U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ALKBH8 alkB homolog 8, tRNA methyltransferase [ Bos taurus (domestic cattle) ]

    Gene ID: 781788, updated on 1-Jan-2025

    Summary

    Go to the top of the page Help
    Official Symbol
    ALKBH8provided by VGNC
    Official Full Name
    alkB homolog 8, tRNA methyltransferaseprovided by VGNC
    Primary source
    VGNC:VGNC:25839
    See related
    BGD:BT22186; Ensembl:ENSBTAG00000010642
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See ALKBH8 in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 15 NC_037342.1 (16933735..17059054, complement)

    Chromosome 15 - NC_037342.1Genomic Context describing neighboring genes Neighboring gene guanylate cyclase 1 soluble subunit alpha 2 Neighboring gene uncharacterized LOC112441599 Neighboring gene U6atac minor spliceosomal RNA Neighboring gene ELMO domain containing 1

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_037342.1 Chromosome 15 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Clone Names

    • MGC152202

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables 2-oxoglutarate-dependent dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables S-adenosylmethionine-dependent methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables tRNA (5-carboxymethyluridine(34)-5-O)-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in tRNA methylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in tRNA wobble uridine modification IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    tRNA (carboxymethyluridine(34)-5-O)-methyltransferase ALKBH8
    Names
    S-adenosyl-L-methionine-dependent tRNA methyltransferase ABH8
    S-adenosyl-L-methionine-dependent tRNA methyltransferase ALKBH8
    alkB, alkylation repair homolog 8
    alkylated DNA repair protein alkB homolog 8
    alpha-ketoglutarate-dependent dioxygenase ALKBH8
    probable alpha-ketoglutarate-dependent dioxygenase ABH8
    tRNA (carboxymethyluridine(34)-5-O)-methyltransferase ABH8
    NP_001073810.2
    XP_010810613.3
    XP_010810614.3

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080341.2 → NP_001073810.2  tRNA (carboxymethyluridine(34)-5-O)-methyltransferase ALKBH8

      Status: VALIDATED

      Source sequence(s)
      BC126687
      UniProtKB/TrEMBL
      A0AAA9S070
      Related
      ENSBTAP00000014068.7, ENSBTAT00000014068.7
      Conserved Domains (4) summary
      pfam09004
      Location:8 → 44
      DUF1891; Domain of unknown function (DUF1891)
      cd12431
      Location:49 → 129
      RRM_ALKBH8; RNA recognition motif in alkylated DNA repair protein alkB homolog 8 (ALKBH8) and similar proteins
      pfam08241
      Location:419 → 508
      Methyltransf_11; Methyltransferase domain
      cl21496
      Location:140 → 310
      2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037342.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      16933735..17059054 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_010812311.4 → XP_010810613.3  tRNA (carboxymethyluridine(34)-5-O)-methyltransferase ALKBH8 isoform X1

      UniProtKB/TrEMBL
      A0A452DJ58
      Conserved Domains (4) summary
      pfam09004
      Location:18 → 54
      DUF1891; Domain of unknown function (DUF1891)
      pfam13649
      Location:406 → 493
      Methyltransf_25; Methyltransferase domain
      cl17169
      Location:59 → 127
      RRM_SF; RNA recognition motif (RRM) superfamily
      cl21496
      Location:129 → 299
      2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily

    2. XM_010812312.4 → XP_010810614.3  tRNA (carboxymethyluridine(34)-5-O)-methyltransferase ALKBH8 isoform X2

      UniProtKB/TrEMBL
      A0AAF7APZ8
      Related
      ENSBTAP00000072553.2, ENSBTAT00000079911.2
      Conserved Domains (4) summary
      pfam09004
      Location:18 → 54
      DUF1891; Domain of unknown function (DUF1891)
      cd12431
      Location:59 → 139
      RRM_ALKBH8; RNA recognition motif in alkylated DNA repair protein alkB homolog 8 (ALKBH8) and similar proteins
      pfam13649
      Location:395 → 482
      Methyltransf_25; Methyltransferase domain
      cl21496
      Location:186 → 288
      2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1A4L5.1 GenPept UniProtKB/Swiss-Prot:A1A4L5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials