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    ENSA endosulfine alpha [ Bos taurus (domestic cattle) ]

    Gene ID: 281142, updated on 27-Dec-2024

    Summary

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    Official Symbol
    ENSAprovided by VGNC
    Official Full Name
    endosulfine alphaprovided by VGNC
    Primary source
    VGNC:VGNC:50171
    See related
    BGD:BT25170; Ensembl:ENSBTAG00000007123
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See ENSA in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 3 NC_037330.1 (20098776..20105592)

    Chromosome 3 - NC_037330.1Genomic Context describing neighboring genes Neighboring gene golgi phosphoprotein 3 like Neighboring gene enhancer of rudimentary homolog Neighboring gene ubiquitin-ribosomal protein eS31 fusion protein-like Neighboring gene uncharacterized LOC112445951 Neighboring gene MCL1 apoptosis regulator, BCL2 family member

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037330.1 Chromosome 3 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Endosulfine, endogenous ligand for the sulphonylurea receptor: isolation from porcine brain and partial structural determination of the alpha form. Virsolvy-Vergine A, et al. Diabetologia, 1996 Feb. PMID 8635664
    2. Alpha endosulfine is a novel molecule, structurally related to a family of phosphoproteins. Peyrollier K, et al. Biochem Biophys Res Commun, 1996 Jun 25. PMID 8687439
    3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC137433

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein phosphatase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    alpha-endosulfine
    Names
    ARPP-19e

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001314005.1 → NP_001300934.1  alpha-endosulfine isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon and its 3' terminal exon extends past a splice site that is used in variant 1. This results in an early stop codon and novel 3' UTR, compared to variant 1. It encodes isoform 2, which has a shorter C-terminus, compared to isoform 1.
      Source sequence(s)
      EV629449, EV691157, EV751319, NKLS02000003
      UniProtKB/TrEMBL
      A0A140T869, A0AAA9TD15
      Related
      ENSBTAP00000009379.4, ENSBTAT00000009379.5
      Conserved Domains (1) summary
      pfam04667
      Location:33 → 86
      Endosulfine; cAMP-regulated phosphoprotein/endosulfine conserved region

    2. NM_174050.2 → NP_776475.2  alpha-endosulfine isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      EV629449, EV703202, NKLS02000003
      UniProtKB/TrEMBL
      A0AAA9TD15
      Conserved Domains (1) summary
      pfam04667
      Location:33 → 86
      Endosulfine; cAMP-regulated phosphoprotein/endosulfine conserved region

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037330.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      20098776..20105592
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059881532.1 → XP_059737515.1  alpha-endosulfine isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P68210.1 GenPept UniProtKB/Swiss-Prot:P68210

    Gene LinkOut

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