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    Slc6a7 solute carrier family 6 (neurotransmitter transporter, L-proline), member 7 [ Mus musculus (house mouse) ]

    Gene ID: 240332, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Slc6a7provided by MGI
    Official Full Name
    solute carrier family 6 (neurotransmitter transporter, L-proline), member 7provided by MGI
    Primary source
    MGI:MGI:2147363
    See related
    Ensembl:ENSMUSG00000052026 AllianceGenome:MGI:2147363
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PROT
    Summary
    Enables L-proline transmembrane transporter activity. Acts upstream of or within proline transmembrane transport. Predicted to be located in synaptic membrane. Predicted to be active in several cellular components, including Schaffer collateral - CA1 synapse; presynaptic membrane; and synaptic vesicle membrane. Is expressed in brain; early conceptus; metanephros; and secondary oocyte. Orthologous to human SLC6A7 (solute carrier family 6 member 7). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in frontal lobe adult (RPKM 8.4), cortex adult (RPKM 7.4) and 11 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Slc6a7 in Genome Data Viewer
    Location:
    18 E1; 18 34.41 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (61128448..61147484, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (60995376..61014416, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene calcium/calmodulin-dependent protein kinase II alpha Neighboring gene microRNA 7220 Neighboring gene microRNA 6982 Neighboring gene STARR-positive B cell enhancer ABC_E10994 Neighboring gene caudal type homeobox 1 Neighboring gene predicted gene, 52351 Neighboring gene platelet derived growth factor receptor, beta polypeptide

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Inactivation of the Mouse L-Proline Transporter PROT Alters Glutamatergic Synapse Biochemistry and Perturbs Behaviors Required to Respond to Environmental Changes. Schulz D, et al. Front Mol Neurosci, 2018. PMID 30177871, Free PMC Article
    2. SIT1 is a betaine/proline transporter that is activated in mouse eggs after fertilization and functions until the 2-cell stage. Anas MK, et al. Development, 2008 Dec. PMID 19029042
    3. Lhx2 specifies regional fate in Emx1 lineage of telencephalic progenitors generating cerebral cortex. Chou SJ, et al. Nat Neurosci, 2009 Nov. PMID 19820705, Free PMC Article
    4. The repertoire of solute carriers of family 6: identification of new human and rodent genes. Höglund PJ, et al. Biochem Biophys Res Commun, 2005 Oct 14. PMID 16125675
    5. Expansion of the piriform cortex contributes to corticothalamic pathfinding defects in Gli3 conditional mutants. Amaniti EM, et al. Cereb Cortex, 2015 Feb. PMID 24014668

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. We assessed two candidates for the betaine/proline transporter: SIT1 (IMINO; encoded by Slc6a20a) and PROT (Slc6a7). mRNA from both genes was present in eggs and 1-cell embryos.
      Title: SIT1 is a betaine/proline transporter that is activated in mouse eggs after fertilization and functions until the 2-cell stage.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC61029, MGC67444

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables L-proline transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables L-proline transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables proline:sodium symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables proline:sodium symporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables proline:sodium symporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in glycine import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neurotransmitter transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within proline transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proline transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proline transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proline transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sodium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Schaffer collateral - CA1 synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in presynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    sodium-dependent proline transporter
    Names
    solute carrier family 6 member 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418406.1 → NP_001405335.1  sodium-dependent proline transporter isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC124431

    2. NM_201353.2 → NP_958741.1  sodium-dependent proline transporter isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC124431
      Consensus CDS
      CCDS29278.1
      UniProtKB/Swiss-Prot
      Q6PGE7, Q80UM1
      Related
      ENSMUSP00000025520.8, ENSMUST00000025520.10
      Conserved Domains (1) summary
      cl00456
      Location:37 → 581
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      61128448..61147484 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030250459.2 → XP_030106319.1  sodium-dependent proline transporter isoform X3

      Conserved Domains (1) summary
      cl00456
      Location:1 → 500
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    2. XM_006525930.4 → XP_006525993.1  sodium-dependent proline transporter isoform X1

      Conserved Domains (1) summary
      cl00456
      Location:84 → 628
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    3. XM_006525929.4 → XP_006525992.1  sodium-dependent proline transporter isoform X1

      Conserved Domains (1) summary
      cl00456
      Location:84 → 628
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    4. XM_006525931.5 → XP_006525994.1  sodium-dependent proline transporter isoform X2

      Conserved Domains (1) summary
      cl00456
      Location:19 → 563
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    5. XM_006525932.3 → XP_006525995.1  sodium-dependent proline transporter isoform X3

      Conserved Domains (1) summary
      cl00456
      Location:1 → 500
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    6. XM_017317902.3 → XP_017173391.1  sodium-dependent proline transporter isoform X4

      Conserved Domains (1) summary
      cl00456
      Location:84 → 410
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    7. XM_011246931.1 → XP_011245233.1  sodium-dependent proline transporter isoform X5

      Conserved Domains (1) summary
      cl00456
      Location:84 → 336
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    8. XM_006525935.4 → XP_006525998.1  sodium-dependent proline transporter isoform X6

      Conserved Domains (1) summary
      cl00456
      Location:84 → 333
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PGE7.1 GenPept UniProtKB/Swiss-Prot:Q6PGE7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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