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    Fkbp14 FK506 binding protein 14 [ Mus musculus (house mouse) ]

    Gene ID: 231997, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Fkbp14provided by MGI
    Official Full Name
    FK506 binding protein 14provided by MGI
    Primary source
    MGI:MGI:2387639
    See related
    Ensembl:ENSMUSG00000038074 AllianceGenome:MGI:2387639
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FKBP22; FKBP-14
    Summary
    Predicted to enable RNA polymerase II CTD heptapeptide repeat P3 isomerase activity; RNA polymerase II CTD heptapeptide repeat P6 isomerase activity; and calcium ion binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in endoplasmic reticulum lumen. Is expressed in cerebral cortex ventricular layer; cranium; jaw; and thoracic segment skeleton. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome kyphoscoliotic type 2. Orthologous to human FKBP14 (FKBP prolyl isomerase 14). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in limb E14.5 (RPKM 15.3), bladder adult (RPKM 8.2) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fkbp14 in Genome Data Viewer
    Location:
    6 B3; 6 27.01 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (54554590..54574329, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (54577602..54597344, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene WAS/WASL interacting protein family, member 3 Neighboring gene predicted gene, 44026 Neighboring gene secernin 1 Neighboring gene predicted gene, 52863 Neighboring gene pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8 Neighboring gene STARR-seq mESC enhancer starr_15954 Neighboring gene predicted gene, 34249 Neighboring gene maturin, neural progenitor differentiation regulator homolog (Xenopus) Neighboring gene predicted gene, 44008

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Carninci P, et al. Genome Res, 2003 Jun. PMID 12819125, Free PMC Article
    2. Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. Sang L, et al. Cell, 2011 May 13. PMID 21565611, Free PMC Article
    3. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC18737

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA polymerase II CTD heptapeptide repeat P3 isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat P6 isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum lumen IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    peptidyl-prolyl cis-trans isomerase FKBP14
    Names
    PPIase FKBP14
    rotamase
    NP_001350721.1
    NP_001350722.1
    NP_001398495.1
    NP_001398496.1
    NP_001398497.1
    NP_705801.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001363792.1 → NP_001350721.1  peptidyl-prolyl cis-trans isomerase FKBP14 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK163384, BC024846
      Consensus CDS
      CCDS90048.1
      UniProtKB/TrEMBL
      D3YWB6, Q3TQQ3
      Related
      ENSMUSP00000112526.2, ENSMUST00000117375.2
      Conserved Domains (2) summary
      pfam13499
      Location:47 → 110
      EF-hand_7; EF-hand domain pair
      cl27578
      Location:1 → 41
      FKBP_N; Domain amino terminal to FKBP-type peptidyl-prolyl isomerase

    2. NM_001363793.1 → NP_001350722.1  peptidyl-prolyl cis-trans isomerase FKBP14 isoform 3

      Status: VALIDATED

      Source sequence(s)
      BC034313, BY775871
      UniProtKB/TrEMBL
      Q05BQ9
      Conserved Domains (2) summary
      COG0545
      Location:26 → 45
      FkpA; FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein turnover, chaperones]
      pfam13499
      Location:51 → 114
      EF-hand_7; EF-hand domain pair

    3. NM_001411566.1 → NP_001398495.1  peptidyl-prolyl cis-trans isomerase FKBP14 isoform 4 precursor

      Status: VALIDATED

      Source sequence(s)
      AC084800

    4. NM_001411567.1 → NP_001398496.1  peptidyl-prolyl cis-trans isomerase FKBP14 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC084800
      UniProtKB/TrEMBL
      Q05BQ9

    5. NM_001411568.1 → NP_001398497.1  peptidyl-prolyl cis-trans isomerase FKBP14 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC084800

    6. NM_153573.2 → NP_705801.1  peptidyl-prolyl cis-trans isomerase FKBP14 isoform 1 precursor

      See identical proteins and their annotated locations for NP_705801.1

      Status: VALIDATED

      Source sequence(s)
      AK081692, BC024846, BY775871
      Consensus CDS
      CCDS20157.1
      UniProtKB/Swiss-Prot
      P59024
      UniProtKB/TrEMBL
      Q542Q0
      Related
      ENSMUSP00000046070.7, ENSMUST00000046520.13
      Conserved Domains (3) summary
      pfam00254
      Location:38 → 132
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
      pfam13499
      Location:141 → 204
      EF-hand_7; EF-hand domain pair
      cl08302
      Location:142 → 204
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    RNA

    1. NR_177283.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC084800

    2. NR_177284.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC084800
      Related
      ENSMUST00000155047.6

    3. NR_177285.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC084800

    4. NR_177286.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC084800

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      54554590..54574329 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P59024.1 GenPept UniProtKB/Swiss-Prot:P59024

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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