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    CG8785 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36391, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG8785provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033760
    Locus tag
    Dmel_CG8785
    See related
    AllianceGenome:FB:FBgn0033760
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG8785
    Summary
    Predicted to enable L-amino acid transmembrane transporter activity. Predicted to be involved in amino acid transmembrane transport. Predicted to be active in vacuolar membrane. Is expressed in adult abdomen; adult head; adult thorax; embryonic midgut chamber; and embryonic/larval midgut. Human ortholog(s) of this gene implicated in iminoglycinuria. Orthologous to several human genes including SLC36A1 (solute carrier family 36 member 1); SLC36A2 (solute carrier family 36 member 2); and SLC36A3 (solute carrier family 36 member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG8785 in Genome Data Viewer
    Location:
    49B10-49B11; 2-67 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12640690..12648224, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8528195..8535729, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene spt4 Neighboring gene Mevalonate kinase Neighboring gene Imitation SWI Neighboring gene uncharacterized protein Neighboring gene Zinc transporter 49B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Comparative neuroanatomy and genomics of hugin and pheromone biosynthesis activating neuropeptide (PBAN). Bader R, et al. Fly (Austin), 2007 Jul-Aug. PMID 18820431
    2. Molecular Basis for Cephalic Mechanosensitivity of Drosophila Larvae. Zhang Z, et al. Neurosci Bull, 2020 Sep. PMID 32761438, Free PMC Article
    3. Differential amino acid transporter expression in adult Drosophila melanogaster tissues. Wright Y, et al. MicroPubl Biol, 2024. PMID 38481556, Free PMC Article
    4. The progesterone antagonist mifepristone/RU486 blocks the negative effect on life span caused by mating in female Drosophila. Landis GN, et al. Aging (Albany NY), 2015 Jan. PMID 25614682, Free PMC Article
    5. Dietary switch reveals fast coordinated gene expression changes in Drosophila melanogaster. Whitaker R, et al. Aging (Albany NY), 2014 May. PMID 24864304, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables L-amino acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables amino acid transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in amino acid transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in amino acid transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in vacuolar membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG8785-PA
    CG8785-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      12640690..12648224 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136960.3 → NP_610804.1  uncharacterized protein Dmel_CG8785, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610804.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K2W3
      Related
      FBpp0086994
      Conserved Domains (2) summary
      COG0814
      Location:60 → 457
      SdaC; Amino acid permease [Amino acid transport and metabolism]
      cl00456
      Location:62 → 463
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    2. NM_165932.2 → NP_725205.1  uncharacterized protein Dmel_CG8785, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725205.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K2W3
      Related
      FBpp0086995
      Conserved Domains (2) summary
      COG0814
      Location:60 → 457
      SdaC; Amino acid permease [Amino acid transport and metabolism]
      cl00456
      Location:62 → 463
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K2W3 Q7K2W3

    Gene LinkOut

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