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    Pex19 peroxisomal biogenesis factor 19 [ Mus musculus (house mouse) ]

    Gene ID: 19298, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Pex19provided by MGI
    Official Full Name
    peroxisomal biogenesis factor 19provided by MGI
    Primary source
    MGI:MGI:1334458
    See related
    Ensembl:ENSMUSG00000003464 AllianceGenome:MGI:1334458
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pxf
    Summary
    Predicted to enable ATPase binding activity; peroxisome membrane class-1 targeting sequence binding activity; and protein carrier chaperone. Predicted to be involved in chaperone-mediated protein folding; peroxisome organization; and protein stabilization. Predicted to be located in several cellular components, including brush border membrane; nucleoplasm; and peroxisome. Predicted to be part of protein-containing complex. Predicted to be active in peroxisomal membrane. Is expressed in several structures, including nervous system; tail; and trunk. Human ortholog(s) of this gene implicated in peroxisome biogenesis disorder 12A. Orthologous to human PEX19 (peroxisomal biogenesis factor 19). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in subcutaneous fat pad adult (RPKM 42.2), mammary gland adult (RPKM 35.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pex19 in Genome Data Viewer
    Location:
    1 H3; 1 79.54 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (171954322..171964064)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (172126755..172136497)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_03049 Neighboring gene nescient helix loop helix 1 Neighboring gene nicastrin Neighboring gene coatomer protein complex subunit alpha Neighboring gene STARR-positive B cell enhancer ABC_E5851 Neighboring gene STARR-seq mESC enhancer starr_03051 Neighboring gene translocase of inner mitochondrial membrane 23 homolog pseudogene Neighboring gene DDB1 and CUL4 associated factor 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Pex19p dampens the p19ARF-p53-p21WAF1 tumor suppressor pathway. Sugihara T, et al. J Biol Chem, 2001 Jun 1. PMID 11259404
    2. Reciprocal Regulation of Peroxisome Biogenesis and Myogenic Factors Is Critical for Myogenesis. Wu CC, et al. Int J Mol Sci, 2023 Jul 31. PMID 37569637, Free PMC Article
    3. 70-kDa peroxisomal membrane protein related protein (P70R/ABCD4) localizes to endoplasmic reticulum not peroxisomes, and NH2-terminal hydrophobic property determines the subcellular localization of ABC subfamily D proteins. Kashiwayama Y, et al. Exp Cell Res, 2009 Jan 15. PMID 19010322
    4. Severe neural tube defects in the loop-tail mouse result from mutation of Lpp1, a novel gene involved in floor plate specification. Murdoch JN, et al. Hum Mol Genet, 2001 Oct 15. PMID 11709546
    5. Ltap, a mammalian homolog of Drosophila Strabismus/Van Gogh, is altered in the mouse neural tube mutant Loop-tail. Kibar Z, et al. Nat Genet, 2001 Jul. PMID 11431695

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peroxisome membrane class-1 targeting sequence binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peroxisome membrane class-1 targeting sequence binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peroxisome membrane targeting sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein carrier chaperone IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein carrier chaperone ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in chaperone-mediated protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chaperone-mediated protein folding ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in establishment of protein localization to peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of lipid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peroxisome fission IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peroxisome fission ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peroxisome membrane biogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peroxisome organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein import into peroxisome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into peroxisome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein import into peroxisome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein stabilization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein targeting to peroxisome IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein targeting to peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in brush border membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in peroxisomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    peroxisomal biogenesis factor 19
    Names
    peroxin-19
    peroxisomal farnesylated protein
    peroxisome biogenesis factor 19

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159525.1 → NP_001152997.1  peroxisomal biogenesis factor 19 isoform b

      See identical proteins and their annotated locations for NP_001152997.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks several alternate exons in the coding region, compared to variant 1. This results in a shorter protein (isoform b) compared to isoform a.
      Source sequence(s)
      AK028449, AK029368
      Consensus CDS
      CCDS48445.1
      UniProtKB/Swiss-Prot
      Q8VCI5
      Related
      ENSMUSP00000106883.4, ENSMUST00000111252.4
      Conserved Domains (1) summary
      pfam04614
      Location:23 → 207
      Pex19; Pex19 protein family

    2. NM_001356513.1 → NP_001343442.1  peroxisomal biogenesis factor 19 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region, which results in a frameshift compared to variant 1. The encoded isoform (c) has a shorter and distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AC074310, AC158930
      UniProtKB/TrEMBL
      Q3TDI5
      Conserved Domains (1) summary
      pfam04614
      Location:74 → 272
      Pex19; Pex19 protein family

    3. NM_001356514.1 → NP_001343443.1  peroxisomal biogenesis factor 19 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (d) is shorter than isoform a.
      Source sequence(s)
      AC074310, AC158930
      UniProtKB/TrEMBL
      Q3TDI5
      Conserved Domains (1) summary
      pfam04614
      Location:74 → 284
      Pex19; Pex19 protein family

    4. NM_023041.3 → NP_075528.3  peroxisomal biogenesis factor 19 isoform a

      See identical proteins and their annotated locations for NP_075528.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AK028449, AK029368, AK075576
      Consensus CDS
      CCDS15508.1
      UniProtKB/Swiss-Prot
      Q4FJU7, Q8CEE1, Q8VCI5, Q921H0, Q9CZC1, Q9QUQ1
      UniProtKB/TrEMBL
      Q3TDI5
      Related
      ENSMUSP00000075289.3, ENSMUST00000075895.9
      Conserved Domains (1) summary
      pfam04614
      Location:74 → 299
      Pex19; Pex19 protein family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      171954322..171964064
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VCI5.1 GenPept UniProtKB/Swiss-Prot:Q8VCI5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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