiss-Prot
      Q505F2, Q8BXT1
      Conserved Domains (1) summary
      cd08711
      Location:46 → 170
      RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BXT1.1 GenPept UniProtKB/Swiss-Prot:Q8BXT1

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