Ptpra protein tyrosine phosphatase receptor type A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ptpraprovided by MGI
Official Full Name: protein tyrosine phosphatase receptor type Aprovided by MGI
Primary source: MGI:MGI:97808
See related: Ensembl:ENSMUSG00000027303 AllianceGenome:MGI:97808
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ptpa; Rptra; Ptpalpha; Rptpalpha; Rptralpha
Summary: Enables protein tyrosine phosphatase activity. Involved in integrin-mediated signaling pathway; modulation of chemical synaptic transmission; and regulation of focal adhesion assembly. Acts upstream of or within insulin receptor signaling pathway and protein phosphorylation. Located in focal adhesion and membrane. Is active in Schaffer collateral - CA1 synapse and synaptic membrane. Is expressed in several structures, including adrenal gland; central nervous system; extraembryonic component; future brain; and genitourinary system. Orthologous to human PTPRA (protein tyrosine phosphatase receptor type A). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in ovary adult (RPKM 35.2), CNS E18 (RPKM 33.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 F1; 2 63.23 cM

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (130292198..130396220)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (130450278..130554300)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Clustering of phosphatase RPTPalpha promotes Src signaling and the arthritogenic action of synovial fibroblasts.
Title: Clustering of phosphatase RPTPα promotes Src signaling and the arthritogenic action of synovial fibroblasts.
PTPalpha promotes fibroproliferative responses after acute lung injury.
Title: PTPα promotes fibroproliferative responses after acute lung injury.
Roles of Collagen XXV and Its Putative Receptors PTPsigma/delta in Intramuscular Motor Innervation and Congenital Cranial Dysinnervation Disorder.
Title: Roles of Collagen XXV and Its Putative Receptors PTPσ/δ in Intramuscular Motor Innervation and Congenital Cranial Dysinnervation Disorder.
In a model of spinal cord injury, blocking PTPalpha and LAR receptors promotes oligodendrogenesis.
Title: LAR and PTPσ receptors are negative regulators of oligodendrogenesis and oligodendrocyte integrity in spinal cord injury.
PTPalpha coordinates oligodendroglial and neuronal development and myelination.
Title: Glial and Neuronal Protein Tyrosine Phosphatase Alpha (PTPα) Regulate Oligodendrocyte Differentiation and Myelination.
RPTPalpha mediates proinflammatory and proinvasive signaling in rheumatoid arthritis fibroblast-like synoviocytes (FLS), correlating with the promotion of disease in an FLS-dependent model of rheumatoid arthritis.
Title: Receptor Protein Tyrosine Phosphatase α-Mediated Enhancement of Rheumatoid Synovial Fibroblast Signaling and Promotion of Arthritis in Mice.
Ptpra coordinates the regulation of the Fyn signaling pathway in corpus striatum.
Title: Striatal-enriched protein tyrosine phosphatase regulates the PTPα/Fyn signaling pathway.
PTPs alpha and epsilon play distinct roles in osteoclasts.
Title: Protein tyrosine phosphatases ε and α perform nonredundant roles in osteoclasts.
PTP-alpha promotes profibrotic signaling pathways in fibroblasts through control of cellular responsiveness to TGF-beta.
Title: Protein tyrosine phosphatase α mediates profibrotic signaling in lung fibroblasts through TGF-β responsiveness.
The focal adhesion targeting domain of FAK interacts with protein-tyrosine phosphatase-alpha to restrict IL1-induced Ca2+ release, ERK activation, and MMP-9 expression.
Title: Interactions of the protein-tyrosine phosphatase-α with the focal adhesion targeting domain of focal adhesion kinase are involved in interleukin-1 signaling in fibroblasts.

Submit: New GeneRIF Correction See all GeneRIFs (46)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D2Mit78 (e-PCR), detects polymorphism
- UniSTS:129472

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables histone H2AXY142 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein tyrosine phosphatase activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine phosphatase activity, metal-dependent	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within insulin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in integrin-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in modulation of chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in modulation of chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of oligodendrocyte differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of focal adhesion assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in Schaffer collateral - CA1 synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in Schaffer collateral - CA1 synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in focal adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
located_in membrane	IMP Inferred from Mutant Phenotype more info	PubMed
part_of receptor complex	ISO Inferred from Sequence Orthology more info	PubMed
is_active_in synaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in synaptic membrane	IEP Inferred from Expression Pattern more info	PubMed

General protein information

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Preferred Names: receptor-type tyrosine-protein phosphatase alpha

Names: LCA-related phosphatase; PTPTY-28; R-PTP-alpha; protein-tyrosine phosphatase alpha

NP_001157160.1

EC 3.1.3.48

NP_001342090.1

EC 3.1.3.48

NP_033006.2

EC 3.1.3.48

XP_036015592.1

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001163688.1 → NP_001157160.1 receptor-type tyrosine-protein phosphatase alpha isoform 2 precursor

See identical proteins and their annotated locations for NP_001157160.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.

Source sequence(s)

AK010458, AK031690, AK162387

Consensus CDS

CCDS50712.1

UniProtKB/TrEMBL

Q91V35

Related

ENSMUSP00000028769.7, ENSMUST00000028769.14

Conserved Domains (3) summary

smart00194
Location:523 → 781

PTPc; Protein tyrosine phosphatase, catalytic domain

cd00047
Location:551 → 781

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

pfam07010
Location:23 → 170

Endomucin; Endomucin
NM_001355161.1 → NP_001342090.1 receptor-type tyrosine-protein phosphatase alpha isoform 3 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (3) contains an alternate in-frame exon and lacks another alternate in-frame exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AL731707, BX890605

Conserved Domains (3) summary

smart00194
Location:240 → 500

PTPc; Protein tyrosine phosphatase, catalytic domain

cd00047
Location:560 → 790

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cl25495
Location:17 → 179

Endomucin; Endomucin
NM_008980.2 → NP_033006.2 receptor-type tyrosine-protein phosphatase alpha isoform 1 precursor

See identical proteins and their annotated locations for NP_033006.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AK010458, AK031690, AK162387, AL731707

Consensus CDS

CCDS16743.1

UniProtKB/Swiss-Prot

A2AHF2, P18052, Q61808

Related

ENSMUSP00000076533.4, ENSMUST00000077303.4

Conserved Domains (3) summary

smart00194
Location:559 → 817

PTPc; Protein tyrosine phosphatase, catalytic domain

cd00047
Location:587 → 817

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

pfam07010
Location:23 → 170

Endomucin; Endomucin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

130292198..130396220

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036159699.1 → XP_036015592.1 receptor-type tyrosine-protein phosphatase alpha isoform X1

Conserved Domains (2) summary

cd14621
Location:250 → 545

R-PTPc-A-1; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 1

cd14623
Location:599 → 826

R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2