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    LAMA4 laminin subunit alpha 4 [ Bos taurus (domestic cattle) ]

    Gene ID: 529670, updated on 30-Jan-2025

    Summary

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    Official Symbol
    LAMA4provided by VGNC
    Official Full Name
    laminin subunit alpha 4provided by VGNC
    Primary source
    VGNC:VGNC:52792
    See related
    BGD:BT12452; EnsemblRapid:ENSBTAG00070005172
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See LAMA4 in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    40
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 9 NC_037336.1 (38176073..38331079)

    Chromosome 9 - NC_037336.1Genomic Context describing neighboring genes Neighboring gene CWF19-like protein 1 Neighboring gene nucleophosmin-like Neighboring gene family with sequence similarity 229 member B Neighboring gene tubulin epsilon 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037336.1 Chromosome 9 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables signaling receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of embryonic development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    laminin subunit alpha-4
    Names
    laminin, alpha 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001205965.1 → NP_001192894.1  laminin subunit alpha-4 precursor

      Status: PROVISIONAL

      Source sequence(s)
      NKLS02000009
      UniProtKB/TrEMBL
      A0A3Q1LGL7, A0A3Q1N9E9
      Conserved Domains (6) summary
      smart00282
      Location:860 → 1014
      LamG; Laminin G domain
      cd00055
      Location:187 → 238
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00110
      Location:1487 → 1625
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam06009
      Location:734 → 861
      Laminin_II; Laminin Domain II
      pfam06008
      Location:298 → 554
      Laminin_I; Laminin Domain I
      cl25732
      Location:407 → 747
      SMC_N; RecF/RecN/SMC N terminal domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037336.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      38176073..38331079
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024996681.2 → XP_024852449.1  laminin subunit alpha-4 isoform X3

    2. XM_024996679.2 → XP_024852447.1  laminin subunit alpha-4 isoform X1

      UniProtKB/TrEMBL
      A0A3Q1LGL7, A0A3Q1N9E9
      Related
      ENSBTAP00070006710.1, ENSBTAT00070011887.1
      Conserved Domains (6) summary
      smart00282
      Location:860 → 1014
      LamG; Laminin G domain
      cd00055
      Location:187 → 238
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00110
      Location:1487 → 1625
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam06009
      Location:734 → 861
      Laminin_II; Laminin Domain II
      pfam06008
      Location:298 → 554
      Laminin_I; Laminin Domain I
      cl25732
      Location:407 → 747
      SMC_N; RecF/RecN/SMC N terminal domain

    3. XM_024996680.2 → XP_024852448.1  laminin subunit alpha-4 isoform X2

      UniProtKB/TrEMBL
      A0A3Q1LGL7
      Related
      ENSBTAP00070006707.1, ENSBTAT00070011878.1
      Conserved Domains (6) summary
      smart00282
      Location:853 → 1007
      LamG; Laminin G domain
      cd00055
      Location:187 → 238
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00110
      Location:1480 → 1618
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam06009
      Location:727 → 854
      Laminin_II; Laminin Domain II
      pfam06008
      Location:291 → 547
      Laminin_I; Laminin Domain I
      cl25732
      Location:400 → 740
      SMC_N; RecF/RecN/SMC N terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version

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