Creb3 cAMP responsive element binding protein 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Creb3provided by MGI
Official Full Name: cAMP responsive element binding protein 3provided by MGI
Primary source: MGI:MGI:99946
See related: Ensembl:ENSMUSG00000028466 AllianceGenome:MGI:99946
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: LZIP; Luman; LZIP-1; LZIP-2
Summary: Enables sequence-specific DNA binding activity. Predicted to be involved in several processes, including positive regulation of chemotaxis; positive regulation of deacetylase activity; and regulation of DNA-templated transcription. Predicted to be located in several cellular components, including Golgi membrane; neuronal cell body; and nuclear body. Predicted to be part of RNA polymerase II transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including branchial arch; central nervous system; early conceptus; genitourinary system; and skeleton. Orthologous to human CREB3 (cAMP responsive element binding protein 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 82.8), duodenum adult (RPKM 69.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 A5; 4 23.05 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (43562658..43567061)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (43562658..43567061)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CREB3 mediates the transcriptional regulation of PGC-1alpha, a master regulator of energy homeostasis and mitochondrial biogenesis.
Title: CREB3 mediates the transcriptional regulation of PGC-1α, a master regulator of energy homeostasis and mitochondrial biogenesis.
ER stress-associated transcription factor CREB3 is essential for normal Ca[2+], ATP, and ROS homeostasis.
Title: ER stress-associated transcription factor CREB3 is essential for normal Ca(2+), ATP, and ROS homeostasis.
Transcription factor CREB3 is a potent regulator of high-fat diet-induced obesity and energy metabolism.
Title: Transcription factor CREB3 is a potent regulator of high-fat diet-induced obesity and energy metabolism.
The role of small leucine zipper protein in osteoclastogenesis and its involvement in bone remodeling.
Title: The role of small leucine zipper protein in osteoclastogenesis and its involvement in bone remodeling.
Exploring the role of Luman/CREB3 in regulating decidualization of mice endometrial stromal cells by comparative transcriptomics.
Title: Exploring the role of Luman/CREB3 in regulating decidualization of mice endometrial stromal cells by comparative transcriptomics.
These findings suggest a model whereby SUMO regulates the distribution, oligomerization, and activity of oligomeric CPEB3, a critical player in the persistence of memory.
Title: CPEB3 inhibits translation of mRNA targets by localizing them to P bodies.
This finding is especially true for the unique action of the copper ion on CREB3 stabilization and processing in parallel to aberration of ubiquitin-proteasome system, which might provide new insights into understanding the mechanisms of intractable disorders.
Title: Elucidating post-translational regulation of mouse CREB3 in Neuro2a cells.
LUMAN is a key regulator of glucocorticoid receptor-mediated signaling.
Title: LUMAN/CREB3 is a key regulator of glucocorticoid-mediated stress responses.
Luman regulates mouse granulosa cell modulation of steroid synthesis, cell cycle activity and other regulators of folliculogenesis
Title: Knockdown of CREB3/Luman by shRNA in Mouse Granulosa Cells Results in Decreased Estradiol and Progesterone Synthesis and Promotes Cell Proliferation.
LRF seems to be involved in the regulation of decidualization during pregnancy.
Title: Luman recruiting factor is involved in stromal cell proliferation during decidualization in mice.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1) 1 citation
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW538053 (e-PCR)
- UniSTS:178990

NoName (e-PCR)
- UniSTS:234909

PMC114562P4 (e-PCR)
- UniSTS:270272

C80076 (e-PCR)
- UniSTS:159230

AU044960 (e-PCR)
- UniSTS:159231

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables CCR1 chemokine receptor binding	ISO Inferred from Sequence Orthology more info
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables cAMP response element binding protein binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription coregulator binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in cytoplasmic sequestering of transcription factor	ISO Inferred from Sequence Orthology more info
involved_in cytoplasmic sequestering of transcription factor	ISS Inferred from Sequence or Structural Similarity more info
involved_in endoplasmic reticulum unfolded protein response	ISO Inferred from Sequence Orthology more info
involved_in establishment of viral latency	ISO Inferred from Sequence Orthology more info
involved_in establishment of viral latency	ISS Inferred from Sequence or Structural Similarity more info
involved_in induction of positive chemotaxis	ISO Inferred from Sequence Orthology more info
NOT involved_in induction of positive chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
involved_in induction of positive chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of deacetylase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of deacetylase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of defense response to virus by host	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of defense response to virus by host	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of monocyte chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of monocyte chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell growth	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in release from viral latency	ISO Inferred from Sequence Orthology more info
involved_in release from viral latency	ISS Inferred from Sequence or Structural Similarity more info
NOT involved_in response to endoplasmic reticulum stress	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to unfolded protein	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	ISS Inferred from Sequence or Structural Similarity more info
part_of RNA polymerase II transcription regulator complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	ISO Inferred from Sequence Orthology more info
NOT located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nuclear body	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: cyclic AMP-responsive element-binding protein 3

Names: CREB-3; transcription factor LZIP

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013497.4 → NP_038525.2 cyclic AMP-responsive element-binding protein 3

See identical proteins and their annotated locations for NP_038525.2

Status: VALIDATED

Source sequence(s)

AK132785, BQ746877

Consensus CDS

CCDS18102.1

UniProtKB/Swiss-Prot

Q61817, Q99M21, Q9CVK9

UniProtKB/TrEMBL

Q3UNH6

Related

ENSMUSP00000100008.5, ENSMUST00000102944.11

Conserved Domains (1) summary

cd14689
Location:161 → 221

bZIP_CREB3; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 3 (CREB3) and similar proteins: a DNA-binding and dimerization domain