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    Tpi Triose phosphate isomerase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43582, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Tpiprovided by FlyBase
    Official Full Name
    Triose phosphate isomeraseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0086355
    Locus tag
    Dmel_CG2171
    See related
    AllianceGenome:FB:FBgn0086355
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2171; Dmel\CG2171; ND14; sgk; tpi; TPI; TPIS; wstd
    Summary
    Enables protein homodimerization activity and triose-phosphate isomerase activity. Involved in several processes, including canonical glycolysis; determination of adult lifespan; and glucose homeostasis. Located in M band and Z disc. Is expressed in several structures, including adult head; adult heart; larval muscle system; muscle cell; and spermatozoon. Used to study neurodegenerative disease and triosephosphate isomerase deficiency. Human ortholog(s) of this gene implicated in carbohydrate metabolic disorder and triosephosphate isomerase deficiency. Orthologous to human TPI1 (triosephosphate isomerase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Tpi in Genome Data Viewer
    Location:
    99D8-99D8; 3-100 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (30132981..30134599, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (25958703..25960321, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Protein phosphatase 1c interacting protein 1 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR46082 Neighboring gene Adenosine receptor Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure and expression of the triose phosphate isomerase (Tpi) gene of Drosophila melanogaster. Shaw-Lee RL, et al. Mol Gen Genet, 1991 Nov. PMID 1720860
    2. Missense variant in TPI1 (Arg189Gln) causes neurologic deficits through structural changes in the triosephosphate isomerase catalytic site and reduced enzyme levels in vivo. Roland BP, et al. Biochim Biophys Acta Mol Basis Dis, 2019 Sep 1. PMID 31075491, Free PMC Article
    3. Triosephosphate isomerase I170V alters catalytic site, enhances stability and induces pathology in a Drosophila model of TPI deficiency. Roland BP, et al. Biochim Biophys Acta, 2015 Jan. PMID 25463631, Free PMC Article
    4. Evidence of a triosephosphate isomerase non-catalytic function crucial to behavior and longevity. Roland BP, et al. J Cell Sci, 2013 Jul 15. PMID 23641070, Free PMC Article
    5. Early mitochondrial dysfunction leads to altered redox chemistry underlying pathogenesis of TPI deficiency. Hrizo SL, et al. Neurobiol Dis, 2013 Jun. PMID 23318931, Free PMC Article

    See all (129) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. our findings are the first to identify, to our knowledge, a functional synaptic defect in TPI deficiency derived from molecular changes in the TPI dimer interface.
      Title: Structural and Genetic Studies Demonstrate Neurologic Dysfunction in Triosephosphate Isomerase Deficiency Is Associated with Impaired Synaptic Vesicle Dynamics.
    2. TPI sugarkill can be genetically complemented by TPI encoding a catalytically inactive enzyme.
      Title: Evidence of a triosephosphate isomerase non-catalytic function crucial to behavior and longevity.
    3. Mutation of wasted away, a recessive, hypomorphic mutation of triosephosphate isomerase (Tpi), highlights the essential protective role of triosephosphate isomerase.
      Title: wasted away, a Drosophila mutation in triosephosphate isomerase, causes paralysis, neurodegeneration, and early death.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables triose-phosphate isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables triose-phosphate isomerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables triose-phosphate isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables triose-phosphate isomerase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables triose-phosphate isomerase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in canonical glycolysis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in gluconeogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in gluconeogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glyceraldehyde-3-phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glyceraldehyde-3-phosphate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glyceraldehyde-3-phosphate metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in glycerol catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycolytic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycolytic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycolytic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nervous system process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to mechanical stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in M band IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Z disc IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    triose phosphate isomerase
    Names
    CG2171-PA
    CG2171-PB
    CG2171-PC
    Tpi-PA
    Tpi-PB
    Tpi-PC
    neurodegeneration 14
    sugarkill
    triosephosphate isomerase
    wasted away
    NP_788764.1
    NP_788765.1
    NP_788766.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      30132981..30134599 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_176587.2 → NP_788764.1  triose phosphate isomerase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788764.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P29613
      Related
      FBpp0084948
      Conserved Domains (1) summary
      PTZ00333
      Location:102 → 346
      PTZ00333; triosephosphate isomerase; Provisional

    2. NM_176588.2 → NP_788765.1  triose phosphate isomerase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788765.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O76995, P29613, Q0KHY9, Q6NLI5, Q7JNU4, Q8IMJ1, Q9TY56
      Related
      FBpp0084949
      Conserved Domains (1) summary
      PTZ00333
      Location:1 → 245
      PTZ00333; triosephosphate isomerase; Provisional

    3. NM_176589.2 → NP_788766.1  triose phosphate isomerase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788766.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O76995, P29613, Q0KHY9, Q6NLI5, Q7JNU4, Q8IMJ1, Q9TY56
      Related
      FBpp0084950
      Conserved Domains (1) summary
      PTZ00333
      Location:1 → 245
      PTZ00333; triosephosphate isomerase; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P29613.3 P29613

    Gene LinkOut

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