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    RhoGEF4 Rho guanine nucleotide exchange factor 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38806, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RhoGEF4provided by FlyBase
    Official Full Name
    Rho guanine nucleotide exchange factor 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0035761
    Locus tag
    Dmel_CG8606
    See related
    AllianceGenome:FB:FBgn0035761
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8606; Dmel\CG8606; DRhoGEF4; RhoGEF
    Summary
    Enables guanyl-nucleotide exchange factor activity. Involved in cleavage furrow ingression; positive regulation of Rho protein signal transduction; and positive regulation of stress fiber assembly. Located in midbody; mitotic actomyosin contractile ring; and nucleus. Is expressed in several structures, including CNS glial cell; antennal anlage; antennal primordium; ganglia; and head epidermis primordium. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 4H. Orthologous to human FGD4 (FYVE, RhoGEF and PH domain containing 4) and ARHGEF39 (Rho guanine nucleotide exchange factor 39). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See RhoGEF4 in Genome Data Viewer
    Location:
    65F4-65F4; 3-20 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (7321099..7323411, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (7314199..7316511, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR43470 Neighboring gene uncharacterized protein Neighboring gene unc-13-4A Neighboring gene uncharacterized protein Neighboring gene RAD50 interactor 1 Neighboring gene minerva

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Formin-mediated actin polymerization cooperates with Mushroom body defect (Mud)-Dynein during Frizzled-Dishevelled spindle orientation. Johnston CA, et al. J Cell Sci, 2013 Oct 1. PMID 23868974, Free PMC Article
    2. Drosophila RhoGEF4 encodes a novel RhoA-specific guanine exchange factor that is highly expressed in the embryonic central nervous system. Nahm M, et al. Gene, 2006 Dec 15. PMID 17011730
    3. Modular activation of Rho1 by GPCR signalling imparts polarized myosin II activation during morphogenesis. Kerridge S, et al. Nat Cell Biol, 2016 Mar. PMID 26780298
    4. Cross-talk between Rho and Rac GTPases drives deterministic exploration of cellular shape space and morphological heterogeneity. Sailem H, et al. Open Biol, 2014 Jan 22. PMID 24451547, Free PMC Article
    5. Gene expression profiling identifies the zinc-finger protein Charlatan as a regulator of intestinal stem cells in Drosophila. Amcheslavsky A, et al. Development, 2014 Jul. PMID 24961799, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Taken together, these findings suggest that RhoGEF4 may participate in cytoskeleton-related cellular events by specifically activating RhoA in neuronal morphogenesis.
      Title: Drosophila RhoGEF4 encodes a novel RhoA-specific guanine exchange factor that is highly expressed in the embryonic central nervous system.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cleavage furrow ingression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of Rho protein signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of stress fiber assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in midbody IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitotic actomyosin contractile ring IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Rho guanine nucleotide exchange factor 4
    Names
    CG8606-PA
    CG8606-PB
    RhoGEF4-PA
    RhoGEF4-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      7321099..7323411 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139844.3 → NP_648101.1  Rho guanine nucleotide exchange factor 4, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648101.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86NY7, Q9VS45
      Related
      FBpp0076595
      Conserved Domains (3) summary
      pfam00169
      Location:277 → 374
      PH; PH domain
      pfam00621
      Location:74 → 244
      RhoGEF; RhoGEF domain
      cl17171
      Location:269 → 311
      PH-like; Pleckstrin homology-like domain

    2. NM_168199.2 → NP_729232.1  Rho guanine nucleotide exchange factor 4, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729232.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86NY7, Q8IQ85
      Related
      FBpp0076596
      Conserved Domains (3) summary
      pfam00169
      Location:230 → 327
      PH; PH domain
      pfam00621
      Location:27 → 197
      RhoGEF; RhoGEF domain
      cl17171
      Location:222 → 264
      PH-like; Pleckstrin homology-like domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86NY7 Q86NY7
    Q8IQ85 Q8IQ85
    Q9VS45 Q9VS45

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