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    pds5 precocious dissociation of sisters 5 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36286, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pds5provided by FlyBase
    Official Full Name
    precocious dissociation of sisters 5provided by FlyBase
    Primary source
    FLYBASE:FBgn0260012
    Locus tag
    Dmel_CG17509
    See related
    AllianceGenome:FB:FBgn0260012
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.183; CG17509; Dmel\CG17509; dPds5; l(2)k13312; Pds5; PDS5
    Summary
    Enables cohesin unloader activity. Involved in chromosome segregation; mitotic sister chromatid cohesion; and oocyte karyosome formation. Located in nucleus and polytene chromosome. Orthologous to human PDS5A (PDS5 cohesin associated factor A) and PDS5B (PDS5 cohesin associated factor B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See pds5 in Genome Data Viewer
    Location:
    48D7-48D8; 2-65 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12027985..12033725)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (7915490..7921230)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene off-track2 Neighboring gene Metallophosphoesterase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene upstream of RpIII128

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Wapl antagonizes cohesin binding and promotes Polycomb-group silencing in Drosophila. Cunningham MD, et al. Development, 2012 Nov. PMID 23034634, Free PMC Article
    2. Interphase cohesin regulation ensures mitotic fidelity after genome reduplication. Stormo BM, et al. Mol Biol Cell, 2019 Jan 15. PMID 30462577, Free PMC Article
    3. Cohesin, gene expression and development: lessons from Drosophila. Dorsett D. Chromosome Res, 2009. PMID 19308700, Free PMC Article
    4. The Drosophila cohesin subunit Rad21 is a trithorax group (trxG) protein. Hallson G, et al. Proc Natl Acad Sci U S A, 2008 Aug 26. PMID 18713858, Free PMC Article
    5. Effects of sister chromatid cohesion proteins on cut gene expression during wing development in Drosophila. Dorsett D, et al. Development, 2005 Nov. PMID 16207752, Free PMC Article

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Haspin kinase modulates nuclear architecture and Polycomb-dependent gene silencing.
      Title: Haspin kinase modulates nuclear architecture and Polycomb-dependent gene silencing.
    2. persistent meiotic DNA double-strand breaks might correspond to crossovers, which are mobilized to the nuclear envelope for their repair; Brca2-Pds5 complexes may be key mediators of this process.
      Title: Brca2-Pds5 complexes mobilize persistent meiotic recombination sites to the nuclear envelope.
    3. Nipped-B and Pds5 regulate transcription by controlling how much cohesin binds DNA in the stable mode, and not binding affinity.
      Title: Dosage-sensitive regulation of cohesin chromosome binding and dynamics by Nipped-B, Pds5, and Wapl.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cohesin unloader activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic sister chromatid cohesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic sister chromatid cohesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic sister chromatid cohesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oocyte karyosome formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sister chromatid cohesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in polytene chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    precocious dissociation of sisters 5
    Names
    CG17509-PA
    CG17509-PB
    cohiba
    lethal (2) k13312
    pds5-PA
    pds5-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      12027985..12033725
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259342.2 → NP_001246271.1  precocious dissociation of sisters 5, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246271.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z8S6

    2. NM_136875.4 → NP_610719.1  precocious dissociation of sisters 5, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610719.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z8S6
      Related
      FBpp0087082
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z8S6 A1Z8S6
    Q95U25 Q95U25

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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