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    Gpr137 G protein-coupled receptor 137 [ Mus musculus (house mouse) ]

    Gene ID: 107173, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Gpr137provided by MGI
    Official Full Name
    G protein-coupled receptor 137provided by MGI
    Primary source
    MGI:MGI:2147529
    See related
    Ensembl:ENSMUSG00000024958 AllianceGenome:MGI:2147529
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to be involved in several processes, including negative regulation of bone resorption; negative regulation of osteoclast differentiation; and positive regulation of TORC1 signaling. Predicted to be active in lysosomal membrane. Is expressed in 1st branchial arch mandibular component; facial prominence; and nervous system. Orthologous to human GPR137 (G protein-coupled receptor 137). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in testis adult (RPKM 48.3), adrenal adult (RPKM 46.6) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gpr137 in Genome Data Viewer
    Location:
    19 A; 19 5.09 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (6915425..6919818, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (6938057..6942450, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene cation channel sperm associated auxiliary subunit zeta Neighboring gene potassium channel, subfamily K, member 4 Neighboring gene STARR-positive B cell enhancer ABC_E4264 Neighboring gene STARR-positive B cell enhancer ABC_E9991 Neighboring gene STARR-positive B cell enhancer ABC_E8734 Neighboring gene BCL2-associated agonist of cell death Neighboring gene ATG2 autophagy related 2 homolog A pseudogene Neighboring gene phospholipase C, beta 3 Neighboring gene predicted gene, 52400

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. GPR137 Inhibits Cell Proliferation and Promotes Neuronal Differentiation in the Neuro2a Cells. Iwasa K, et al. Neurochem Res, 2023 Mar. PMID 36436172, Free PMC Article
    2. GPR137 inactivates Hippo signaling to promote gastric cancer cell malignancy. Li L, et al. Biol Direct, 2024 Jan 2. PMID 38163861, Free PMC Article
    3. An Alternative Splicing Program for Mouse Craniofacial Development. Hooper JE, et al. Front Physiol, 2020. PMID 33013468, Free PMC Article
    4. Cleft lip and cleft palate in Esrp1 knockout mice is associated with alterations in epithelial-mesenchymal crosstalk. Lee S, et al. Development, 2020 Apr 30. PMID 32253237, Free PMC Article
    5. The G protein-coupled receptor repertoires of human and mouse. Vassilatis DK, et al. Proc Natl Acad Sci U S A, 2003 Apr 15. PMID 12679517, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GPR137 inactivates Hippo signaling to promote gastric cancer cell malignancy.
      Title: GPR137 inactivates Hippo signaling to promote gastric cancer cell malignancy.
    2. GPR137 Inhibits Cell Proliferation and Promotes Neuronal Differentiation in the Neuro2a Cells.
      Title: GPR137 Inhibits Cell Proliferation and Promotes Neuronal Differentiation in the Neuro2a Cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of bone resorption IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of osteoclast differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of TORC1 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of autophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in lysosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosomal membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    integral membrane protein GPR137
    Names
    G protein-coupled receptor TM7SF1L1
    transmembrane 7 superfamily member 1-like 1 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177360.2 → NP_001170831.1  integral membrane protein GPR137 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC120557, AK142928, BC048078, CX200961
      Consensus CDS
      CCDS50371.1
      UniProtKB/TrEMBL
      E9Q9I0, Q3UQ21
      Related
      ENSMUSP00000097364.5, ENSMUST00000099776.6

    2. NM_001177361.2 → NP_001170832.1  integral membrane protein GPR137 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC120557, AK143450
      Consensus CDS
      CCDS50372.1
      UniProtKB/TrEMBL
      Q3UPL3
      Related
      ENSMUSP00000097370.4, ENSMUST00000099782.10

    3. NM_001177362.2 → NP_001170833.1  integral membrane protein GPR137 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC120557
      Consensus CDS
      CCDS50370.1
      UniProtKB/TrEMBL
      Q3TD99
      Related
      ENSMUSP00000097362.4, ENSMUST00000099774.10
      Conserved Domains (2) summary
      cd21464
      Location:38 → 60
      7tm_GPR137; TM helix 6 [structural motif]
      cl28897
      Location:30 → 143
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    4. NM_001379534.1 → NP_001366463.1  integral membrane protein GPR137 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC120557
      Conserved Domains (1) summary
      cd21474
      Location:16 → 352
      7tm_GPR137A; Integral membrane protein GPR137A, an orphan receptor member of the seven-transmembrane G protein-coupled receptor superfamily

    5. NM_001379535.1 → NP_001366464.1  integral membrane protein GPR137 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC120557
      UniProtKB/TrEMBL
      Q3TD99
      Conserved Domains (2) summary
      cd21464
      Location:38 → 60
      7tm_GPR137; TM helix 6 [structural motif]
      cl28897
      Location:30 → 143
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    6. NM_001379536.1 → NP_001366465.1  integral membrane protein GPR137 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC120557
      UniProtKB/TrEMBL
      Q3TD99
      Conserved Domains (2) summary
      cd21464
      Location:38 → 60
      7tm_GPR137; TM helix 6 [structural motif]
      cl28897
      Location:30 → 143
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    7. NM_207220.3 → NP_997103.1  integral membrane protein GPR137 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC120557, BC048078, CX200961
      Consensus CDS
      CCDS29512.1
      UniProtKB/Swiss-Prot
      Q80UB6, Q80ZU9
      Related
      ENSMUSP00000130969.2, ENSMUST00000166115.9

    RNA

    1. NR_166767.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC120557
      Related
      ENSMUST00000235518.2

    2. NR_189038.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC120557

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      6915425..6919818 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161372.1 → XP_036017265.1  integral membrane protein GPR137 isoform X2

    2. XM_006526557.5 → XP_006526620.1  integral membrane protein GPR137 isoform X1

    RNA

    1. XR_001782554.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80ZU9.1 GenPept UniProtKB/Swiss-Prot:Q80ZU9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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