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    Nlrp4f NLR family, pyrin domain containing 4F [ Mus musculus (house mouse) ]

    Gene ID: 97895, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Nlrp4fprovided by MGI
    Official Full Name
    NLR family, pyrin domain containing 4Fprovided by MGI
    Primary source
    MGI:MGI:2145528
    See related
    Ensembl:ENSMUSG00000032999 AllianceGenome:MGI:2145528
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nalp4f; Nalp-kappa; C330026N02Rik
    Summary
    Predicted to enable molecular adaptor activity. Involved in several processes, including actin filament organization; in utero embryonic development; and positive regulation of embryonic development. Located in cell cortex. Is expressed in several structures, including early conceptus; genitourinary system; hemolymphoid system gland; liver; and muscle tissue. Orthologous to human NLRP4 (NLR family pyrin domain containing 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Nlrp4f in Genome Data Viewer
    Location:
    13 B3; 13 34.45 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (65324925..65353530, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (65177111..65205716, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 9 subfamily S member 18 Neighboring gene predicted gene, 24130 Neighboring gene STARR-seq mESC enhancer starr_34836 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:65341962-65342145 Neighboring gene predicted gene, 36445 Neighboring gene STARR-seq mESC enhancer starr_34838 Neighboring gene STARR-seq mESC enhancer starr_34839 Neighboring gene predicted gene 10775

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The subcortical maternal complex protein Nlrp4f is involved in cytoplasmic lattice formation and organelle distribution. Qin D, et al. Development, 2019 Oct 18. PMID 31575650
    2. In silico identification and structural features of six new genes similar to MATER specifically expressed in the oocyte. Dadé S, et al. Biochem Biophys Res Commun, 2004 Nov 12. PMID 15474461
    3. Differences in gene expression between mouse and human for dynamically regulated genes in early embryo. Madissoon E, et al. PLoS One, 2014. PMID 25089626, Free PMC Article
    4. Ovarian gene expression in the absence of FIGLA, an oocyte-specific transcription factor. Joshi S, et al. BMC Dev Biol, 2007 Jun 13. PMID 17567914, Free PMC Article
    5. NLRP14 deficiency causes female infertility with oocyte maturation defects and early embryonic arrest by impairing cytoplasmic UHRF1 abundance. Zhang W, et al. Cell Rep, 2023 Dec 26. PMID 38060382

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin filament organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment of organelle localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    NACHT, LRR and PYD domains-containing protein 4F
    Names
    NACHT, leucine rich repeat and PYD containing 4F
    NALP, kappa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175290.4 → NP_780499.3  NACHT, LRR and PYD domains-containing protein 4F

      See identical proteins and their annotated locations for NP_780499.3

      Status: VALIDATED

      Source sequence(s)
      AK049352, AK135866, BC098479, CD541102, DV656119
      Consensus CDS
      CCDS49294.1
      UniProtKB/Swiss-Prot
      Q66X05
      UniProtKB/TrEMBL
      L7N1W9
      Related
      ENSMUSP00000041908.8, ENSMUST00000037372.8
      Conserved Domains (6) summary
      COG4886
      Location:630 → 871
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      cd00116
      Location:636 → 926
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      cd08320
      Location:10 → 88
      Pyrin_NALPs; Pyrin death domain found in NALP proteins
      sd00033
      Location:689 → 713
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:718 → 745
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:147 → 315
      NACHT; NACHT domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      65324925..65353530 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q66X05.1 GenPept UniProtKB/Swiss-Prot:Q66X05

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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