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    dare defective in the avoidance of repellents [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36203, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dareprovided by FlyBase
    Official Full Name
    defective in the avoidance of repellentsprovided by FlyBase
    Primary source
    FLYBASE:FBgn0015582
    Locus tag
    Dmel_CG12390
    See related
    AllianceGenome:FB:FBgn0015582
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AR; CG12390; Dare; Dmel\CG12390; W8
    Summary
    Predicted to enable NADPH-adrenodoxin reductase activity. Involved in several processes, including olfactory behavior; pupariation; and steroid biosynthetic process. Is active in mitochondrion. Is expressed in several structures, including adult head; nurse cell; ovary; prothoracic gland; and ring gland. Orthologous to human FDXR (ferredoxin reductase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See dare in Genome Data Viewer
    Location:
    47F1-47F1; 2-64 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (11290994..11293174, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (7178499..7180679, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene F-box and leucine-rich repeat protein 6 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Odorant-binding protein 47b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The dare gene: steroid hormone production, olfactory behavior, and neural degeneration in Drosophila. Freeman MR, et al. Development, 1999 Oct. PMID 10498693
    2. Evidence for activation of nitenpyram by a mitochondrial cytochrome P450 in Drosophila melanogaster. Harrop TW, et al. Pest Manag Sci, 2018 Jul. PMID 29316188
    3. Ecdysone response genes govern egg chamber development during mid-oogenesis in Drosophila. Buszczak M, et al. Development, 1999 Oct. PMID 10498692
    4. molting defective is required for ecdysone biosynthesis. Neubueser D, et al. Dev Biol, 2005 Apr 15. PMID 15882578
    5. Steroid regulation of postembryonic development and reproduction in Drosophila. Kozlova T, et al. Trends Endocrinol Metab, 2000 Sep. PMID 10920384

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables NADPH-adrenodoxin reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NADPH-adrenodoxin reductase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in NADPH oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in metamorphosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in molting cycle, chitin-based cuticle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in olfactory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein maturation by iron-sulfur cluster transfer NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in pupariation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in steroid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in steroid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in steroid biosynthetic process IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrial matrix NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    defective in the avoidance of repellents
    Names
    ADXRDTASE
    CG12390-PA
    adrenodoxin reductase
    dare-PA
    NP_477150.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      11290994..11293174 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057802.6 → NP_477150.1  defective in the avoidance of repellents [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477150.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V3T9
      UniProtKB/TrEMBL
      C4IY01, Q8IGW0
      Related
      FBpp0087272
      Conserved Domains (2) summary
      PLN02852
      Location:10 → 465
      PLN02852; ferredoxin-NADP+ reductase
      pfam13450
      Location:34 → 98
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IGW0 Q8IGW0
    Q95RP7 Q95RP7
    Q9V3T9.1 Q9V3T9

    Gene LinkOut

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