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    Prx1 Peroxiredoxin 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39658, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Prx1provided by FlyBase
    Official Full Name
    Peroxiredoxin 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0036490
    Locus tag
    Dmel_CG6888
    See related
    AllianceGenome:FB:FBgn0036490
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    6888; BcDNA:AT16346; CG6888; Dmel\CG6888; dPrx1
    Summary
    Enables peroxiredoxin activity. Predicted to be involved in cell redox homeostasis; hydrogen peroxide catabolic process; and removal of superoxide radicals. Predicted to be located in cytoplasm and extracellular exosome. Predicted to be active in cytosol. Is expressed in adult head and spermatozoon. Human ortholog(s) of this gene implicated in methylmalonic aciduria and homocystinuria type cblC. Orthologous to human PRDX1 (peroxiredoxin 1) and PRDX2 (peroxiredoxin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Prx1 in Genome Data Viewer
    Location:
    71B8-71B8; 3-42 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (15207844..15208586)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (15200944..15201686)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44562 Neighboring gene tollo Neighboring gene Bestrophin 4 Neighboring gene Bestrophin 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Hyperoxidation of Peroxiredoxins and Effects on Physiology of Drosophila. McGinnis A, et al. Antioxidants (Basel), 2021 Apr 15. PMID 33920774, Free PMC Article
    2. Antioxidant proteins TSA and PAG interact synergistically with Presenilin to modulate Notch signaling in Drosophila. Wangler MF, et al. Protein Cell, 2011 Jul. PMID 21822800, Free PMC Article
    3. Peroxiredoxins are conserved markers of circadian rhythms. Edgar RS, et al. Nature, 2012 May 16. PMID 22622569, Free PMC Article
    4. Genome wide analysis of common and specific stress responses in adult drosophila melanogaster. Girardot F, et al. BMC Genomics, 2004 Sep 30. PMID 15458575, Free PMC Article
    5. Analyses of nuclearly encoded mitochondrial genes suggest gene duplication as a mechanism for resolving intralocus sexually antagonistic conflict in Drosophila. Gallach M, et al. Genome Biol Evol, 2010. PMID 21037198, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables peroxiredoxin activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peroxiredoxin activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peroxiredoxin activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables thioredoxin peroxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell redox homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in hydrogen peroxide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in hydrogen peroxide catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in removal of superoxide radicals IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to oxidative stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular exosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    peroxiredoxin 1
    Names
    CG6888-PA
    Prx1-PA
    NP_648759.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      15207844..15208586
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140502.3 → NP_648759.1  peroxiredoxin 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648759.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VUM4
      Related
      FBpp0075397
      Conserved Domains (2) summary
      COG0450
      Location:3 → 194
      AhpC; Alkyl hydroperoxide reductase subunit AhpC (peroxiredoxin) [Defense mechanisms]
      cd03015
      Location:6 → 177
      PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VUM4 Q9VUM4

    Gene LinkOut

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