Hsepi Heparan sulfate C5-epimerase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Hsepiprovided by FlyBase
Official Full Name: Heparan sulfate C5-epimeraseprovided by FlyBase
Primary source: FLYBASE:FBgn0033087
Locus tag: Dmel_CG3194
See related: AllianceGenome:FB:FBgn0033087
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG3194; Dmel\CG3194
Summary: Predicted to enable heparosan-N-sulfate-glucuronate 5-epimerase activity. Involved in heparan sulfate proteoglycan biosynthetic process. Predicted to be active in Golgi apparatus. Is expressed in adult head; epithelial furrow; imaginal disc; and nurse cell. Human ortholog(s) of this gene implicated in cerebrovascular disease and hypertension. Orthologous to human GLCE (glucuronic acid epimerase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (6670154..6673372, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (2557659..2560877, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

This result suggests that the increase in 6-O-sulfation in Hsepi mutants is critical for the rescue of FGF signaling
Title: Analysis of Drosophila glucuronyl C5-epimerase: implications for developmental roles of heparan sulfate sulfation compensation and 2-O-sulfated glucuronic acid.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables heparosan-N-sulfate-glucuronate 5-epimerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables heparosan-N-sulfate-glucuronate 5-epimerase activity	IEA Inferred from Electronic Annotation more info
enables heparosan-N-sulfate-glucuronate 5-epimerase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in heparan sulfate proteoglycan biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in heparan sulfate proteoglycan biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in heparan sulfate proteoglycan biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info

Names: C5-epimerase; CG3194-PA; CG3194-PB; Hsepi-PA; Hsepi-PB; heparan sulfate glucuronyl C5-epimerase

NP_001163062.1

NP_610249.2

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The following sections contain reference sequences that belong to a specific genome build. Explain