Brap BRCA1 associated protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Brapprovided by MGI
Official Full Name: BRCA1 associated proteinprovided by MGI
Primary source: MGI:MGI:1919649
See related: Ensembl:ENSMUSG00000029458 AllianceGenome:MGI:1919649
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: IMP; BRAP2; 3010002G07Rik
Summary: Predicted to enable identical protein binding activity; nuclear localization sequence binding activity; and ubiquitin protein ligase activity. Predicted to be involved in Ras protein signal transduction; negative regulation of signal transduction; and protein ubiquitination. Predicted to act upstream of or within MAPK cascade. Predicted to be located in cytosol; nuclear membrane; and nucleoplasm. Predicted to be part of ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in several structures, including central nervous system; dorsal root ganglion; genitourinary system; retina; and vibrissa. Orthologous to human BRAP (BRCA1 associated protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in testis adult (RPKM 46.8), liver adult (RPKM 15.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 F; 5 61.9 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (121798626..121825312)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (121660563..121687249)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Bombesin receptor-activated protein homolog deficiency altered the pattern of pathological changes of psoriasis - like skin lesion in mice.
Title: Bombesin receptor-activated protein homolog deficiency altered the pattern of pathological changes of psoriasis - like skin lesion in mice.
Knockout of the BRAP homolog in mice leads to abnormal tracheal cilia.
Title: Knockout of the BRAP homolog in mice leads to abnormal tracheal cilia.
Control of p21Cip by BRCA1-associated protein is critical for cardiomyocyte cell cycle progression and survival.
Title: Control of p21Cip by BRCA1-associated protein is critical for cardiomyocyte cell cycle progression and survival.
These findings demonstrate that neuronal differentiation is potentiated during G1 phase by Brap-directed cascade of events in cell signaling and protein turnover.
Title: Loss of Brap Results in Premature G1/S Phase Transition and Impeded Neural Progenitor Differentiation.
Together the results indicate for the first time that BRAP2 may play an important NRNI role in germ cells of the testis, with an additional, scaffold/structural role in mature spermatozoa.
Title: Interactome of the negative regulator of nuclear import BRCA1-binding protein 2.
ectopic expression of BRAP2 inhibits nuclear localization of HMG20A and NuMA1, and prevents nuclear envelope accumulation of SYNE2.
Title: The BRCA1-binding protein BRAP2 can act as a cytoplasmic retention factor for nuclear and nuclear envelope-localizing testicular proteins.
A molecular complex composed of Nde1, Lis1, and Brap regulates the dynamic MAPK signaling threshold in a spatially dependent fashion.
Title: Spatially dependent dynamic MAPK modulation by the Nde1-Lis1-Brap complex patterns mammalian CNS.
p21 Ras/Imp regulate cytokine production and migration in CD4 T cells
Title: p21 Ras/impedes mitogenic signal propagation regulates cytokine production and migration in CD4 T cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables nuclear localization sequence binding	ISO Inferred from Sequence Orthology more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in Ras protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within Ras protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of signal transduction	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of signal transduction	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
part_of ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: BRCA1-associated protein

Names: RING-type E3 ubiquitin transferase BRAP2; impedes mitogenic signal propagation

NP_001276472.1

EC 2.3.2.27

NP_001276473.1

EC 2.3.2.27

NP_082503.2

EC 2.3.2.27

XP_030110689.1

EC 2.3.2.27

XP_036021420.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001289543.1 → NP_001276472.1 BRCA1-associated protein isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an exon in the 5' coding region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.

Source sequence(s)

AC116104, AK143718, BC062932, BY739796

Conserved Domains (3) summary

cd00162
Location:114 → 155

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

cd12718
Location:11 → 94

RRM_BRAP2; RNA recognition motif in BRCA1-associated protein (BRAP2)

pfam02148
Location:168 → 230

zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
NM_001289544.1 → NP_001276473.1 BRCA1-associated protein isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1.

Source sequence(s)

AC116104

Consensus CDS

CCDS80389.1

UniProtKB/Swiss-Prot

Q99MP8

Related

ENSMUSP00000107395.2, ENSMUST00000111765.8

Conserved Domains (3) summary

cd00162
Location:232 → 273

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

cd12718
Location:129 → 212

RRM_BRAP2; RNA recognition motif in BRCA1-associated protein (BRAP2)

pfam02148
Location:286 → 348

zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
NM_028227.3 → NP_082503.2 BRCA1-associated protein isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AC116104, BC062932, BY739796

Consensus CDS

CCDS19640.1

UniProtKB/Swiss-Prot

Q8CC00, Q8CHX1, Q99MP7, Q99MP8, Q9CXX8

Related

ENSMUSP00000031414.9, ENSMUST00000031414.15

Conserved Domains (3) summary

cd00162
Location:262 → 303

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

cd12718
Location:159 → 242

RRM_BRAP2; RNA recognition motif in BRCA1-associated protein (BRAP2)

pfam02148
Location:316 → 378

zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

121798626..121825312

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036165527.1 → XP_036021420.1 BRCA1-associated protein isoform X2

Related

ENSMUST00000127703.3

Conserved Domains (4) summary

COG1196
Location:179 → 372

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd16457
Location:44 → 87

RING-H2_BRAP2; RING finger, H2 subclass, found in BRCA1-associated protein (BRAP2) and similar proteins

pfam02148
Location:99 → 161

zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

cl17169
Location:1 → 25

RRM_SF; RNA recognition motif (RRM) superfamily
XM_030254829.2 → XP_030110689.1 BRCA1-associated protein isoform X1

Conserved Domains (4) summary

COG1196
Location:256 → 449

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd12718
Location:19 → 102

RRM_BRAP2; RNA recognition motif in BRCA1-associated protein (BRAP2)

cd16457
Location:121 → 164

RING-H2_BRAP2; RING finger, H2 subclass, found in BRCA1-associated protein (BRAP2) and similar proteins

pfam02148
Location:176 → 238

zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein