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    Dnajc13 DnaJ heat shock protein family (Hsp40) member C13 [ Mus musculus (house mouse) ]

    Gene ID: 235567, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Dnajc13provided by MGI
    Official Full Name
    DnaJ heat shock protein family (Hsp40) member C13provided by MGI
    Primary source
    MGI:MGI:2676368
    See related
    Ensembl:ENSMUSG00000032560 AllianceGenome:MGI:2676368
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rme8; RME-8; Gm1124; mKIAA0678; D030002L11Rik
    Summary
    Predicted to be involved in endosome organization; receptor-mediated endocytosis; and regulation of intracellular transport. Predicted to be located in cytosol and early endosome membrane. Predicted to be part of WASH complex. Predicted to be active in endosome membrane. Is expressed in cerebellum and thymus primordium. Human ortholog(s) of this gene implicated in Parkinson's disease. Orthologous to human DNAJC13 (DnaJ heat shock protein family (Hsp40) member C13). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 11.9), kidney adult (RPKM 9.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dnajc13 in Genome Data Viewer
    Location:
    9 F1; 9 56.61 cM
    Exon count:
    59
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (104028796..104140807, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (104151597..104263608, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:103965595-103965778 Neighboring gene STARR-seq mESC enhancer starr_25105 Neighboring gene STARR-seq mESC enhancer starr_25106 Neighboring gene ubiquitin-like modifier activating enzyme 5 Neighboring gene acyl-Coenzyme A dehydrogenase family, member 11 Neighboring gene atypical chemokine receptor 4 Neighboring gene STARR-seq mESC enhancer starr_25110 Neighboring gene high mobility group box 1, related sequence 16 Neighboring gene predicted gene, 46130 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:104146526-104146727 Neighboring gene STARR-positive B cell enhancer ABC_E8310 Neighboring gene acid phosphatase 3 Neighboring gene STARR-seq mESC enhancer starr_25113 Neighboring gene predicted gene 28548

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. DNAJC13 p.Asn855Ser, implicated in familial parkinsonism, alters membrane dynamics of sorting nexin 1. Follett J, et al. Neurosci Lett, 2019 Jul 27. PMID 31082451
    2. A conserved requirement for RME-8/DNAJC13 in neuronal autophagic lysosome reformation. Swords SB, et al. Autophagy, 2024 Apr. PMID 37942902, Free PMC Article
    3. DYRK1a mediates BAFF-induced noncanonical NF-κB activation to promote autoimmunity and B-cell leukemogenesis. Li Y, et al. Blood, 2021 Dec 9. PMID 34255829, Free PMC Article
    4. Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2002 Oct 31. PMID 12465718
    5. Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST. Nakano Y, et al. Cell Rep, 2019 Apr 16. PMID 30995482, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A conserved requirement for RME-8/DNAJC13 in neuronal autophagic lysosome reformation.
      Title: A conserved requirement for RME-8/DNAJC13 in neuronal autophagic lysosome reformation.
    2. Dnajc13 p.Asn855Ser disrupts sorting nexin 1 membrane-tubulation and trafficking
      Title: DNAJC13 p.Asn855Ser, implicated in familial parkinsonism, alters membrane dynamics of sorting nexin 1.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0678

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in endosome organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in receptor-mediated endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of early endosome to late endosome transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of early endosome to recycling endosome transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of WASH complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    dnaJ homolog subfamily C member 13
    Names
    DnaJ (Hsp40) homolog, subfamily C, member 13
    j-domain containing protein, required for endocytosis
    receptor mediated endocytosis RME-8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163026.1 → NP_001156498.1  dnaJ homolog subfamily C member 13 isoform 2

      See identical proteins and their annotated locations for NP_001156498.1

      Status: VALIDATED

      Source sequence(s)
      AB093258, AK083408, AK165345, CD355544, CN457549, CN534380, CO045605, CV884028
      Consensus CDS
      CCDS52904.1
      UniProtKB/TrEMBL
      G3X922
      Related
      ENSMUSP00000035170.7, ENSMUST00000035170.13
      Conserved Domains (2) summary
      pfam00226
      Location:1301 → 1354
      DnaJ; DnaJ domain
      pfam14237
      Location:976 → 1020
      DUF4339; Domain of unknown function (DUF4339)

    2. NM_001359740.1 → NP_001346669.1  dnaJ homolog subfamily C member 13 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC145736, CT030733
      Consensus CDS
      CCDS90651.1
      UniProtKB/TrEMBL
      D4AFX7
      Related
      ENSMUSP00000139804.2, ENSMUST00000186788.7
      Conserved Domains (2) summary
      pfam00226
      Location:1306 → 1359
      DnaJ; DnaJ domain
      pfam14237
      Location:981 → 1025
      DUF4339; Domain of unknown function (DUF4339)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      104028796..104140807 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030244342.1 → XP_030100202.1  dnaJ homolog subfamily C member 13 isoform X1

      UniProtKB/TrEMBL
      Q8CHD7
      Conserved Domains (1) summary
      pfam00226
      Location:192 → 245
      DnaJ; DnaJ domain

    RNA

    1. XR_871081.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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