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    Myo28B1 Myosin 28B1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 53515, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Myo28B1provided by FlyBase
    Official Full Name
    Myosin 28B1provided by FlyBase
    Primary source
    FLYBASE:FBgn0040299
    Locus tag
    Dmel_CG6976
    See related
    AllianceGenome:FB:FBgn0040299
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    28B; CG6976; Dmel\CG6976; DmVIIB; myo 28B1; Myo18; myo28B; Myo28B; VIIb 28B
    Summary
    Enables microfilament motor activity. Predicted to be involved in actin filament organization and sensory organ development. Part of myosin complex. Is expressed in adult head. Orthologous to human MYO7B (myosin VIIB). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Myo28B1 in Genome Data Viewer
    Location:
    28C1-28C1; 2-28 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (7666047..7689459)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (7666047..7689459)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44799 Neighboring gene long non-coding RNA:CR44800 Neighboring gene Slowpoke binding protein Neighboring gene long non-coding RNA:CR44148 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Thioester-containing protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Myosin VIIB from Drosophila is a high duty ratio motor. Yang Y, et al. J Biol Chem, 2005 Sep 16. PMID 16055438
    2. Regulation of nuclear morphology by actomyosin components and cell geometry. Ramdas NM, et al. Annu Int Conf IEEE Eng Med Biol Soc, 2015. PMID 26736269
    3. A millennial myosin census. Berg JS, et al. Mol Biol Cell, 2001 Apr. PMID 11294886, Free PMC Article
    4. An ongoing role for structural sarcomeric components in maintaining Drosophila melanogaster muscle function and structure. Perkins AD, et al. PLoS One, 2014. PMID 24915196, Free PMC Article
    5. Identification and phylogenetic analysis of Drosophila melanogaster myosins. Tzolovsky G, et al. Mol Biol Evol, 2002 Jul. PMID 12082124

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Drosophila myosin VIIB is a high duty ratio motor
      Title: Myosin VIIB from Drosophila is a high duty ratio motor.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cytoskeletal motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microfilament motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microfilament motor activity IC
    Inferred by Curator
    more info
    		 PubMed 
    enables microfilament motor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament-based movement IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in sensory organ development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microvillus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of myosin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of myosin complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    myosin 28B1
    Names
    CG6976-PA
    CG6976-PB
    CG6976-PC
    CG6976-PD
    Myo28B1-PA
    Myo28B1-PB
    Myo28B1-PC
    Myo28B1-PD
    myosin VII
    myosin VII (28B)
    myosin VII 28B1-B4
    myosin VIIB
    NP_652630.2
    NP_723294.1
    NP_723295.2
    NP_723296.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      7666047..7689459
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_164758.2 → NP_723294.1  myosin 28B1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723294.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IPH8, Q9NH54
      Related
      FBpp0079097
      Conserved Domains (12) summary
      smart00015
      Location:765 → 785
      IQ; Calmodulin-binding motif
      smart00139
      Location:1674 → 1819
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00242
      Location:62 → 737
      MYSc; Myosin. Large ATPases
      smart00295
      Location:1827 → 2032
      B41; Band 4.1 homologues
      cd13199
      Location:2028 → 2121
      FERM_C2_MyoVII; FERM domain C-lobe, repeat 2, of Myosin VII (MyoVII, Myo7)
      cd14473
      Location:1342 → 1429
      FERM_B-lobe; FERM domain B-lobe
      cd01381
      Location:81 → 726
      MYSc_Myo7; class VII myosin, motor domain
      pfam00373
      Location:1936 → 2032
      FERM_M; FERM central domain
      pfam09379
      Location:1248 → 1288
      FERM_N; FERM N-terminal domain
      pfam14265
      Location:827 → 887
      DUF4355; Domain of unknown function (DUF4355)
      cl02480
      Location:1031 → 1239
      MyTH4; MyTH4 domain
      cl17171
      Location:1454 → 1547
      PH-like; Pleckstrin homology-like domain

    2. NM_164759.3 → NP_723295.2  myosin 28B1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723295.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7YU72, Q8IPH7
      Conserved Domains (3) summary
      smart00242
      Location:62 → 737
      MYSc; Myosin. Large ATPases
      cd01381
      Location:81 → 726
      MYSc_Myo7; class VII myosin, motor domain
      pfam14265
      Location:827 → 887
      DUF4355; Domain of unknown function (DUF4355)

    3. NM_144373.4 → NP_652630.2  myosin 28B1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_652630.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9NH54, Q9VLZ3
      Related
      FBpp0079099
      Conserved Domains (12) summary
      smart00015
      Location:764 → 784
      IQ; Calmodulin-binding motif
      smart00139
      Location:1673 → 1818
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00242
      Location:61 → 736
      MYSc; Myosin. Large ATPases
      smart00295
      Location:1826 → 2031
      B41; Band 4.1 homologues
      cd13199
      Location:2027 → 2120
      FERM_C2_MyoVII; FERM domain C-lobe, repeat 2, of Myosin VII (MyoVII, Myo7)
      cd14473
      Location:1341 → 1428
      FERM_B-lobe; FERM domain B-lobe
      cd01381
      Location:80 → 725
      MYSc_Myo7; class VII myosin, motor domain
      pfam00373
      Location:1935 → 2031
      FERM_M; FERM central domain
      pfam09379
      Location:1247 → 1287
      FERM_N; FERM N-terminal domain
      pfam14265
      Location:826 → 886
      DUF4355; Domain of unknown function (DUF4355)
      cl02480
      Location:1030 → 1238
      MyTH4; MyTH4 domain
      cl17171
      Location:1453 → 1546
      PH-like; Pleckstrin homology-like domain

    4. NM_164760.4 → NP_723296.2  myosin 28B1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723296.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5U1A3, Q8IPH6
      Conserved Domains (3) summary
      smart00242
      Location:61 → 736
      MYSc; Myosin. Large ATPases
      cd01381
      Location:80 → 725
      MYSc_Myo7; class VII myosin, motor domain
      pfam14265
      Location:826 → 886
      DUF4355; Domain of unknown function (DUF4355)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7YU72 Q7YU72
    Q8IPH6 Q8IPH6
    Q8IPH7 Q8IPH7
    Q8IPH8 Q8IPH8
    Q9NH54 Q9NH54
    Q9VLZ3 Q9VLZ3

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