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    UPK2 uroplakin 2 [ Bos taurus (domestic cattle) ]

    Gene ID: 281569, updated on 27-Dec-2024

    Summary

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    Official Symbol
    UPK2provided by VGNC
    Official Full Name
    uroplakin 2provided by VGNC
    Primary source
    VGNC:VGNC:36686
    See related
    BGD:BT16362; Ensembl:ENSBTAG00000012750
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See UPK2 in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 15 NC_037342.1 (29529296..29548145)

    Chromosome 15 - NC_037342.1Genomic Context describing neighboring genes Neighboring gene C-X-C motif chemokine receptor 5 Neighboring gene BCL9 like Neighboring gene forkhead box R1 Neighboring gene centrosomal AT-AC splicing factor Neighboring gene ribosomal protein S25

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037342.1 Chromosome 15 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Precursor sequence, processing, and urothelium-specific expression of a major 15-kDa protein subunit of asymmetric unit membrane. Lin JH, et al. J Biol Chem, 1994 Jan 21. PMID 7507484
    2. Organization of uroplakin subunits: transmembrane topology, pair formation and plaque composition. Liang FX, et al. Biochem J, 2001 Apr 1. PMID 11256943, Free PMC Article
    3. Selective interactions of UPIa and UPIb, two members of the transmembrane 4 superfamily, with distinct single transmembrane-domained proteins in differentiated urothelial cells. Wu XR, et al. J Biol Chem, 1995 Dec 15. PMID 8530366
    4. Specific heterodimer formation is a prerequisite for uroplakins to exit from the endoplasmic reticulum. Tu L, et al. Mol Biol Cell, 2002 Dec. PMID 12475947, Free PMC Article
    5. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Process Evidence Code Pubs
    involved_in epithelial cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uroplakin-2
    Names
    UP2
    UPII
    uroplakin II

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174214.2 → NP_776639.1  uroplakin-2 precursor

      See identical proteins and their annotated locations for NP_776639.1

      Status: PROVISIONAL

      Source sequence(s)
      L20633
      UniProtKB/Swiss-Prot
      Q08537
      Conserved Domains (1) summary
      cl06408
      Location:25 → 185
      UP_III_II; Uroplakin IIIb, IIIa and II

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037342.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      29529296..29548145
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_010812417.4 → XP_010810719.1  uroplakin-2 isoform X1

      See identical proteins and their annotated locations for XP_010810719.1

      UniProtKB/Swiss-Prot
      Q08537
      Related
      ENSBTAP00000016947.4, ENSBTAT00000016947.5
      Conserved Domains (1) summary
      cl06408
      Location:25 → 185
      UP_III_II; Uroplakin IIIb, IIIa and II
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08537.1 GenPept UniProtKB/Swiss-Prot:Q08537

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