Enho energy homeostasis associated [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Enhoprovided by MGI
Official Full Name: energy homeostasis associatedprovided by MGI
Primary source: MGI:MGI:1916888
See related: Ensembl:ENSMUSG00000028445 AllianceGenome:MGI:1916888
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1110065P19Rik; 2310040A07Rik
Summary: Enables hormone activity. Acts upstream of or within positive regulation of Notch signaling pathway. Located in plasma membrane. Is expressed in ductus deferens; epididymis; esophagus; ileum; and prostate gland. Orthologous to human ENHO (energy homeostasis associated). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in bladder adult (RPKM 64.8), cerebellum adult (RPKM 41.1) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 A5; 4 21.8 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (41638144..41640302, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (41638144..41640302, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ontogeny of adropin and its receptor expression during postnatal development and its pro-gonadal role in the ovary of pre-pubertal mouse.
Title: Ontogeny of adropin and its receptor expression during postnatal development and its pro-gonadal role in the ovary of pre-pubertal mouse.
Adropin attenuates pancreatitis-associated lung injury through PPARgamma phosphorylation-related macrophage polarization.
Title: Adropin attenuates pancreatitis‑associated lung injury through PPARγ phosphorylation‑related macrophage polarization.
Selective deficiency of UCP-1 and adropin may lead to different subtypes of anti-neutrophil cytoplasmic antibody-associated vasculitis.
Title: Selective deficiency of UCP-1 and adropin may lead to different subtypes of anti-neutrophil cytoplasmic antibody-associated vasculitis.
Adropin Improves Radiation-Induced Myocardial Injury via VEGFR2/PI3K/Akt Pathway.
Title: Adropin Improves Radiation-Induced Myocardial Injury via VEGFR2/PI3K/Akt Pathway.
Aerobic Exercise Restores Aging-Associated Reductions in Arterial Adropin Levels and Improves Adropin-Induced Nitric Oxide-Dependent Vasorelaxation.
Title: Aerobic Exercise Restores Aging-Associated Reductions in Arterial Adropin Levels and Improves Adropin-Induced Nitric Oxide-Dependent Vasorelaxation.
Lower adropin expression is associated with oxidative stress and severity of nonalcoholic fatty liver disease.
Title: Lower adropin expression is associated with oxidative stress and severity of nonalcoholic fatty liver disease.
Exercise suppresses NLRP3 inflammasome activation in mice with diet-induced NASH: a plausible role of adropin.
Title: Exercise suppresses NLRP3 inflammasome activation in mice with diet-induced NASH: a plausible role of adropin.
Adropin regulates hepatic glucose production via PP2A/AMPK pathway in insulin-resistant hepatocytes.
Title: Adropin regulates hepatic glucose production via PP2A/AMPK pathway in insulin-resistant hepatocytes.
Hepatocyte expression of the micropeptide adropin regulates the liver fasting response and is enhanced by caloric restriction.
Title: Hepatocyte expression of the micropeptide adropin regulates the liver fasting response and is enhanced by caloric restriction.
Adropin reduced lipid accumulation as well as expression of proadipogenic genes in 3T3-L1 cells and rat preadipocytes, suggesting that this protein attenuates differentiation of preadipocytes into mature fat cells. In summary, these results show that adropin modulates proliferation and differentiation of preadipocytes.
Title: Effects of adropin on proliferation and differentiation of 3T3-L1 cells and rat primary preadipocytes.

Submit: New GeneRIF Correction See all GeneRIFs (20)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation
Targeted (5) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables hormone activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in positive regulation of Notch signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of Notch signaling pathway	IEP Inferred from Expression Pattern more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: adropin

Names: energy homeostasis-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.