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    Parp3 poly (ADP-ribose) polymerase family, member 3 [ Mus musculus (house mouse) ]

    Gene ID: 235587, updated on 4-Jan-2025

    Summary

    Official Symbol
    Parp3provided by MGI
    Official Full Name
    poly (ADP-ribose) polymerase family, member 3provided by MGI
    Primary source
    MGI:MGI:1891258
    See related
    Ensembl:ENSMUSG00000023249 AllianceGenome:MGI:1891258
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ARTD3; Adprt3; PARP-3; ADPRT-3; Adprtl3; pADPRT-3; A930002C11Rik
    Summary
    Predicted to enable pentosyltransferase activity. Involved in negative regulation of isotype switching. Acts upstream of or within double-strand break repair. Located in site of double-strand break. Is expressed in primordial germ cell of gonad. Orthologous to human PARP3 (poly(ADP-ribose) polymerase family member 3). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Broad expression in subcutaneous fat pad adult (RPKM 25.0), bladder adult (RPKM 19.6) and 18 other tissues See more
    Orthologs
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    Genomic context

    See Parp3 in Genome Data Viewer
    Location:
    9 F1; 9 57.58 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (106347521..106354148, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (106470322..106476949, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene abhydrolase domain containing 14A Neighboring gene abhydrolase domain containing 14b Neighboring gene poly(rC) binding protein 4 Neighboring gene G protein-coupled receptor 62 Neighboring gene STARR-positive B cell enhancer ABC_E716 Neighboring gene ribosomal RNA processing 9, U3 small nucleolar RNA binding protein Neighboring gene STARR-seq mESC enhancer starr_25152 Neighboring gene IQ motif containing F1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NAD DNA ADP-ribosyltransferase activity  
    enables NAD DNA ADP-ribosyltransferase activity  
    enables NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity  
    enables NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity  
    enables NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity  
    enables NAD+-protein ADP-ribosyltransferase activity  
    enables NAD+-protein ADP-ribosyltransferase activity  
    enables NAD+-protein poly-ADP-ribosyltransferase activity  
    enables NAD+-protein poly-ADP-ribosyltransferase activity  
    enables NAD+-protein-aspartate ADP-ribosyltransferase activity  
    enables NAD+-protein-aspartate ADP-ribosyltransferase activity  
    enables NAD+-protein-glutamate ADP-ribosyltransferase activity  
    enables NAD+-protein-lysine ADP-ribosyltransferase activity  
    enables NAD+-protein-lysine ADP-ribosyltransferase activity  
    enables nucleotidyltransferase activity  
    Process Evidence Code Pubs
    involved_in DNA ADP-ribosylation  
    involved_in DNA ADP-ribosylation  
    involved_in double-strand break repair  
    acts_upstream_of_or_within double-strand break repair PubMed 
    acts_upstream_of_or_within double-strand break repair  
    involved_in negative regulation of isotype switching PubMed 
    acts_upstream_of_or_within positive regulation of DNA ligation  
    involved_in positive regulation of double-strand break repair via nonhomologous end joining  
    involved_in positive regulation of double-strand break repair via nonhomologous end joining  
    involved_in protein auto-ADP-ribosylation  
    involved_in protein auto-ADP-ribosylation  
    acts_upstream_of_or_within protein localization to site of double-strand break  
    acts_upstream_of_or_within regulation of mitotic spindle organization  
    acts_upstream_of_or_within telomere maintenance  
    Component Evidence Code Pubs
    located_in centriole  
    located_in centrosome  
    located_in cytoplasm  
    located_in intercellular bridge  
    located_in intercellular bridge  
    located_in nuclear body  
    located_in nuclear body  
    is_active_in nucleolus  
    located_in nucleoplasm  
    is_active_in site of double-strand break  
    located_in site of double-strand break PubMed 
    located_in site of double-strand break  

    General protein information

    Preferred Names
    protein mono-ADP-ribosyltransferase PARP3
    Names
    A DP-ribosyltransferase (NAD+; poly (ADP-ribose polymerase)-like 3
    ADP-ribosyltransferase (NAD+, poly (ADP-ribose polymerase)-like 3
    ADP-ribosyltransferase diphtheria toxin-like 3
    DNA ADP-ribosyltransferase PARP3
    NAD(+) ADP-ribosyltransferase 3
    NAD+ ADP-ribosyltransferase 3
    Poly[ADP-ribose] synthetase-3
    poly [ADP-ribose] polymerase 3
    poly[ADP-ribose] synthase 3
    NP_001298079.1
    NP_663594.2
    XP_006511781.1
    XP_006511782.1
    XP_006511783.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001311150.1NP_001298079.1  protein mono-ADP-ribosyltransferase PARP3 isoform 1

      See identical proteins and their annotated locations for NP_001298079.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AF368233, AK044223, AK147868
      Consensus CDS
      CCDS81066.1
      UniProtKB/Swiss-Prot
      A0A1L1SRP6, E9PX17, E9Q992, Q3UGL7, Q3ULW8, Q8BHN6, Q8BXU2, Q8CFB8, Q91YR6
      Related
      ENSMUSP00000108098.3, ENSMUST00000112479.9
      Conserved Domains (2) summary
      cd01437
      Location:181532
      parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...
      cl01581
      Location:56154
      WGR; WGR domain
    2. NM_145619.3NP_663594.2  protein mono-ADP-ribosyltransferase PARP3 isoform 2

      See identical proteins and their annotated locations for NP_663594.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AF368233, AK147868
      Consensus CDS
      CCDS23480.1
      UniProtKB/TrEMBL
      Q3UGL7, Q8CFB8
      Related
      ENSMUSP00000064513.8, ENSMUST00000067218.14
      Conserved Domains (2) summary
      cd01437
      Location:176527
      parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...
      cl01581
      Location:56154
      WGR; WGR domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      106347521..106354148 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006511719.4XP_006511782.1  protein mono-ADP-ribosyltransferase PARP3 isoform X1

      See identical proteins and their annotated locations for XP_006511782.1

      UniProtKB/Swiss-Prot
      A0A1L1SRP6, E9PX17, E9Q992, Q3UGL7, Q3ULW8, Q8BHN6, Q8BXU2, Q8CFB8, Q91YR6
      Conserved Domains (2) summary
      cd01437
      Location:181532
      parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...
      cl01581
      Location:56154
      WGR; WGR domain
    2. XM_006511720.2XP_006511783.1  protein mono-ADP-ribosyltransferase PARP3 isoform X2

      See identical proteins and their annotated locations for XP_006511783.1

      UniProtKB/TrEMBL
      Q8CFB8
      Related
      ENSMUSP00000123054.2, ENSMUST00000123555.8
      Conserved Domains (2) summary
      cd01437
      Location:176527
      parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...
      cl01581
      Location:56154
      WGR; WGR domain
    3. XM_006511718.1XP_006511781.1  protein mono-ADP-ribosyltransferase PARP3 isoform X1

      See identical proteins and their annotated locations for XP_006511781.1

      UniProtKB/Swiss-Prot
      A0A1L1SRP6, E9PX17, E9Q992, Q3UGL7, Q3ULW8, Q8BHN6, Q8BXU2, Q8CFB8, Q91YR6
      Conserved Domains (2) summary
      cd01437
      Location:181532
      parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...
      cl01581
      Location:56154
      WGR; WGR domain

    RNA

    1. XR_004935426.1 RNA Sequence

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