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    Nle Notchless [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33234, updated on 27-Dec-2024

    Summary

    Official Symbol
    Nleprovided by FlyBase
    Official Full Name
    Notchlessprovided by FlyBase
    Primary source
    FLYBASE:FBgn0021874
    Locus tag
    Dmel_CG2863
    See related
    AllianceGenome:FB:FBgn0021874
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0026364; CG2863; Dmel\CG2863; l(2)k13714; nle
    Summary
    Enables Notch binding activity. Involved in negative regulation of Notch signaling pathway and positive regulation of Notch signaling pathway. Predicted to be active in nucleolus. Is expressed in several structures, including Malpighian tubule primordium; anal pad primordium; embryonic/larval midgut primordium; gut section; and larval somatic muscle cell. Orthologous to human NLE1 (notchless homolog 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Nle in Genome Data Viewer
    Location:
    21E2-21E2; 2-1.5 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (566366..568121, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (566366..568121, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene reduced mechanoreceptor potential A Neighboring gene uncharacterized nascent polypeptide-associated complex beta subunit Neighboring gene Translocator protein Neighboring gene uncharacterized protein Neighboring gene Splicing factor 3b subunit 1 Neighboring gene Inositol phosphate kinase 2

    Genomic regions, transcripts, and products

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by FlyBase

    Component Evidence Code Pubs
    is_active_in nucleolus  

    General protein information

    Preferred Names
    notchless
    Names
    CG2863-PA
    Nle-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      566366..568121 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057946.4 → NP_477294.2  notchless [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477294.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O96995, Q8T4A2, Q9VPR4
      Related
      FBpp0077735
      Conserved Domains (5) summary
      COG2319
      Location:112 → 486
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:153 → 487
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam00400
      Location:110 → 147
      WD40; WD domain, G-beta repeat
      pfam08154
      Location:22 → 82
      NLE; NLE (NUC135) domain
      sd00039
      Location:164 → 202
      7WD40; WD40 repeat [structural motif]
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