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    PCSK7 proprotein convertase subtilisin/kexin type 7 [ Bos taurus (domestic cattle) ]

    Gene ID: 515398, updated on 28-Dec-2024

    Summary

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    Official Symbol
    PCSK7provided by VGNC
    Official Full Name
    proprotein convertase subtilisin/kexin type 7provided by VGNC
    Primary source
    VGNC:VGNC:32649
    See related
    BGD:BT22525; Ensembl:ENSBTAG00000003052
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See PCSK7 in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 15 NC_037342.1 (27895050..27924405, complement)

    Chromosome 15 - NC_037342.1Genomic Context describing neighboring genes Neighboring gene SID1 transmembrane family member 2 Neighboring gene transgelin Neighboring gene ring finger protein 214 Neighboring gene small nucleolar RNA SNORA8 Neighboring gene beta-secretase 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037342.1 Chromosome 15 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein processing IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in trans-Golgi network IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    proprotein convertase subtilisin/kexin type 7
    NP_001179907.1
    XP_005215896.1
    XP_024831015.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001192978.2 → NP_001179907.1  proprotein convertase subtilisin/kexin type 7

      See identical proteins and their annotated locations for NP_001179907.1

      Status: PROVISIONAL

      Source sequence(s)
      NKLS02000015
      UniProtKB/TrEMBL
      A0A8J8YSL8, A0AAA9TJ95, E1BEJ2, V6F9B2
      Related
      ENSBTAP00000039868.4, ENSBTAT00000040088.5
      Conserved Domains (3) summary
      cd04059
      Location:145 → 440
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      pfam01483
      Location:525 → 612
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:53 → 141
      S8_pro-domain; Peptidase S8 pro-domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037342.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      27895050..27924405 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024975247.2 → XP_024831015.1  proprotein convertase subtilisin/kexin type 7 isoform X1

      UniProtKB/TrEMBL
      A0A8J8YSL8, A0AAA9TJ95, E1BEJ2, V6F9B2
      Conserved Domains (3) summary
      cd04059
      Location:145 → 440
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      pfam01483
      Location:525 → 612
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:53 → 141
      S8_pro-domain; Peptidase S8 pro-domain

    2. XM_005215839.5 → XP_005215896.1  proprotein convertase subtilisin/kexin type 7 isoform X1

      See identical proteins and their annotated locations for XP_005215896.1

      UniProtKB/TrEMBL
      A0A8J8YSL8, A0AAA9TJ95, E1BEJ2, V6F9B2
      Related
      ENSBTAP00000098528.1, ENSBTAT00000123655.1
      Conserved Domains (3) summary
      cd04059
      Location:145 → 440
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      pfam01483
      Location:525 → 612
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:53 → 141
      S8_pro-domain; Peptidase S8 pro-domain
    Nucleotide Protein Strain
    Heading Accession and Version

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