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    Prosalpha3 Proteasome alpha3 subunit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37378, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Prosalpha3provided by FlyBase
    Official Full Name
    Proteasome alpha3 subunitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0261394
    Locus tag
    Dmel_CG9327
    See related
    AllianceGenome:FB:FBgn0261394
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    alpha-3; Alpha-3; alpha3; alpha3_dm; CG9327; Dmel\CG9327; PROS-29; Pros-alpha3; Pros20S-alpha3; pros29; Pros29; prosalpha3; PSB3_DROME
    Summary
    Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Located in cytoplasm and nucleus. Part of proteasome core complex. Is expressed in several structures, including adult head; adult heart; embryonic/larval salivary gland; germline cell; and gonad. Orthologous to human PSMA4 (proteasome 20S subunit alpha 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Prosalpha3 in Genome Data Viewer
    Location:
    57B5-57B5; 2-92 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (20994900..20996118)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (16882405..16883623)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene dim gamma-tubulin 3 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila PROS-29 gene is a new member of the PROS-gene family. Haass C, et al. Nucleic Acids Res, 1990 Jul 11. PMID 2374736, Free PMC Article
    2. Purification and characterization of a multiprotein component of the Drosophila 26 S (1500 kDa) proteolytic complex. Udvardy A. J Biol Chem, 1993 Apr 25. PMID 8386175
    3. Caspase-dependent inactivation of proteasome function during programmed cell death in Drosophila and man. Adrain C, et al. J Biol Chem, 2004 Aug 27. PMID 15210720
    4. Molecular cloning of the Drosophila melanogaster gene alpha5_dm encoding a 20S proteasome alpha-type subunit. Zaiss D, et al. Gene, 1997 Nov 12. PMID 9409776
    5. The DUG gene of Drosophila melanogaster encodes a structural and functional homolog of the S. cerevisiae SUG1 predicted ATPase associated with the 26S proteasome. Mounkes LC, et al. Gene, 1998 Jan 12. PMID 9469929

    See all (74) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables peptidase activity IKR
    Inferred from Key Residues
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proteasome complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proteasome core complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proteasome core complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proteasome core complex, alpha-subunit complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proteasome core complex, alpha-subunit complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proteasome core complex, alpha-subunit complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    proteasome alpha3 subunit
    Names
    20s proteasome
    CG9327-PA
    Prosalpha3-PA
    alpha-subunit of 20S proteasome
    alpha3
    proteasome 20S alpha3 subunit
    proteasome 29kD subunit
    proteasome subunit alpha-type 4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      20994900..20996118
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057343.5 → NP_476691.1  proteasome alpha3 subunit [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476691.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P18053, Q9W2N9
      Related
      FBpp0071451
      Conserved Domains (2) summary
      PTZ00246
      Location:1 → 245
      PTZ00246; proteasome subunit alpha; Provisional
      cd03752
      Location:3 → 219
      proteasome_alpha_type_4; proteasome_alpha_type_4. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P18053.2 P18053

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