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    Rrp47 Ribosomal RNA processing 47 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32558, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rrp47provided by FlyBase
    Official Full Name
    Ribosomal RNA processing 47provided by FlyBase
    Primary source
    FLYBASE:FBgn0030711
    Locus tag
    Dmel_CG8928
    See related
    AllianceGenome:FB:FBgn0030711
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8928; Dmel\CG8928; dRrp47; lincRNA.1007
    Summary
    Predicted to enable DNA binding activity and RNA binding activity. Involved in regulation of gene expression. Part of exosome (RNase complex). Orthologous to human C1D (C1D nuclear receptor corepressor). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Rrp47 in Genome Data Viewer
    Location:
    14A1-14A1; 1-52 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (15944897..15946249)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (15838930..15840282)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Stromal interaction molecule Neighboring gene uncharacterized protein Neighboring gene mind-meld Neighboring gene mir-927 stem loop Neighboring gene long non-coding RNA:CR45527

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila melanogaster Dis3 N-terminal domains are required for ribonuclease activities, nuclear localization and exosome interactions. Mamolen M, et al. Nucleic Acids Res, 2010 Sep. PMID 20421210, Free PMC Article
    2. Genome-wide analysis reveals distinct substrate specificities of Rrp6, Dis3, and core exosome subunits. Kiss DL, et al. RNA, 2010 Apr. PMID 20185544, Free PMC Article
    3. An efficient protein complex purification method for functional proteomics in higher eukaryotes. Forler D, et al. Nat Biotechnol, 2003 Jan. PMID 12483225
    4. Interdependent nucleocytoplasmic trafficking and interactions of Dis3 with Rrp6, the core exosome and importin-alpha3. Graham AC, et al. Traffic, 2009 May. PMID 19220816, Free PMC Article
    5. Adaptation of gene loci to heterochromatin in the course of Drosophila evolution is associated with insulator proteins. Funikov SY, et al. Sci Rep, 2020 Jul 17. PMID 32681087, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in maturation of 5.8S rRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of exosome (RNase complex) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of exosome (RNase complex) IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ribosomal RNA processing 47
    Names
    CG8928-PA
    CG8928-PB
    Rrp47-PA
    Rrp47-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      15944897..15946249
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298381.1 → NP_001285310.1  ribosomal RNA processing 47, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285310.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VXL4
      Conserved Domains (1) summary
      pfam04000
      Location:32 → 105
      Sas10_Utp3; Sas10/Utp3/C1D family

    2. NM_132864.2 → NP_573092.1  ribosomal RNA processing 47, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573092.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VXL4
      Related
      FBpp0073937
      Conserved Domains (1) summary
      pfam04000
      Location:32 → 105
      Sas10_Utp3; Sas10/Utp3/C1D family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VXL4 Q9VXL4

    Gene LinkOut

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