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    CG12477 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40040, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG12477provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036809
    Locus tag
    Dmel_CG12477
    See related
    AllianceGenome:FB:FBgn0036809
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG12477
    Summary
    Predicted to enable RNA binding activity; ubiquitin protein ligase activity; and zinc ion binding activity. Predicted to be involved in protein polyubiquitination. Predicted to be part of ribonucleoprotein complex. Is expressed in organism. Human ortholog(s) of this gene implicated in central precocious puberty 2. Orthologous to several human genes including MKRN1 (makorin ring finger protein 1); MKRN2 (makorin ring finger protein 2); and MKRN3 (makorin ring finger protein 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG12477 in Genome Data Viewer
    Location:
    75D7-75D7; 3-45 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (18721893..18723272, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (18714993..18716372, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Dicarboxylate carrier 4 Neighboring gene long non-coding RNA:CR44674 Neighboring gene long non-coding RNA:CR43985 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila slamdance gene: a mutation in an aminopeptidase can cause seizure, paralysis and neuronal failure. Zhang H, et al. Genetics, 2002 Nov. PMID 12454073, Free PMC Article
    2. Makorin 1 Regulates Developmental Timing in Drosophila. Tran HT, et al. Mol Cells, 2018 Dec 31. PMID 30396233, Free PMC Article
    3. Transient chromatin decompaction at the start of D. melanogaster male embryonic germline development. Li YR, et al. Life Sci Alliance, 2024 Oct. PMID 38991729, Free PMC Article
    4. Makorin 1 controls embryonic patterning by alleviating Bruno1-mediated repression of oskar translation. Dold A, et al. PLoS Genet, 2020 Jan. PMID 31978041, Free PMC Article
    5. Quantitative genetic analysis of sleep in Drosophila melanogaster. Harbison ST, et al. Genetics, 2008 Apr. PMID 18430954, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables zinc ion binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein polyubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein polyubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of ribonucleoprotein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG12477-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      18721893..18723272 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140798.2 → NP_649055.1  uncharacterized protein Dmel_CG12477 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649055.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VVS2
      Related
      FBpp0074856
      Conserved Domains (1) summary
      cd00162
      Location:99 → 153
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VVS2 Q9VVS2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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