Klra8 killer cell lectin-like receptor, subfamily A, member 8 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Klra8provided by MGI
Official Full Name: killer cell lectin-like receptor, subfamily A, member 8provided by MGI
Primary source: MGI:MGI:102968
See related: Ensembl:ENSMUSG00000089727 AllianceGenome:MGI:102968
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cmv1; Cmv-1; Ly49h; Ly49u<129>
Summary: Predicted to enable signaling receptor activity. Acts upstream of or within response to virus. Located in cell surface. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: 6 F3; 6 63.44 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (130092189..130106861, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (130115226..130129898, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Furthermore, Ly49/MHC-I interactions are diffusion-controlled and enthalpy-driven.
Title: Kinetic and thermodynamic studies of the interaction between activating and inhibitory Ly49 natural killer receptors and MHC class I molecules.
Ly49H has a role in antiviral activity.
Title: Targeting of a natural killer cell receptor family by a viral immunoevasin.
Signaling through the Ly49H receptor is necessary to induce transient Ly49H-mediated natural killer (NK) cell tolerance during chronic viral infection.
Title: Activation receptor-induced tolerance of mature NK cells in vivo requires signaling through the receptor and is reversible.
m157 gene(G1F)-Ly49C interactions cause no apparent attenuating effect on clearance of murine cytomegalovirus from natural killer (NK) cells.
Title: Functional consequences of natural sequence variation of murine cytomegalovirus m157 for Ly49 receptor specificity and NK cell activation.
Ly49H-regulated NK-cell control of murine CMV infection is dependent on pfp-mediated cytolysis.
Title: The roles of interferon-gamma and perforin in antiviral immunity in mice that differ in genetically determined NK-cell-mediated antiviral activity.
NK cell expansion is increased through an Ly49H-dependent pathway to promote alternative beneficial effects.
Title: Activating receptors promote NK cell expansion for maintenance, IL-10 production, and CD8 T cell regulation during viral infection.
Optimal natural killer cell-mediated immunity to cytomegalovirus depends on Ly49H signaling through DAP10 and DAP12.
Title: Ly49H signaling through DAP10 is essential for optimal natural killer cell responses to mouse cytomegalovirus infection.
these data demonstrate that DAP10 does associate with Ly49H and Ly49D in primary NK cells.
Title: DAP10 associates with Ly49 receptors but contributes minimally to their expression and function in vivo.
Ly49H-positive natural killer (NK) cells contain a systemic production of cytokines that may contribute to murine cytomegalovirus-induced pathology and play a central role in maintaining normal spleen cell microarchitecture.
Title: Ly49h-deficient C57BL/6 mice: a new mouse cytomegalovirus-susceptible model remains resistant to unrelated pathogens controlled by the NK gene complex.
Ly49h is necessary for genetic resistance to murine cytomegalovirus.
Title: Ly49h is necessary for genetic resistance to murine cytomegalovirus.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Not Applicable (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Klra8 (e-PCR), detects polymorphism
- UniSTS:143718

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to virus	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: killer cell lectin-like receptor 8

Names: T-cell surface glycoprotein Ly-49H; cytomegalovirus resistance 1; ly-49h; lymphocyte antigen 49h

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001101620.1 → NP_001095090.1 killer cell lectin-like receptor 8 isoform 1

See identical proteins and their annotated locations for NP_001095090.1

Status: VALIDATED

Description

Transcript Variant: represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC090127

Consensus CDS

CCDS51927.1

UniProtKB/Swiss-Prot

O78027, Q60682

UniProtKB/TrEMBL

Q4Z8P5

Related

ENSMUSP00000014476.6, ENSMUST00000014476.6

Conserved Domains (2) summary

cd03593
Location:145 → 259

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

pfam08391
Location:40 → 157

Ly49; Ly49-like protein, N-terminal region
NM_010650.3 → NP_034780.1 killer cell lectin-like receptor 8 isoform 2

See identical proteins and their annotated locations for NP_034780.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in a shorter protein(isoform 2).

Source sequence(s)

AK143236

UniProtKB/TrEMBL

Q14B13, Q3UPS5

Conserved Domains (2) summary

cd03593
Location:142 → 256

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

pfam08391
Location:38 → 154

Ly49; Ly49-like protein, N-terminal region