SCAR SCAR [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: SCARprovided by FlyBase
Official Full Name: SCARprovided by FlyBase
Primary source: FLYBASE:FBgn0041781
Locus tag: Dmel_CG4636
See related: AllianceGenome:FB:FBgn0041781
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BEST:SD02991; CG4636; D-SCAR; Dmel\CG4636; DmSCAR; Dscar; dWAVE; DWave; l(2)k03107; l(2)k13811; scar; Scar; scar/wave; SCAR/WAVE; wave; Wave; WAVE; WAVE/SCAR
Summary: Predicted to enable Arp2/3 complex binding activity and protein kinase A regulatory subunit binding activity. Involved in several processes, including actin cytoskeleton organization; generation of neurons; and positive regulation of cellular component organization. Located in several cellular components, including apical part of cell; basal part of cell; and nucleus. Part of SCAR complex. Is expressed in several structures, including adult head; indirect flight muscle cell; presumptive embryonic/larval central nervous system; and tract. Orthologous to several human genes including WASF3 (WASP family member 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 32C1-32C1; 2-44 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (10976772..10982395)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (10976772..10982395)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Robo recruitment of the Wave regulatory complex plays an essential and conserved role in midline repulsion.
Title: Robo recruitment of the Wave regulatory complex plays an essential and conserved role in midline repulsion.
Atxn7 amino terminus anchors Non-stop, a deubiquitinase, to the SAGA chromatin remodeling complex. There, Non-stop countered polyubiquitination and proteasomal degradation of Arp2/3 and WAVE regulatory complex (WRC) subunit SCAR.
Title: Ataxin-7 and Non-stop coordinate SCAR protein levels, subcellular localization, and actin cytoskeleton organization.
Using constitutively active Dia constructs, authors provide additional evidence that Dia functions upstream of SCAR activity to regulate actin dynamics at the fusion site and to localize the Abi-SCAR complex.
Title: Diaphanous regulates SCAR complex localization during Drosophila myoblast fusion.
Kette controls the ratio of the Arp2/3 activators Scar and WASp in fusion-competent myoblasts.
Title: Drosophila Kette coordinates myoblast junction dissolution and the ratio of Scar-to-WASp during myoblast fusion.
Lpd's Drosophila melanogaster orthologue Pico binds Scar, and both regulate collective epithelial border cell migration.
Title: Lamellipodin and the Scar/WAVE complex cooperate to promote cell migration in vivo.
study demonstrated SCAR is utilised by macrophages to drive their developmental and inflammatory migrations; in addition to driving formation of lamellipodia in macrophages, SCAR is required cell autonomously for the correct processing of phagocytosed apoptotic corpses by these professional phagocytes
Title: SCAR/WAVE-mediated processing of engulfed apoptotic corpses is essential for effective macrophage migration in Drosophila.
Study propose that Dock links cell adhesion in FCs and FCMs with either Scar- or Vrp1-WASp-dependent Arp2/3 activation.
Title: Dock mediates Scar- and WASp-dependent actin polymerization through interaction with cell adhesion molecules in founder cells and fusion-competent myoblasts.
expression of a membrane-tethered WAVE protein rescues the axonal projection defects of abi mutants in the absence of the other subunits of the WAVE complex.
Title: Membrane-targeted WAVE mediates photoreceptor axon targeting in the absence of the WAVE complex in Drosophila.
Wash, WASp, SCAR, and Whamy are dynamically expressed throughout oogenesis and embryogenesis.
Title: Developmental expression of Drosophila Wiskott-Aldrich Syndrome family proteins.
During the degradation of WAVE, Hem function is opposite to that of and downstream of Abl.
Title: The Hem protein mediates neuronal migration by inhibiting WAVE degradation and functions opposite of Abelson tyrosine kinase.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables Arp2/3 complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase A regulatory subunit binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Arp2/3 complex-mediated actin nucleation	IDA Inferred from Direct Assay more info	PubMed
involved_in actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in actin filament organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in actin filament-based process	TAS Traceable Author Statement more info	PubMed
involved_in axon extension involved in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axonal fasciculation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell adhesion mediated by integrin	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell projection assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cortical actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in female germline ring canal stabilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in myoblast fusion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in myoblast fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phagocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of Arp2/3 complex-mediated actin nucleation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of actin nucleation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of filopodium assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of filopodium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of lamellipodium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of actin nucleation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell shape	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of filopodium assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of SCAR complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SCAR complex	IDA Inferred from Direct Assay more info	PubMed
part_of SCAR complex	IPI Inferred from Physical Interaction more info	PubMed
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
located_in basal part of cell	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: SCAR

Names: CG4636-PA; CG4636-PB; CG4636-PC; CG4636-PD; CG4636-PE; CG4636-PF; SCAR-PA; SCAR-PB; SCAR-PC; SCAR-PD; SCAR-PE; SCAR-PF; WASP family verprolin-homologous protein; scar; suppressor of cAMP receptors; suppressor of cAR; suppressor of cyclic AMP receptor