U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Clec12a C-type lectin domain family 12, member a [ Mus musculus (house mouse) ]

    Gene ID: 232413, updated on 27-Nov-2024

    Summary

    Official Symbol
    Clec12aprovided by MGI
    Official Full Name
    C-type lectin domain family 12, member aprovided by MGI
    Primary source
    MGI:MGI:3040968
    See related
    Ensembl:ENSMUSG00000053063 AllianceGenome:MGI:3040968
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Micl; CLL-1; KLRL1; D230024O04
    Summary
    Predicted to enable protein phosphatase binding activity and transmembrane signaling receptor activity. Predicted to be involved in signal transduction. Predicted to act upstream of or within regulation of immune response. Predicted to be located in cell surface. Predicted to be active in plasma membrane. Is expressed in embryo mesenchyme; liver left lobe; liver right lobe; olfactory epithelium; and thymus primordium. Orthologous to human CLEC12A (C-type lectin domain family 12 member A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in liver E18 (RPKM 6.7), liver E14 (RPKM 4.0) and 10 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Clec12a in Genome Data Viewer
    Location:
    6 F3; 6 63.26 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (129327207..129342266)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (129349783..129365303)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6497 Neighboring gene STARR-positive B cell enhancer ABC_E1329 Neighboring gene STARR-positive B cell enhancer ABC_E11735 Neighboring gene STARR-positive B cell enhancer ABC_E1330 Neighboring gene CD69 antigen Neighboring gene STARR-positive B cell enhancer ABC_E3684 Neighboring gene STARR-positive B cell enhancer ABC_E9103 Neighboring gene C-type lectin domain family 2, member m Neighboring gene STARR-seq mESC enhancer starr_17478 Neighboring gene STARR-seq mESC enhancer starr_17479 Neighboring gene STARR-positive B cell enhancer ABC_E6498 Neighboring gene C-type lectin domain family 12, member B Neighboring gene STARR-positive B cell enhancer ABC_E4872 Neighboring gene C-type lectin domain family 1, member b Neighboring gene C-type lectin domain family 9, member a

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (7) 
    • Targeted (2)  1 citation

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables pattern recognition receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables pattern recognition receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables signaling receptor regulator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transmembrane signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transmembrane signaling receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transmembrane signaling receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    C-type lectin domain family 12 member A
    Names
    C-type lectin-like molecule 1
    myeloid inhibitory C-type lectin-like receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177686.4NP_808354.1  C-type lectin domain family 12 member A

      See identical proteins and their annotated locations for NP_808354.1

      Status: VALIDATED

      Source sequence(s)
      AC138620, AK084335, BB850261
      Consensus CDS
      CCDS20584.1
      UniProtKB/Swiss-Prot
      Q504P2, Q8BN96
      UniProtKB/TrEMBL
      A0A0R4J0T2
      Related
      ENSMUSP00000063627.5, ENSMUST00000065289.6
      Conserved Domains (1) summary
      cd03593
      Location:133247
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      129327207..129342266
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)