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    Fat3 FAT atypical cadherin 3 [ Mus musculus (house mouse) ]

    Gene ID: 270120, updated on 3-Dec-2024

    Summary

    Official Symbol
    Fat3provided by MGI
    Official Full Name
    FAT atypical cadherin 3provided by MGI
    Primary source
    MGI:MGI:2444314
    See related
    Ensembl:ENSMUSG00000074505 AllianceGenome:MGI:2444314
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm510; Gm1132; MFAT3F; 9430076A06Rik; D430038H04Rik
    Summary
    Predicted to enable calcium ion binding activity. Acts upstream of or within generation of neurons; negative regulation of dendrite development; and retina layer formation. Located in dendrite. Is expressed in several structures, including brain; foregut; ganglia; sensory organ; and skeleton. Orthologous to human FAT3 (FAT atypical cadherin 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in whole brain E14.5 (RPKM 3.7), frontal lobe adult (RPKM 3.2) and 12 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Fat3 in Genome Data Viewer
    Location:
    9 A2; 9 5.16 cM
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (15821485..16413981, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (15910189..16502681, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 36 (proton/amino acid symporter), member 4 Neighboring gene STARR-seq mESC enhancer starr_23387 Neighboring gene melatonin receptor 1B Neighboring gene STARR-seq mESC enhancer starr_23388 Neighboring gene STARR-seq mESC enhancer starr_23389 Neighboring gene STARR-seq mESC enhancer starr_23390 Neighboring gene STARR-seq mESC enhancer starr_23391 Neighboring gene STARR-seq mESC enhancer starr_23392 Neighboring gene STARR-seq mESC enhancer starr_23393 Neighboring gene predicted gene, 53499 Neighboring gene STARR-seq mESC enhancer starr_23398 Neighboring gene STARR-seq mESC enhancer starr_23400 Neighboring gene STARR-seq mESC enhancer starr_23401 Neighboring gene STARR-seq mESC enhancer starr_23402 Neighboring gene nucleophosmin 1 pseudogene Neighboring gene predicted gene, 53500

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    General protein information

    Preferred Names
    protocadherin Fat 3
    Names
    FAT tumor suppressor homolog 3
    protocadherin Fat3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080814.2NP_001074283.2  protocadherin Fat 3 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC154406, AC154741, AC159817, AC161370, AC162903
      Consensus CDS
      CCDS40539.2
      UniProtKB/Swiss-Prot
      Q08ED4, Q8BNA6
      UniProtKB/TrEMBL
      E9QK16
      Related
      ENSMUSP00000080808.6, ENSMUST00000082170.6
      Conserved Domains (4) summary
      cd11304
      Location:10481143
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:285372
      CA; Cadherin repeats
      cd00054
      Location:40974132
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam02210
      Location:38643992
      Laminin_G_2; Laminin G domain
    2. NM_001413471.1NP_001400400.1  protocadherin Fat 3 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC154406, AC154741, AC159817, AC161370, AC162903
      UniProtKB/TrEMBL
      E9QK16

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      15821485..16413981 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011242542.4XP_011240844.1  protocadherin Fat 3 isoform X5

      UniProtKB/TrEMBL
      E9QK16
      Conserved Domains (4) summary
      cd11304
      Location:10491144
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:286373
      CA; Cadherin repeats
      cd00054
      Location:41214156
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam02210
      Location:38884014
      Laminin_G_2; Laminin G domain
    2. XM_011242541.4XP_011240843.1  protocadherin Fat 3 isoform X3

      UniProtKB/TrEMBL
      E9QK16
      Conserved Domains (4) summary
      cd11304
      Location:10491144
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:286373
      CA; Cadherin repeats
      cd00054
      Location:41214156
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam02210
      Location:38884014
      Laminin_G_2; Laminin G domain
    3. XM_017313398.3XP_017168887.1  protocadherin Fat 3 isoform X2

      UniProtKB/TrEMBL
      E9QK16
      Conserved Domains (4) summary
      cd11304
      Location:10491144
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:286373
      CA; Cadherin repeats
      cd00054
      Location:41214156
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam02210
      Location:38884014
      Laminin_G_2; Laminin G domain
    4. XM_011242543.4XP_011240845.1  protocadherin Fat 3 isoform X1

      UniProtKB/TrEMBL
      E9QK16
      Conserved Domains (4) summary
      cd11304
      Location:10491144
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:286373
      CA; Cadherin repeats
      cd00054
      Location:41214156
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam02210
      Location:38884014
      Laminin_G_2; Laminin G domain
    5. XM_030244399.2XP_030100259.1  protocadherin Fat 3 isoform X6

      Conserved Domains (3) summary
      cd11304
      Location:21072203
      Cadherin_repeat; Cadherin tandem repeat domain
      cd00054
      Location:29642999
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam02210
      Location:27312857
      Laminin_G_2; Laminin G domain
    6. XM_036155026.1XP_036010919.1  protocadherin Fat 3 isoform X7

      Conserved Domains (2) summary
      cd11304
      Location:10491144
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:286373
      CA; Cadherin repeats
    7. XM_036155027.1XP_036010920.1  protocadherin Fat 3 isoform X8

      Conserved Domains (2) summary
      cd11304
      Location:10491144
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:286373
      CA; Cadherin repeats