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    Fntb Farnesyl transferase beta subunit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41989, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fntbprovided by FlyBase
    Official Full Name
    Farnesyl transferase beta subunitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038424
    Locus tag
    Dmel_CG17565
    See related
    AllianceGenome:FB:FBgn0038424
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG17565; Dmel\CG17565; FNTB
    Summary
    Predicted to enable protein prenyltransferase activity. Predicted to contribute to protein farnesyltransferase activity. Predicted to be part of protein farnesyltransferase complex. Is expressed in organism. Human ortholog(s) of this gene implicated in anxiety disorder. Orthologous to human CHURC1-FNTB (CHURC1-FNTB readthrough) and FNTB (farnesyltransferase, CAAX box, subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Fntb in Genome Data Viewer
    Location:
    89B16-89B16; 3-58 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (16432998..16434740)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (12258720..12260462)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45631 Neighboring gene transfer RNA:Threonine-AGT 1-4 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein S33 Neighboring gene endosomal maturation defective

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The structure and population genetics of the breakpoints associated with the cosmopolitan chromosomal inversion In(3R)Payne in Drosophila melanogaster. Matzkin LM, et al. Genetics, 2005 Jul. PMID 15781702, Free PMC Article
    2. Strabismus promotes recruitment and degradation of farnesylated prickle in Drosophila melanogaster planar polarity specification. Strutt H, et al. PLoS Genet, 2013. PMID 23874239, Free PMC Article
    3. Isoprenoids control germ cell migration downstream of HMGCoA reductase. Santos AC, et al. Dev Cell, 2004 Feb. PMID 14960281
    4. RAS-MAPK-MSK1 pathway modulates ataxin 1 protein levels and toxicity in SCA1. Park J, et al. Nature, 2013 Jun 20. PMID 23719381, Free PMC Article
    5. Genetic Modifiers of Neurodegeneration in a Drosophila Model of Parkinson's Disease. Lavoy S, et al. Genetics, 2018 Aug. PMID 29907646, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    contributes_to protein farnesyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein prenyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein farnesylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of protein farnesyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein farnesyltransferase complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    farnesyl transferase beta subunit
    Names
    CG17565-PA
    Fntb-PA
    farnesyl transferase beta

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      16432998..16434740
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142283.4 → NP_650540.1  farnesyl transferase beta subunit [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650540.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VEV7
      Related
      FBpp0082737
      Conserved Domains (2) summary
      PLN02710
      Location:27 → 403
      PLN02710; farnesyltranstransferase subunit beta
      cd02893
      Location:62 → 360
      FTase; Protein farnesyltransferase (FTase)_like proteins containing the protein prenyltransferase (PTase) domain, beta subunit (alpha 6 - alpha 6 barrel fold). FTases are a subgroup of PTase family of lipid-modifying enzymes. PTases catalyze the ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VEV7 Q9VEV7

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