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    Cenpo centromere protein O [ Mus musculus (house mouse) ]

    Gene ID: 52504, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Cenpoprovided by MGI
    Official Full Name
    centromere protein Oprovided by MGI
    Primary source
    MGI:MGI:1923800
    See related
    Ensembl:ENSMUSG00000020652 AllianceGenome:MGI:1923800
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D12Ertd482e; 2810429O05Rik; 8430427C03Rik
    Summary
    Predicted to be involved in centromere complex assembly. Predicted to be located in nuclear body. Predicted to be part of Mis6-Sim4 complex. Is expressed in several structures, including central nervous system; genitourinary system; jaw; sensory organ; and thymus primordium. Orthologous to human CENPO (centromere protein O). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in testis adult (RPKM 4.3), thymus adult (RPKM 4.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cenpo in Genome Data Viewer
    Location:
    12 A1.1; 12 2.02 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (4243548..4284255, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (4195398..4234255, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr12:4082834-4083134 Neighboring gene DnaJ heat shock protein family (Hsp40) member C27 Neighboring gene STARR-seq mESC enhancer starr_31436 Neighboring gene predicted gene, 53749 Neighboring gene adenylate cyclase 3 Neighboring gene ubiquitin associated protein 2-like pseudogene Neighboring gene predicted gene, 29696 Neighboring gene peptidyl-tRNA hydrolase domain containing 1 Neighboring gene nuclear receptor coactivator 1 Neighboring gene STARR-seq mESC enhancer starr_31441 Neighboring gene aurora kinase A pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Structural insights into human CCAN complex assembled onto DNA. Tian T, et al. Cell Discov, 2022 Sep 9. PMID 36085283, Free PMC Article
    2. Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program. Sundberg JP, et al. PLoS One, 2017. PMID 28700664, Free PMC Article
    3. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC36863

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in centromere complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome segregation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Mis6-Sim4 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of inner kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    centromere protein O

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001361641.1 → NP_001348570.1  centromere protein O isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC162932, CT572999
      Consensus CDS
      CCDS88302.1
      UniProtKB/TrEMBL
      B8JK52
      Related
      ENSMUSP00000020981.6, ENSMUST00000020981.12
      Conserved Domains (1) summary
      pfam09496
      Location:22 → 74
      CENP-O; Cenp-O kinetochore centromere component

    2. NM_134046.6 → NP_598807.2  centromere protein O isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC162932, CT572999
      Consensus CDS
      CCDS25788.1
      UniProtKB/Swiss-Prot
      Q8K015, Q8R587, Q9CYY6
      Related
      ENSMUSP00000119136.2, ENSMUST00000140975.8
      Conserved Domains (1) summary
      pfam09496
      Location:143 → 195
      CENP-O; Cenp-O kinetochore centromere component

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      4243548..4284255 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030246807.1 → XP_030102667.1  centromere protein O isoform X3

      UniProtKB/TrEMBL
      B8JK51
      Related
      ENSMUSP00000106799.4, ENSMUST00000111169.10
      Conserved Domains (2) summary
      COG3883
      Location:26 → 116
      CwlO1; Uncharacterized N-terminal domain of peptidoglycan hydrolase CwlO [Function unknown]
      pfam09496
      Location:124 → 195
      CENP-O; Cenp-O kinetochore centromere component

    2. XM_011243884.3 → XP_011242186.1  centromere protein O isoform X3

      UniProtKB/TrEMBL
      B8JK51
      Conserved Domains (2) summary
      COG3883
      Location:26 → 116
      CwlO1; Uncharacterized N-terminal domain of peptidoglycan hydrolase CwlO [Function unknown]
      pfam09496
      Location:124 → 195
      CENP-O; Cenp-O kinetochore centromere component

    3. XM_030246806.1 → XP_030102666.1  centromere protein O isoform X2

      UniProtKB/TrEMBL
      B8JK51
      Conserved Domains (2) summary
      COG3883
      Location:26 → 116
      CwlO1; Uncharacterized N-terminal domain of peptidoglycan hydrolase CwlO [Function unknown]
      pfam09496
      Location:124 → 195
      CENP-O; Cenp-O kinetochore centromere component

    4. XM_011243883.4 → XP_011242185.1  centromere protein O isoform X1

      Conserved Domains (2) summary
      COG3883
      Location:26 → 116
      CwlO1; Uncharacterized N-terminal domain of peptidoglycan hydrolase CwlO [Function unknown]
      pfam09496
      Location:124 → 195
      CENP-O; Cenp-O kinetochore centromere component

    RNA

    1. XR_004937524.1 RNA Sequence

    2. XR_872422.4 RNA Sequence

    3. XR_381196.5 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K015.1 GenPept UniProtKB/Swiss-Prot:Q8K015

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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