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    RpS19a Ribosomal protein S19a [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32635, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RpS19aprovided by FlyBase
    Official Full Name
    Ribosomal protein S19aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0010412
    Locus tag
    Dmel_CG4464
    See related
    AllianceGenome:FB:FBgn0010412
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GM26647; CG4464; Dmel\CG4464; Rp S19a; rpS19; RpS19; RPS19a; S19; S19a; S19e
    Summary
    A structural constituent of ribosome. Predicted to be involved in ribosomal small subunit assembly. Located in cytosolic ribosome. Is expressed in adult head. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia and Diamond-Blackfan anemia 1. Orthologous to human RPS19 (ribosomal protein S19). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See RpS19a in Genome Data Viewer
    Location:
    14F4-14F4; 1-54 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (16637894..16639249)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (16531927..16533282)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Rho kinase Neighboring gene antisense RNA:CR45001 Neighboring gene stem-bulge RNA 1 Neighboring gene Small nuclear ribonucleoprotein G Neighboring gene methuselah-like 1 Neighboring gene long non-coding RNA:CR46147

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila ribosomal protein S19 cDNA sequence. Baumgartner S, et al. Nucleic Acids Res, 1993 Aug 11. PMID 8367309, Free PMC Article
    2. The haplolethal gene wupA of Drosophila exhibits potential as a target for an X-poisoning gene drive. Lawler CD, et al. G3 (Bethesda), 2024 Apr 3. PMID 38306583, Free PMC Article
    3. Changes in the expression of genes involved in protein synthesis during Drosophila aging. Shikama N, et al. Gerontology, 1996. PMID 8796371
    4. Spliceosome malfunction causes neurodevelopmental disorders with overlapping features. Li D, et al. J Clin Invest, 2024 Jan 2. PMID 37962958, Free PMC Article
    5. Eukaryotic ribosomal protein RPS25 interacts with the conserved loop region in a dicistroviral intergenic internal ribosome entry site. Nishiyama T, et al. Nucleic Acids Res, 2007. PMID 17287295, Free PMC Article

    See all (66) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome HDA PubMed 
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of ribosome TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytoplasmic translation IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in cytoplasmic translation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in ribosomal small subunit assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosolic ribosome HDA PubMed 
    located_in cytosolic ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytosolic small ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic small ribosomal subunit TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ribosomal protein S19a
    Names
    CG4464-PA
    CG4464-PB
    CG4464-PC
    CG4464-PD
    CG4464-PE
    RpS19a-PA
    RpS19a-PB
    RpS19a-PC
    RpS19a-PD
    RpS19a-PE
    ribosomal protein S19

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      16637894..16639249
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298409.1 → NP_001285338.1  ribosomal protein S19a, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285338.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V4N1, B7Z0Y8, P39018, Q9VXE1
      UniProtKB/TrEMBL
      E2QD65
      Conserved Domains (1) summary
      pfam01090
      Location:5 → 139
      Ribosomal_S19e; Ribosomal protein S19e

    2. NM_167527.3 → NP_727993.1  ribosomal protein S19a, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727993.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V4N1, B7Z0Y8, P39018, Q9VXE1
      UniProtKB/TrEMBL
      E2QD65
      Related
      FBpp0074088
      Conserved Domains (1) summary
      pfam01090
      Location:5 → 139
      Ribosomal_S19e; Ribosomal protein S19e

    3. NM_167526.3 → NP_727992.1  ribosomal protein S19a, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727992.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V4N1, B7Z0Y8, P39018, Q9VXE1
      UniProtKB/TrEMBL
      E2QD65
      Related
      FBpp0074087
      Conserved Domains (1) summary
      pfam01090
      Location:5 → 139
      Ribosomal_S19e; Ribosomal protein S19e

    4. NM_078652.4 → NP_523376.1  ribosomal protein S19a, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523376.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V4N1, B7Z0Y8, P39018, Q9VXE1
      UniProtKB/TrEMBL
      E2QD65
      Related
      FBpp0074086
      Conserved Domains (1) summary
      pfam01090
      Location:5 → 139
      Ribosomal_S19e; Ribosomal protein S19e

    5. NM_001298410.1 → NP_001285339.1  ribosomal protein S19a, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285339.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V4N1, B7Z0Y8, P39018, Q9VXE1
      UniProtKB/TrEMBL
      E2QD65
      Conserved Domains (1) summary
      pfam01090
      Location:5 → 139
      Ribosomal_S19e; Ribosomal protein S19e
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E2QD65 E2QD65
    P39018.3 P39018

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